Compounds and compositions as c-kit kinase inhibitors

Abstract

The invention provides compounds of formulae (I) and (II) and pharmaceutical compositions thereof, which are useful as protein kinase inhibitors, as well as methods for using such compounds to treat, ameliorate or prevent a condition associated with abnormal or deregulated kinase activity. In some embodiments, the invention provides methods for using such compounds to treat, ameliorate or prevent diseases or disorders that involve abnormal activation of c-kit or c-kit and PDGFR (PDGFRα, PDGFRβ) kinases.

1 . A compound of Formula (I) or Formula (II), or a pharmaceutically acceptable salt thereof: 
       
         
           
           
               
               
           
         
         wherein:
 m is 1 and R 20  is selected from H, halo, C 1 -C 6 alkyl, C 1 -C 6 haloalkyl, C 1 -C 6 haloalkoxy, deuterium, deuterated C 1 -C 6 alkyl, —CN, —(CR 9   2 ) n OR 4 , —C(O)R 4 , —(CR 9   2 ) n C(═O)OR 4 , R 8 , —(CR 9   2 ) n R 8 , —((CR 9   2 ) n O) t R 4 , —(CR 9   2 ) n O(CR 9   2 ) n R 6 , —(CR 9   2 ) n C(═O)R 4 , —C(═O)N(R 4 ) 2 , —N(R 4 ) 2 , —C(═S)N(R 4 ) 2 , —(CR 9   2 ) n OR 4 , —OW and —(CR 9   2 ) n CN, 
 or m is 4 and R 20  is deuterium; 
 R 1  is selected from C 1 -C 6 alkyl and halo; 
 each R 11  is independently selected from H, halo and C 1 -C 6 alkyl; 
 L 1  is a bond, —NH— or —C(O)NH—; 
 R 2  is selected from C 1 -C 6 alkyl, C 1 -C 6 haloalkyl, C 2 -C 8 alkenyl, —(CR 9   2 ) n OR 4 , —(CR 9   2 ) n R 6 , —(CR 9   2 ) n S(═O) 2 NR 4   2 , —(CR 9   2 ) n CN, —(CR 9   2 ) n C(═O)R 4 , —(CR 9   2 ) n OC(═O)R 4 , —(CR 9   2 ) n C(═O)OR 4 , —(CR 9   2 ) n C(═O)NR 4   2 , —(CR 9   2 ) n OC(═)ONR 4 (CR 9   2 ) n OR 4 , —(CR 9   2 ) n O(CR 9   2 ) n OR 4 , —(CR 9   2 ) n O(CR 9   2 ) n R 6 , —(CR 9   2 ) n O(CR 9   2 ) n O(CR 9   2 ) n R 6 , —(CR 9   2 ) n OCR 9 R 6 R 6 , —(CR 9   2 ) n CR 9 R 5 R 6 , —(CR 9   2 ) n CR 5 R 6 R 6 , —(CR 9   2 ) n CR 9 R 6 OC(O)(CR 9   2 ) n NR 4   2 , —(CR 9   2 ) n OC(O)(CR 9   2 ) n NR 4   2 , —CR 9 R 5 R 6 , —CR 9 R 9 R 5 , —CR 9 R 6 NR 4   2 , —(CR 9   2 ) n NR 4   2 , —NR 4 (CR 9   2 ) n OR 4 , —NR 4 (CR 9   2 ) n R 6 , —NR 4 (CR 9   2 ) n R 4 , —(CR 9   2 )NR 4 C(═O)R 4 , —(CR 9   2 ) n NR 4 C(═O)OR 4 , —(CR 9   2 )NR 4 C(═O)NR 4   2 , —(CR 9   2 )NR 4 C(═O)R 6 , —(CR 9   2 ) n NR 4 S(═O) 2 R 4 , —(CR 9   2 ) n NR 4 C(═O)(CR 9   2 ) n OR 4 , —(CR 9   2 ) n NR 4 C(═O)(CR 9   2 ) n OR 4 , —CR 5 R 5 NR 4 S(═O) 2 R 4 , —(CR 9   2 ) n NR 5 C(═O)R 6 , —(CR 9   2 ) n NR 4 C(═O)(CR 9   2 ) n R 6 , —(CR 9   2 ) n NR 4 C(═O)O(CR 9   2 ) n R 11 , —(CR 9   2 ) n NR 4 C(═O)(CR 9   2 ) n O(CR 9   2 ) n R 6 , and —(CR 9   2 ) n NR 4 C(═O)O(CR 9   2 ) n R 6 ; 
 each R 4  is independently selected from H and C 1 -C 6 alkyl; 
 each R 5  is independently selected from —NHC(O)OR 4 , —OP(O)(OR 4 ) 2  and —(CR 9   2 ) n OR 4 ; 
 each R 6  is a C 1 -C 6 haloalkyl; 
 each R 9  is independently selected from H and C 1 -C 6 alkyl; 
 R 8  is selected from an unsubstituted phenyl, unsubstituted 5-6 membered heteroaryl with 1-2 heteroatoms independently selected from N, O or S, an unsubstituted 5 membered heteroaryl with 1-4 heteroatoms selected from N, an unsubstituted 4-6 membered heterocycloalkyl with 1-2 heteroatoms independently selected from N, O or S, an unsubstituted C 3 -C 8 cycloalkyl, a substituted 5-6 membered heteroaryl with 1-2 heteroatoms independently selected from N, O or S, a substituted phenyl, a substituted 5 membered heteroaryl with 1-4 heteroatoms selected from N, a substituted 4-6 membered heterocycloalkyl with 1-2 heteroatoms independently selected from N, O or S, a substituted C 3 -C 8 cycloalkyl, a oxazolidin-2-one, pyrrolidinone and a pyrrolidin-2-one,
 wherein the substituted phenyl, the substituted 5-6 membered heteroaryl with 1-2 heteroatoms independently selected from N, O or S, the substituted 5 membered heteroaryl with 1-4 heteroatoms selected from N, substituted C 3 -C 8 cycloalkyl and substituted 4-6 membered heterocycloalkyl of R 8  are substituted with 1-3 substituents independently selected from C 1 -C 6 alkyl, halo, —(C(R 9 ) 2 ) n OR 4 , —C(O)NR 4   2 —NR 4   2 , —R 10 , —(C(R 9 ) 2 ) n R 19 , —(C(R 9 ) 2 ) n C(O)OR 4 , —C(O)OR 4 , —(C(R 9 ) 2 ) n C(O)NR 4   2 , —C(O)NR 4 (C(R 9 ) 2 ) n R 19 , —(C(R 9 ) 2 ) n C(O)NR 4 (C(R 9 ) 2 ) n R 19 , —(C(R 9 ) 2 ) n C(O)NR 4 (C(R 9 ) 2 ) n OR 4 , —C(O)NR 4 (C(R 9 ) 2 ) n OR 4 , —C(O)OR 4 , —C(O)R 4  and —S(O) 2 R 4 ; 
 
