US2014371437A1PendingUtilityA1

Cell surface coating with hyaluronic acid oligomer derivative

Assignee: KODE BIOTECH LTDPriority: Sep 21, 2005Filed: Mar 10, 2014Published: Dec 18, 2014

Est. expirySep 21, 2025(expired)· nominal 20-yr term from priority

Inventors:Nicola Lewell Carter Deborah Adella Blake Nicolai Bovin Stephen Henry Elena Korchagina Eleanor Christine Williams Alexander Borisovich Tuzikov

C12N 5/0604C08B 37/0072A61P 15/00C12N 5/0006C12N 2533/80C07H 17/04

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Abstract

A method of localizing reproduction assisting hyaluronic acid to reproductive cell surfaces by covalently linking it to lipids is disclosed.

Claims

exact text as granted — not AI-modified

1 - 47 . (canceled) 
     
     
         48 . A method of preparing a water soluble glycosaminoglycan-lipid construct comprising the steps of reductive amination of the terminal residue of the glycosaminoglycan prior to condensation with the N-hydroxysuccinimidyl C 5-7 -alkanedioic acid derivative of phosphatidylethanolamine 
     
     
         49 . The method of  claim 48  where the glycosaminoglycan is heparan sulphate or hyaluronic acid. 
     
     
         50 . The method of  claim 49  where the C5-7-alkanedioic acid is adipic acid. 
     
     
         51 . The method of  claim 50  where the phosphatidylethanolamine is 1,2-O-dioleoyl-sn-glycero-3-phosphatidylethanolamine (DOPE) or 1,2-O-distearyl-sn-glycero-3-phosphatidylethanolamine (DSPE).

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