Adhering composition and methods of applying the same

Abstract

A method of in-situ adhering comprising providing pre-gel that comprises a mixture of at least one phenol-based compound and at least one water miscible polymer selected from at least one of a naturally existing form of a carbohydrate, a synthetically prepared form of carbohydrate and a salt of an anionic polysaccharide; spreading a layer of the pre-gel onto a first surface; adding a solid support, comprising at least one cross linking agent capable of interacting with the water miscible polymer to the pre-gel; and allowing the pre-gel to cure and adhere onto the first surface.

What is claimed is: 
     
         1 . A method of in-situ adhering comprising: providing pre-gel that comprises a mixture of at least one phenol-based compound and at least one water miscible polymer selected from at least one of a naturally existing form of a carbohydrate, a synthetically prepared form of carbohydrate and a salt of an anionic polysaccharide; spreading a layer of said pre-gel onto a first surface; adding a solid support, comprising at least one cross linking agent capable of interacting with said at least one water miscible polymer, to said pre-gel; allowing said pre-gel to cure and adhere onto the first surface. 
     
     
         2 . A method of in-situ adhering comprising: providing pre-gel that comprises at least one phenol-based compound, at least one water miscible polymer selected from at least one of a naturally existing form of a carbohydrate, a synthetically prepared form of carbohydrate and a salt of an anionic polysaccharide, and a cross linking agent comprising at least one water-insoluble salt of multivalent ions capable of interacting with said at least one water miscible polymer; spreading a layer of said pre-gel onto a first surface; adding a solid support to said pre-gel; adding to and blending with the pre-gel at least one trigger compound capable of triggering release of multivalent ions from the cross linking agent into the pre-gel, allowing the pre-gel to cure and adhere to the first surface. 
     
     
         3 . The method as claimed in  claim 1 , wherein said curing and adhering is achieved by a method selected from one or more of a group comprising spraying, dripping, and wetting the solid support with said cross linking agent. 
     
     
         4 . The method as claimed in  claim 1 , wherein said at least one cross linking agent is provided within said solid support. 
     
     
         5 . The method as claimed in  claim 1 , further comprising soaking said solid support with said pre-gel. 
     
     
         6 . The method as claimed in  claim 1 , further comprising embedding said solid support within said pre-gel. 
     
     
         7 . The method as claimed in  claim 1 , wherein said solid support is coated with said cross linking agent. 
     
     
         8 . The method as claimed in  claim 1 , further comprising drying said pre-gel. 
     
     
         9 . The method as claimed in  claim 1 , wherein said first surface is a surface selected from a group of tissue surface, graft surface, and organ surface. 
     
     
         10 . The method as claimed in  claim 2 , wherein said first surface is a surface selected from a group of tissue surface, graft surface, and organ surface. 
     
     
         11 . The method of adhering as claimed in  claim 1 , wherein said adhering is under dry or wet conditions. 
     
     
         12 . The method of  claim 11 , further comprising adhering the first surface to a second surface, wherein each of said first surface and said second surface is dry. 
     
     
         13 . The method of  claim 11 , further comprising adhering the first surface to a second surface, wherein at least one of said first surface and said second surface is wet. 
     
     
         14 . The method of  claim 13 , wherein at least one of said first surface and said second surface is a body part or a component thereof, of a human or animal subject. 
     
     
         15 . The method of  claim 14 , wherein said component is a tissue. 
     
     
         16 . The method of  claim 1 , wherein said adhering comprises sealing or closing an opening in the first surface. 
     
     
         17 . The method of  claim 16 , wherein said sealing or closing takes place under dry or wet conditions. 
     
     
         18 . The method of  claim 16 , wherein said surface having said opening is a body part or a component thereof, of a human or animal subject. 
     
     
         19 . The method of  claim 18 , wherein said component is a tissue. 
     
     
         20 . A method of treating an subject comprising: spreading a pre-gel onto a tissue of the subject, the pre-gel comprising a mixture of at least one phenol-based compound and at least one water miscible polymer selected from at least one of a naturally existing form of a carbohydrate, a synthetically prepared form of carbohydrate and a salt of an anionic polysaccharide; adding a solid support, comprising at least one cross linking agent capable of interacting with said at least one water miscible polymer, to said pre-gel; allowing said pre-gel to cure and adhere onto the tissue.