 R 10  is selected from an unsubstituted phenyl, unsubstituted 5-6 membered heteroaryl with 1-2 heteroatoms independently selected from N, O or S, an unsubstituted 5 membered heteroaryl with 1-4 heteroatoms selected from N, an unsubstituted 4-6 membered heterocycloalkyl with 1-2 heteroatoms independently selected from N, O or S, an unsubstituted C 3 -C 8 cycloalkyl, a substituted 5-6 membered heteroaryl with 1-2 heteroatoms independently selected from N, O or S, a substituted phenyl, a substituted 5 membered heteroaryl with 1-4 heteroatoms selected from N, a substituted 4-6 membered heterocycloalkyl with 1-2 heteroatoms independently selected from N, O or S, and a substituted C 3 -C 8 cycloalkyl,
 wherein the substituted phenyl, the substituted 5-6 membered heteroaryl with 1-2 heteroatoms independently selected from N, O or S, the substituted 5 membered heteroaryl with 1-4 heteroatoms selected from N, substituted C 3 -C 8 cycloalkyl and substituted 4-6 membered heterocycloalkyl of R 10  are substituted with 1-3 substituents independently selected from C 1 -C 6 alkyl, and —(C(R 9 ) 2 ) n OR 4 ; 
 
 t is 1, 2 or 3, and 
 each n is independently selected from 1, 2, 3 and 4. 
 
       
     
     
         2 . The compound of  claim 1  wherein:
 m is 1 and R 20  is selected from H, halo, C 1 -C 6 alkyl, C 1 -C 6 haloalkyl, C 1 -C 6 haloalkoxy, deuterium, deuterated C 1 -C 6 alkyl, —CN, —(CR 9   2 ) n OR 4 , —C(O)R 4 , —(CR 9   2 ) n C(═O)OR 4 , R 8 , —(CR 9   2 ) n R 8 , —((CR 9   2 ) n O) t R 4 , —(CR 9   2 ) n O(CR 9   2 ) n R 6 , —(CR 9   2 ) n C(═O)R 4 , —C(═O)N(R 4 ) 2 , —(CR 9   2 ) n OR 4 , —OR 4  and —(CR 9   2 ) n CN, 
 or m is 4 and R 20  is deuterium; 
 R 1  is selected from C 1 -C 6 alkyl and halo; 
 each R 11  is independently selected from H, halo and C 1 -C 6 alkyl; 
 L 1  is a bond, —NH— or —C(O)NH—; 
 R 2  is selected from C 1 -C 6 alkyl, C 1 -C 6 haloalkyl, C 2 -C 8 alkenyl, —(CR 9   2 ) n OR 4 , —(CR 9   2 ) n R 6 , —(CR 9   2 ) n S(═O) 2 NR 4   2 , —(CR 9   2 ) n CN, —(CR 9   2 ) n C(═O)R 4 , —(CR 9   2 ) n OC(═O)R 4 , —(CR 9   2 ) n C(═O)OR 4 , —(CR 9   2 ) n C(═O)NR 4   2 , —(CR 9   2 ) n OC(═O)NR 4 (CR 9   2 ) n OR 4 , —(CR 9   2 ) n O(CR 9   2 ) n OR 4 , —(CR 9   2 ) n O(CR 9   2 ) n R 6 , —(CR 9   2 ) n O(CR 9   2 ) n O(CR 9   2 ) n R 6 , —(CR 9   2 ) n OCR 9 R 6 R 6 , —(CR 9   2 ) n CR 9 R 5 R 6 , —(CR 9   2 ) n CR 5 R 6 R 6 , —CR 9 R 5 R 6 , —CR 9 R 9 R 5 , —CR 9 R 6 NR 4   2 , —(CR 9   2 ) n NR 4   2 , —NR 4 (CR 9   2 ) n OR 4 , —NR 4 (CR 9   2 ) n R 6 , —NR 4 (CR 9   2 ) n R 4 , —(CR 9   2 )NR 4 C(═O)R 4 , —(CR 9   2 ) n NR 4 C(═O)OR 4 , —(CR 9   2 )NR 4 C(═O)NR 4   2 , —(CR 9   2 )NR 4 C(═O)R 6 , —(CR 9   2 ) n NR 4 S(═O) 2 R 4 , —(CR 9   2 ) n NR 4 C(═O)O(CR 9   2 ) n OR 4 , —(CR 9   2 ) n NR 4 C(═O)(CR 9   2 ) n OR 4 , —CR 5 R 5 NR 4 S(═O) 2 R 4 , —(CR 9   2 ) n NR 5 C(═O)R 6 , —(CR 9   2 ) n NR 4 C(═O)(CR 9   2 ) n R 6 , —(CR 9   2 ) n NR 4 C(═O)O(CR 9   2 ) n R 11 , —(CR 9   2 ) n NR 4 C(═O)(CR 9   2 ) n O(CR 9   2 ) n R 6 , and —(CR 9   2 ) n NR 4 C(═O)O(CR 9   2 ) n R 6 ; 
 each R 4  is independently selected from H and C 1 -C 6 alkyl; 
 each R 5  is independently selected from —NHC(O)OR 4 , —OR 4  and —(CR 9   2 ) n OR 4 ; 
 each R 6  is a C 1 -C 6 haloalkyl; 
 each R 9  is independently selected from H and C 1 -C 6 alkyl; 
 R 8  is selected from an unsubstituted phenyl, unsubstituted 5-6 membered heteroaryl with 1-2 heteroatoms independently selected from N, O or S, an unsubstituted 5 membered heteroaryl with 1-4 heteroatoms selected from N, an unsubstituted 4-6 membered heterocycloalkyl with 1-2 heteroatoms independently selected from N, O or S, an unsubstituted C 3 -C 8 cycloalkyl, a substituted 5-6 membered heteroaryl with 1-2 heteroatoms independently selected from N, O or S, a substituted phenyl, a substituted 5 membered heteroaryl with 1-4 heteroatoms selected from N, a substituted 4-6 membered heterocycloalkyl with 1-2 heteroatoms independently selected from N, O or S, a substituted C 3 -C 8 cycloalkyl, a oxazolidin-2-one, pyrrolidinone and a pyrrolidin-2-one,
 wherein the substituted phenyl, the substituted 5-6 membered heteroaryl with 1-2 heteroatoms independently selected from N, O or S, the substituted 5 membered heteroaryl with 1-4 heteroatoms selected from N, substituted C 3 -C 8 cycloalkyl and substituted 4-6 membered heterocycloalkyl of R 8  are substituted with 1-3 substituents independently selected from C 1 -C 6 alkyl, halo, —(C(R 9 ) 2 ) n OR 4 , —C(O)NR 4   2 —NR 4   2 , —R 10 , —(C(R 9 ) 2 ) n R 10 , —OR 4 , —(C(R 9 ) 2 ) n C(O)OR 4  and —S(O) 2 R 4 ; 
 
