US2014378435A1PendingUtilityA1

Inhibition of Filovirus Entry Into Cells and Uses Thereof

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Assignee: DAVEY ROBERT APriority: Dec 21, 2009Filed: Sep 8, 2014Published: Dec 25, 2014
Est. expiryDec 21, 2029(~3.4 yrs left)· nominal 20-yr term from priority
Inventors:Robert A. DaveyAndrey KolokoltsovMohammad F. Saeed
A61K 31/277A61K 31/713A61K 31/435A61K 31/4745A61K 31/4741A61K 31/366A61K 31/18A61K 31/554A61K 31/5377A61K 33/00A61K 31/145
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Claims

Abstract

The present invention discloses method to treat infections caused by filovirus. Such a method comprises blocking the PI3 kinase pathway or the calcium-associated pathway at the gene or protein level. Also disclosed herein are the compounds useful in the treatment of filoviral infection.

Claims

exact text as granted — not AI-modified
1 . A method of preventing or treating filovirus infection of a cell, comprising:
 contacting the cell with a sole active agent that is a calcium channel blocker, wherein the contacting inhibits the entry of the filovirus into the cell.   
     
     
         2 . The method of  claim 1 , wherein the calcium channel blocker is Tetrandrine. 
     
     
         3 . The method of  claim 1 , wherein the calcium channel blocker is Diltiazem. 
     
     
         4 . The method of  claim 1 , wherein the calcium channel blocker is KN-93. 
     
     
         5 . The method of  claim 1 , wherein the calcium channel blocker is a dihydropyridine. 
     
     
         6 . The method of  claim 1 , wherein the calcium channel blocker is Nimodipine. 
     
     
         7 . The method of  claim 1 , wherein the filovirus is an Ebola virus or a Marburg virus. 
     
     
         8 . A method of treating filovirus infection in an individual infected with a filovirus consisting essentially of:
 administering a pharmacologically effective amount of a calcium channel blocker, thereby treating the individual infected with the filovirus.   
     
     
         9 . The method of  claim 8 , wherein the calcium channel blocker is Tetrandrine. 
     
     
         10 . The method of  claim 8 , wherein the calcium channel blocker is Diltiazem. 
     
     
         11 . The method of  claim 8 , wherein the calcium channel blocker is Nimodipine. 
     
     
         12 . The method of  claim 8 , wherein the calcium channel blocker is KN-93. 
     
     
         13 . The method of  claim 8 , wherein the calcium channel blocker is a dihydropyridine. 
     
     
         14 . The method of  claim 8 , wherein said filovirus is an Ebola virus or a Marburg virus.

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