 R 10  is selected from an unsubstituted phenyl, unsubstituted 5-6 membered heteroaryl with 1-2 heteroatoms independently selected from N, O or S, an unsubstituted 5 membered heteroaryl with 1-4 heteroatoms selected from N, an unsubstituted 4-6 membered heterocycloalkyl with 1-2 heteroatoms independently selected from N, O or S, an unsubstituted C 3 -C 8 cycloalkyl, a substituted 5-6 membered heteroaryl with 1-2 heteroatoms independently selected from N, O or S, a substituted phenyl, a substituted 5 membered heteroaryl with 1-4 heteroatoms selected from N, a substituted 4-6 membered heterocycloalkyl with 1-2 heteroatoms independently selected from N, O or S, and a substituted C 3 -C 8 cycloalkyl,
 wherein the substituted phenyl, the substituted 5-6 membered heteroaryl with 1-2 heteroatoms independently selected from N, O or S, the substituted 5 membered heteroaryl with 1-4 heteroatoms selected from N, substituted C 3 -C 8 cycloalkyl and substituted 4-6 membered heterocycloalkyl of R 10  are substituted with 1-3 substituents independently selected from C 1 -C 6 alkyl, and —(C(R 9 ) 2 ) n OR 4 ; 
 
 t is 1, 2 or 3, and 
 each n is independently selected from 1, 2, 3 and 4. 
 
     
     
         3 . The compound of  claim 1 , wherein the compound is a compound of Formula (Ia), Formula (IIa), Formula (Ib) or Formula (IIb): 
       
         
           
           
               
               
           
         
         wherein:
 m is 1 and R 20  is selected from H, halo, C 1 -C 6 alkyl, C 1 -C 6 haloalkyl, C 1 -C 6 haloalkoxy, deuterium, deuterated C 1 -C 6 alkyl, —CN, —(CR 9   2 ) n OR 4 , —C(O)R 4 , —(CR 9   2 ) n C(═O)OR 4 , R 8 , —(CR 9   2 ) n R 8 , —((CR 9   2 ) n O) t R 4 , —(CR 9   2 ) n O(CR 9   2 ) n R 6 , —(CR 9   2 ) n C(═O)R 4 , —C(═O)N(R 4 ) 2 , —(CR 9   2 ) n OR 4 , —OR 4  and —(CR 9   2 ) n CN; 
 or m is 4 and R 20  is deuterium; 
 R 1  is selected from C 1 -C 6 alkyl and halo; 
 each R 11  is independently selected from H, halo and C 1 -C 6 alkyl; 
 R 2  is selected from C 1 -C 6 alkyl, C 1 -C 6 haloalkyl, C 2 -C 8 alkenyl, —(CR 9   2 ) n OR 4 , —(CR 9   2 ) n R 6 , —(CR 9   2 ) n S(═O) 2 NR 4   2 , —(CR 9   2 ) n CN, —(CR 9   2 ) n C(═O)R 4 , —(CR 9   2 ) n OC(═O)R 4 , —(CR 9   2 ) n C(═O)OR 4 , —(CR 9   2 ) n C(═O)NR 4   2 , —(CR 9   2 ) n OC(═)ONR 4 (CR 9   2 ) n OR 4 , —(CR 9   2 ) n O(CR 9   2 ) n OR 4 , —(CR 9   2 ) n O(CR 9   2 ) n R 6 , —(CR 9   2 ) n O(CR 9   2 ) n O(CR 9   2 ) n R 6 , —(CR 9   2 ) n OCR 9 R 6 R 6 , —(CR 9   2 ) n CR 9 R 5 R 6 , —(CR 9   2 ) n CR 5 R 6 R 6 , —CR 9 R 5 R 6 , —CR 9 R 9 R 5 , —CR 9 R 6 NR 4   2 , —(CR 9   2 ) n NR 4   2 , —NR 4 (CR 9   2 ) n OR 4 , —NR 4 (CR 9   2 ) n R 6 , —NR 4 (CR 9   2 ) n R 4 , —(CR 9   2 )NR 4 C(═O)R 4 , —(CR 9   2 ) n NR 4 C(═O)OR 4 , —(CR 9   2 )NR 4 C(═O)NR 4   2 , —(CR 9   2 )NR 4 C(═O)R 6 , —(CR 9   2 ) n NR 4 S(═O) 2 R 4 , —(CR 9   2 ) n NR 4 C(═O)O(CR 9   2 ) n OR 4 , —(CR 9   2 ) n NR 4 C(═O)(CR 9   2 ) n OR 4 , —CR 5 R 5 NR 4 S(═O) 2 R 4 , —(CR 9   2 ) n NR 5 C(═O)R 6 , —(CR 9   2 ) n NR 4 C(═O)(CR 9   2 ) n R 6 , —(CR 9   2 ) n NR 4 C(═O)O(CR 9   2 ) n R 11 , —(CR 9   2 ) n NR 4 C(═O)(CR 9   2 ) n O(CR 9   2 ) n R 6 , and —(CR 9   2 ) n NR 4 C(═O)O(CR 9   2 ) n R 6 ; 
 each R 4  is independently selected from H and C 1 -C 6 alkyl; 
 each R 5  is independently selected from —NHC(O)OR 4 , —OR 4  and —(CR 9   2 ) n OR 4 ; 
 each R 6  is a C 1 -C 6 haloalkyl; 
 each R 9  is independently selected from H and C 1 -C 6 alkyl; 
 R 8  is selected from an unsubstituted phenyl, unsubstituted 5-6 membered heteroaryl with 1-2 heteroatoms independently selected from N, O or S, an unsubstituted 5 membered heteroaryl with 1-4 heteroatoms selected from N, an unsubstituted 4-6 membered heterocycloalkyl with 1-2 heteroatoms independently selected from N, O or S, an unsubstituted C 3 -C 8 cycloalkyl, a substituted 5-6 membered heteroaryl with 1-2 heteroatoms independently selected from N, O or S, a substituted phenyl, a substituted 5 membered heteroaryl with 1-4 heteroatoms selected from N, a substituted 4-6 membered heterocycloalkyl with 1-2 heteroatoms independently selected from N, O or S, a substituted C 3 -C 8 cycloalkyl, a oxazolidin-2-one, pyrrolidinone and a pyrrolidin-2-one,
 wherein the substituted phenyl, the substituted 5-6 membered heteroaryl with 1-2 heteroatoms independently selected from N, O or S, the substituted 5 membered heteroaryl with 1-4 heteroatoms selected from N, substituted C 3 -C 8 cycloalkyl and substituted 4-6 membered heterocycloalkyl of R 8  are substituted with 1-3 substituents independently selected from C 1 -C 6 alkyl, halo, —(C(R 9 ) 2 ) n OR 4 , —C(O)NR 4   2 —NR 4   2 , —R 10 , —(C(R 9 ) 2 ) n R 10 , —(C(R 9 ) 2 ) n C(O)OR 4  and —S(O) 2 R 4 ; 
 
 R 10  is selected from an unsubstituted phenyl, unsubstituted 5-6 membered heteroaryl with 1-2 heteroatoms independently selected from N, O or S, an unsubstituted 5 membered heteroaryl with 1-4 heteroatoms selected from N, an unsubstituted 4-6 membered heterocycloalkyl with 1-2 heteroatoms independently selected from N, O or S, an unsubstituted C 3 -C 8 cycloalkyl, a substituted 5-6 membered heteroaryl with 1-2 heteroatoms independently selected from N, O or S, a substituted phenyl, a substituted 5 membered heteroaryl with 1-4 heteroatoms selected from N, a substituted 4-6 membered heterocycloalkyl with 1-2 heteroatoms independently selected from N, O or S, and a substituted C 3 -C 8 cycloalkyl,
 wherein the substituted phenyl, the substituted 5-6 membered heteroaryl with 1-2 heteroatoms independently selected from N, O or S, the substituted 5 membered heteroaryl with 1-4 heteroatoms selected from N, substituted C 3 -C 8 cycloalkyl and substituted 4-6 membered heterocycloalkyl of R 10  are substituted with 1-3 substituents independently selected from C 1 -C 6 alkyl, and —(C(R 9 ) 2 ) n OR 4 ; 
 
 t is 1, 2 or 3, and 
 each n is independently selected from 1, 2, 3 and 4. 
 
       
     
     
         4 . The compound of  claim 1  wherein R 1  is selected from —CH 3  and F. 
     
     
         5 . The compound of  claim 1 , wherein R 1  is —CH 3 . 
     
     
         6 . The compound of  claim 1 , wherein each R 11  is independently selected from H, F and —CH 3 . 
     
     
         7 . The compound of  claim 1 , wherein each R 11  is H. 
     
     
         8 . The compound of  claim 1 , wherein:
 R 2  is selected from —(CR 9   2 ) n CN, —(CR 9   2 ) n NR 4 C(═O)OR 4 , —(CR 9   2 ) n OR 4 , —(CR 9   2 ) n C(═O)NR 4   2 , —(CR 9   2 ) n C(═O)R 4 , C 1 -C 6 alkyl, C 2 -C 8 alkenyl, —(CR 9   2 ) n CR 5 R 6 R 6 , —CR 5 R 5 NR 4 S(═O) 2 R 4 , —(CR 9   2 ) n NR 4 S(═O) 2 R 4 , —(CR 9   2 )NR 4 C(═O)R 6 , —(CR 9   2 ) n O(CR 9   2 ) n OR 4 , —(CR 9   2 ) n C(═O)OR 4 , —(CR 9   2 ) n O(CR 9   2 ) n R 6 , —(CR 9   2 ) n CR 9 R 5 R 6 , —NR 4 (CR 9   2 ) n R 6 , —NR 4 (CR 9   2 ) n R 4 , —(CR 9   2 ) n R 6  and —(CR 9   2 ) n OCR 9 R 6 R 6 .   
     
     
         9 . The compound of  claim 1 , wherein:
 R 2  is selected from —(CR 9   2 ) n CR 9 R 5 R 6  and —(CR 9   2 ) n OR 4 .   
     
     
         10 . The compound of  claim 1 , wherein each R 4  is independently selected from H, methyl, ethyl, propyl, butyl, i-propyl and t-butyl. 
     
     
         11 . The compound of  claim 1 , wherein each R 5  is independently selected from, —OR 4  and —(CR 9   2 ) n OR 4 . 
     
     
         12 . The compound of  claim 1 , wherein each R 5  is independently selected from OH and —CH 2 OH. 
     
     
         13 . The compound of  claim 1 , wherein each R 6  is independently selected from —CH 2 F, —CHF 2 , —CH 2 CHF 2 , —CH 2 CF 3  and —CF 3 . 
     
     
         14 . The compound of  claim 1 , wherein each R 9  is independently selected from H, methyl and ethyl. 
     
     
         15 . (canceled) 
     
     
         16 . The compound of  claim 1 , wherein R 2  is —C(CH 3 ) 2 CH 2 OH or —CH 2 CH 2 C(CH 3 )OHCF 3 . 
     
     
         17 . The compound of  claim 1  wherein m is 1 and R 20  is selected from H, halo, C 1 -C 6 alkyl, C 1 -C 6 haloalkyl, deuterated C 1 -C 6 alkyl, —CN, —(CR 9   2 ) n OR 4 , —R 8 , —(CR 9   2 ) n R 8 , —(CR 9   2 ) n O(CR 9   2 ) n R 6 , —(CR 9   2 ) n C(═O)R 4 , —(CR 9   2 ) n OR 4  and —OR 4 . 
     
     
         18 . The compound of  claim 1 , wherein m is 1 and R 20  is selected from H, —F, —CH 3 , —CF 3 , —CD 3 , —CN, —OCHF 2 , —CH 2 CH 2 C(CH 3 ) 2 OH, —CH 2 OCH 2 CF 3 , —CH 2 CH 2 C(═O)CH 3 , —CH 2 OCH 3  and —OCH 3 . 
     
     
         19 . The compound of  claim 1 , wherein m is 1 and R 20  is H or —CH 3 . 
     
     
         20 . (canceled) 
     
     
         21 . (canceled) 
     
     
         22 . The compound of  claim 1 , wherein:
 R 8  is selected from phenyl, morpholinyl, cyclopropyl, pyridinyl, pyridine-3-yl, pyridine-4-yl, pyrazolyl, pyrazol-1-yl, pyrazol-3-yl, pyrazol-4-yl, pyrrolyl, triazolyl, 1H-1,2,3-triazol-4-yl, 4H-1,2,4-triazol-3-yl, 1H-1,2,4-triazol-5-yl, thiazolyl, thiazol-4-yl, thiazol-5-yl, isoxazolyl and isoxazol-4-yl, each of which is unsubstituted or each of which is substituted with 1-3 substituents independently selected from F, —CH 3 , —C(CH 3 ) 2 CH 2 OH, —CH 2 OCH 3 , —C(O)NHCH 3 , —NH 2  and —OCH 3 .   
     
     
         23 . (canceled) 
     
     
         24 . The compound of  claim 1  selected from:
 N-{5-[5-(2-cyanoethyl)-1,2,4-oxadiazol-3-yl]-2-methylphenyl}imidazo[1,2-a]pyridine-3-carboxamide; 
 tert-butyl N-{2-[3-(3-{imidazo[1,2-a]pyridine-3-amido}-4-methylphenyl)-1,2,4-oxadiazol-5-yl]ethyl}carbamate; 
 N-{5-[5-(3-methoxypropyl)-1,2,4-oxadiazol-3-yl]-2-methylphenyl}imidazo[1,2-a]pyridine-3-carboxamide; 
 N-(5-{5-[2-(diethylcarbamoyl)ethyl]-1,2,4-oxadiazol-3-yl}-2-methylphenyl)imidazo[1,2-a]pyridine-3-carboxamide; 
 N-{2-methyl-5-[5-(3-oxobutyl)-1,2,4-oxadiazol-3-yl]phenyl}imidazo[1,2-a]pyridine-3-carboxamide; 
 tert-butyl N-{[3-(3-{imidazo[1,2-a]pyridine-3-amido}-4-methylphenyl)-1,2,4-oxadiazol-5-yl]methyl}carbamate; 
 ethyl 2-[3-(3-{imidazo[1,2-a]pyridine-3-amido}-4-methylphenyl)-1,2,4-oxadiazol-5-yl]acetate; 
 N-{5-[5-(3-hydroxy-3-methylbutyl)-1,2,4-oxadiazol-3-yl]-2-methylphenyl}imidazo[1,2-a]pyridine-3-carboxamide; 
 N-{5-[5-(3-hydroxybutyl)-1,2,4-oxadiazol-3-yl]-2-methylphenyl}imidazo[1,2-a]pyridine-3-carboxamide; 
 N-{5-[5-(2-ethoxyethyl)-1,2,4-oxadiazol-3-yl]-2-methylphenyl}imidazo[1,2-a]pyridine-3-carboxamide; 
 N-[2-methyl-5-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl]imidazo[1,2-a]pyridine-3-carboxamide; 
 N-{5-[5-(ethoxymethyl)-1,2,4-oxadiazol-3-yl]-2-methylphenyl}imidazo[1,2-a]pyridine-3-carboxamide; 
 tert-butyl N-[(1S)-1-[3-(3-{imidazo[1,2-a]pyridine-3-amido}-4-methylphenyl)-1,2,4-oxadiazol-5-yl]ethyl]carbamate; 
 N-(5-{5-[(1R)-1-methoxyethyl]-1,2,4-oxadiazol-3-yl}-2-methylphenyl)imidazo[1,2-a]pyridine-3-carboxamide; 
 N-{2-methyl-5-[5-(3,3,3-trifluoro-2-hydroxy-2-methylpropyl)-1,2,4-oxadiazol-3-yl]phenyl}imidazo[1,2-a]pyridine-3-carboxamide; 
 N-(2-methyl-5-{5-[3,3,3-trifluoro-2-hydroxy-2-(trifluoromethyl)propyl]-1,2,4-oxadiazol-3-yl}phenyl)imidazo[1,2-a]pyridine-3-carboxamide; 
 N-{5-[5-(1,3-dihydroxy-2-methanesulfonamidopropan-2-yl)-1,2,4-oxadiazol-3-yl]-2-methylphenyl}imidazo[1,2-a]pyridine-3-carboxamide; 
 N-(5-{5-[(1R)-1-methanesulfonamidoethyl]-1,2,4-oxadiazol-3-yl}-2-methylphenyl)imidazo[1,2-a]pyridine-3-carboxamide; 
 tert-butyl N-{[3-(3-{imidazo[1,2-a]pyridine-3-amido}-4-methylphenyl)-1,2,4-oxadiazol-5-yl]methyl}-N-methylcarbamate; 
 N-{5-[5-(ethanesulfonamidomethyl)-1,2,4-oxadiazol-3-yl]-2-methylphenyl}imidazo[1,2-a]pyridine-3-carboxamide; 
 tert-butyl N-ethyl-N-{[3-(3-{imidazo[1,2-a]pyridine-3-amido}-4-methylphenyl)-1,2,4-oxadiazol-5-yl]methyl}carbamate; 
 N-(5-{5-[(N-ethylmethanesulfonamido)methyl]-1,2,4-oxadiazol-3-yl}-2-methylphenyl)imidazo[1,2-a]pyridine-3-carboxamide; 
 methyl N-ethyl-N-{[3-(3-{imidazo[1,2-a]pyridine-3-amido}-4-methylphenyl)-1,2,4-oxadiazol-5-yl]methyl}carbamate; 
 N-(2-methyl-5-{5-[(2,2,2-trifluoroacetamido)methyl]-1,2,4-oxadiazol-3-yl}phenyl)imidazo[1,2-a]pyridine-3-carboxamide; 
 N-{2-methyl-5-[5-(propane-2-sulfonamidomethyl)-1,2,4-oxadiazol-3-yl]phenyl}imidazo[1,2-a]pyridine-3-carboxamide; 
 N-(5-{5-[(2-methoxyethoxy)methyl]-1,2,4-oxadiazol-3-yl}-2-methylphenyl)imidazo[1,2-a]pyridine-3-carboxamide; 
 tert-butyl 2-[3-(3-{imidazo[1,2-a]pyridine-3-amido}-4-methylphenyl)-1,2,4-oxadiazol-5-yl]acetate; 
 N-(2-methyl-5-{5-[2-(2,2,2-trifluoroethoxy)ethyl]-1,2,4-oxadiazol-3-yl}phenyl)imidazo[1,2-a]pyridine-3-carboxamide; 
 ethyl N-{[3-(3-{imidazo[1,2-a]pyridine-3-amido}-4-methylphenyl)-1,2,4-oxadiazol-5-yl]methyl}carbamate; 
 propan-2-yl N-{[3-(3-{imidazo[1,2-a]pyridine-3-amido}-4-methylphenyl)-1,2,4-oxadiazol-5-yl]methyl}carbamate; 
 N-(2-methyl-5-{5-[(2R)-3,3,3-trifluoro-2-hydroxypropyl]-1,2,4-oxadiazol-3-yl}phenyl)imidazo[1,2-a]pyridine-3-carboxamide; 
 N-(5-{5-[(2-ethoxyethoxy)methyl]-1,2,4-oxadiazol-3-yl}-2-methylphenyl)imidazo[1,2-a]pyridine-3-carboxamide; 
 N-[2-methyl-5-(5-{[2-(propan-2-yloxy)ethoxy]methyl}-1,2,4-oxadiazol-3-yl)phenyl]imidazo[1,2-a]pyridine-3-carboxamide; 
 N-[5-(5-{[2-(tert-butoxy)ethoxy]methyl}-1,2,4-oxadiazol-3-yl)-2-methylphenyl]imidazo[1,2-a]pyridine-3-carboxamide; 
 N-(2-methyl-5-{5-[(3,3,3-trifluoropropanamido)methyl]-1,2,4-oxadiazol-3-yl}phenyl)imidazo[1,2-a]pyridine-3-carboxamide; 
 6-fluoro-N-{5-[5-(3-hydroxy-3-methylbutyl)-1,2,4-oxadiazol-3-yl]-2-methylphenyl}imidazo[1,2-a]pyridine-3-carboxamide; 
 6-fluoro-N-(5-{5-[(2-methoxyethoxy)methyl]-1,2,4-oxadiazol-3-yl}-2-methylphenyl)imidazo[1,2-a]pyridine-3-carboxamide; 
 ethyl N-{[3-(3-{6-fluoroimidazo[1,2-a]pyridine-3-amido}-4-methylphenyl)-1,2,4-oxadiazol-5-yl]methyl}carbamate; 
 N-(2-methyl-5-{5-[(2,2,2-trifluoroethoxy)methyl]-1,2,4-oxadiazol-3-yl}phenyl)imidazo[1,2-a]pyridine-3-carboxamide; 
 2,2-difluoroethyl N-{[3-(3-{imidazo[1,2-a]pyridine-3-amido}-4-methylphenyl)-1,2,4-oxadiazol-5-yl]methyl}carbamate; 
 methyl N-({3-[4-methyl-3-(7-{1-[2-(morpholin-4-yl)ethyl]-1H-pyrazol-4-yl}imidazo[1,2-a]pyridine-3-amido)phenyl]-1,2,4-oxadiazol-5-yl}methyl)carbamate; 
 N-{5-[5-(3-hydroxy-3-methylbutyl)-1,2,4-oxadiazol-3-yl]-2-methylphenyl}-7-(1-methyl-1H-pyrazol-3-yl)imidazo[1,2-a]pyridine-3-carboxamide; 
 N-[2-methyl-5-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl]-6-(1H-pyrazol-4-yl)imidazo[1,2-a]pyridine-3-carboxamide; 
 6-(1-methyl-1H-pyrazol-4-yl)-N-[2-methyl-5-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl]imidazo[1,2-a]pyridine-3-carboxamide; 
 6-[1-(2-hydroxy-2-methylpropyl)-1H-pyrazol-4-yl]-N-[2-methyl-5-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl]imidazo[1,2-a]pyridine-3-carboxamide; 
 N-(5-{[5-(1-hydroxy-2-methylpropan-2-yl)-1,2,4-oxadiazol-3-yl]amino}-2-methylphenyl)imidazo[1,2-a]pyridine-3-carboxamide; 
 N-[2-methyl-5-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl]-6-(1,3-thiazol-4-yl)imidazo[1,2-a]pyridine-3-carboxamide; 
 6-(2,4-dimethyl-1,3-thiazol-5-yl)-N-[2-methyl-5-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl]imidazo[1,2-a]pyridine-3-carboxamide; 
 6-(3,5-dimethyl-1,2-oxazol-4-yl)-N-[2-methyl-5-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl]imidazo[1,2-a]pyridine-3-carboxamide; 
 N-{5-[5-(3-hydroxy-3-methylbutyl)-1,2,4-oxadiazol-3-yl]-2-methylphenyl}-7-methylimidazo[1,2-a]pyridine-3-carboxamide; 
 N-[2-methyl-5-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl]-6-{1-[2-(morpholin-4-yl)ethyl]-1H-pyrazol-4-yl}imidazo[1,2-a]pyridine-3-carboxamide; 
 5,6,7,8-tetradeutero-N-{2-methyl-5-[5-(3-methylbut-2-en-1-yl)-1,2,4-oxadiazol-3-yl]phenyl}imidazo[1,2-a]pyridine-3-carboxamide; 
 5,6,7,8-tetradeutero-N-(5-{5-[(2-methoxyethoxy)methyl]-1,2,4-oxadiazol-3-yl}-2-methylphenyl)imidazo[1,2-a]pyridine-3-carboxamide; 
 5,6,7,8-tetradeutero-N-{5-[5-(3-hydroxy-3-methylbutyl)-1,2,4-oxadiazol-3-yl]-2-methylphenyl}imidazo[1,2-a]pyridine-3-carboxamide; 
 propan-2-yl 3-[3-(3-{imidazo[1,2-a]pyridine-3-amido}-4-methylphenyl)-1,2,4-oxadiazol-5-yl]propanoate; 
 N-{5-[5-(3-hydroxy-3-methylbutyl)-1,2,4-oxadiazol-3-yl]-2-methylphenyl}-6-methoxyimidazo[1,2-a]pyridine-3-carboxamide; 
 N-{5-[5-(3-hydroxy-3-methylbutyl)-1,2,4-oxadiazol-3-yl}-2-methylphenyl]-6-methylimidazo[1,2-a]pyridine-3-carboxamide; 
 N-(5-{5-[(2-methoxyethoxy)methyl]-1,2,4-oxadiazol-3-yl}-2-methylphenyl)-6-methylimidazo[1,2-a]pyridine-3-carboxamide; 
 N-{2-methyl-5-[5-(pentan-2-yl)-1,2,4-oxadiazol-3-yl]phenyl}imidazo[1,2-a]pyridine-3-carboxamide; 
 N-{5-[5-(3-hydroxy-3-methylbutyl)-1,2,4-oxadiazol-3-yl]-2-methylphenyl}-7-(morpholin-4-yl)imidazo[1,2-a]pyridine-3-carboxamide; 
 N-{5-[5-(3-hydroxy-3-methylbutyl)-1,2,4-oxadiazol-3-yl]-2-methylphenyl}-7-(2-oxo-1,3-oxazolidin-3-yl)imidazo[1,2-a]pyridine-3-carboxamide; 
 N-{5-[5-(3-hydroxy-3-methylbutyl)-1,2,4-oxadiazol-3-yl]-2-methylphenyl}-7-(2-oxopyrrolidin-1-yl)imidazo[1,2-a]pyridine-3-carboxamide; 
 N-{5-[5-(3-hydroxy-3-methylbutyl)-1,2,4-oxadiazol-3-yl]-2-methylphenyl}-7-(1-methyl-1H-pyrazol-4-yl)imidazo[1,2-a]pyridine-3-carboxamide; 
 7-cyclopropyl-N-{5-[5-(3-hydroxy-3-methylbutyl)-1,2,4-oxadiazol-3-yl]-2-methylphenyl}imidazo[1,2-a]pyridine-3-carboxamide; 
 7-fluoro-N-(5-{5-[(2-hydroxy-2-methylpropyl)(methyl)amino]-1,2,4-oxadiazol-3-yl}-2-methylphenyl)imidazo[1,2-a]pyridine-3-carboxamide; 
 N-{2-methyl-5-[5-(4,4,4-trifluoro-3-hydroxy-3-methylbutyl)-1,2,4-oxadiazol-3-yl]phenyl}imidazo[1,2-a]pyridine-3-carboxamide; 
 7-methyl-N-{2-methyl-5-[5-(4,4,4-trifluoro-3-hydroxy-3-methylbutyl)-1,2,4-oxadiazol-3-yl]phenyl}imidazo[1,2-a]pyridine-3-carboxamide; 
 N-(5-{5-[(2-fluoroethyl)amino]-1,2,4-oxadiazol-3-yl}-2-methylphenyl)-7-methylimidazo[1,2-a]pyridine-3-carboxamide; 
 7-methyl-N-(2-methyl-5-{5-[(2-methylpropyl)amino]-1,2,4-oxadiazol-3-yl}phenyl)imidazo[1,2-a]pyridine-3-carboxamide; 
 7-fluoro-N-{2-methyl-5-[5-(4,4,4-trifluoro-3-hydroxy-3-methylbutyl)-1,2,4-oxadiazol-3-yl]phenyl}imidazo[1,2-a]pyridine-3-carboxamide; 
 6-fluoro-N-{2-methyl-5-[5-(4,4,4-trifluoro-3-hydroxy-3-methylbutyl)-1,2,4-oxadiazol-3-yl]phenyl}imidazo[1,2-a]pyridine-3-carboxamide; 
 6-methyl-N-{2-methyl-5-[5-(4,4,4-trifluoro-3-hydroxy-3-methylbutyl)-1,2,4-oxadiazol-3-yl]phenyl}imidazo[1,2-a]pyridine-3-carboxamide; 
 5,6,7,8-tetradeutero-N-{2-methyl-5-[5-(4,4,4-trifluoro-3-hydroxy-3-methylbutyl)-1,2,4-oxadiazol-3-yl]phenyl}imidazo[1,2-a]pyridine-3-carboxamide; 
 N-{2-methyl-5-[5-(3,3,3-trifluoropropyl)-1,2,4-oxadiazol-3-yl]phenyl}imidazo[1,2-a]pyridine-3-carboxamide; 
 7-methyl-N-(2-methyl-5-{5-[(3S)-4,4,4-trifluoro-3-hydroxy-3-methylbutyl]-1,2,4-oxadiazol-3-yl}phenyl)imidazo[1,2-a]pyridine-3-carboxamide; 
 7-methyl-N-(2-methyl-5-{5-[(3R)-4,4,4-trifluoro-3-hydroxy-3-methylbutyl]-1,2,4-oxadiazol-3-yl}phenyl)imidazo[1,2-a]pyridine-3-carboxamide; 
 7-methyl-N-(2-methyl-5-{5-[(2,2,2-trifluoroethoxy)methyl]-1,2,4-oxadiazol-3-yl}phenyl)imidazo[1,2-a]pyridine-3-carboxamide; 
 7-methyl-N-(2-methyl-5-{5-[(2,2,2-trifluoroethoxy)methyl]-1,2,4-oxadiazol-3-yl}phenyl)imidazo[1,2-a]pyridine-3-carboxamide; 
 6-methyl-N-(2-methyl-5-{5-[(2,2,2-trifluoroethoxy)methyl]-1,2,4-oxadiazol-3-yl}phenyl)imidazo[1,2-a]pyridine-3-carboxamide; 
 N-{2-methyl-5-[5-(4,4,4-trifluorobutyl)-1,2,4-oxadiazol-3-yl]phenyl}imidazo[1,2-a]pyridine-3-carboxamide; 
 N-[2-methyl-5-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl]-6-(2-methylphenyl)imidazo[1,2-a]pyridine-3-carboxamide; 
 N-[2-methyl-5-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl]-6-(2-methylpyridin-3-yl)imidazo[1,2-a]pyridine-3-carboxamide; 
 N-[2-methyl-5-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl]-6-(3-methylpyridin-4-yl)imidazo[1,2-a]pyridine-3-carboxamide; 
 6-methyl-N-(2-methyl-5-{5-[(3S)-4,4,4-trifluoro-3-hydroxy-3-methylbutyl]-1,2,4-oxadiazol-3-yl}phenyl)imidazo[1,2-a]pyridine-3-carboxamide; 
 6-fluoro-N-(2-methyl-5-{5-[(3S)-4,4,4-trifluoro-3-hydroxy-3-methylbutyl]-1,2,4-oxadiazol-3-yl}phenyl)imidazo[1,2-a]pyridine-3-carboxamide; 
 7-fluoro-N-(2-methyl-5-{5-[(3S)-4,4,4-trifluoro-3-hydroxy-3-methylbutyl]-1,2,4-oxadiazol-3-yl}phenyl)imidazo[1,2-a]pyridine-3-carboxamide; 
 6-methyl-N-(2-methyl-5-{5-[(3R)-4,4,4-trifluoro-3-hydroxy-3-methylbutyl]-1,2,4-oxadiazol-3-yl}phenyl)imidazo[1,2-a]pyridine-3-carboxamide; 
 6-fluoro-N-(2-methyl-5-{5-[(3R)-4,4,4-trifluoro-3-hydroxy-3-methylbutyl]-1,2,4-oxadiazol-3-yl}phenyl)imidazo[1,2-a]pyridine-3-carboxamide; 
 7-fluoro-N-(2-methyl-5-{5-[(3R)-4,4,4-trifluoro-3-hydroxy-3-methylbutyl]-1,2,4-oxadiazol-3-yl}phenyl)imidazo[1,2-a]pyridine-3-carboxamide; 
 7-methyl-N-{2-methyl-5-[5-(4,4,4-trifluoro-3-methoxy-3-methylbutyl)-1,2,4-oxadiazol-3-yl]phenyl}imidazo[1,2-a]pyridine-3-carboxamide; 
 6-(2,4-dimethyl-1,3-thiazol-5-yl)-N-(2-methyl-5-{5-[(2,2,2-trifluoroethoxy)methyl]-1,2,4-oxadiazol-3-yl}phenyl)imidazo[1,2-a]pyridine-3-carboxamide; 
 6-(2-fluoropyridin-3-yl)-N-[2-methyl-5-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl]imidazo[1,2-a]pyridine-3-carboxamide; 
 N-methyl-5-(3-{[2-methyl-5-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl]carbamoyl}imidazo[1,2-a]pyridin-6-yl)pyridine-2-carboxamide; 
 N-(5-{5-[(2,2-difluoroethoxy)methyl]-1,2,4-oxadiazol-3-yl}-2-methylphenyl)imidazo[1,2-a]pyridine-3-carboxamide; 
 N-{5-(5-{[(1,3-difluoropropan-2-yl)oxy]methyl}-1,2,4-oxadiazol-3-yl)-2-methylphenyl}imidazo[1,2-a]pyridine-3-carboxamide; 
 N-[2-methyl-5-(5-{[(1,1,1-trifluoropropan-2-yl)oxy]methyl}-1,2,4-oxadiazol-3-yl)phenyl]imidazo[1,2-a]pyridine-3-carboxamide; 
 6-(4-methyl-1,3-thiazol-5-yl)-N-[2-methyl-5-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl]imidazo[1,2-a]pyridine-3-carboxamide; 
 7-methyl-N-{2-methyl-5-[5-(4,4,4-trifluoro-3-hydroxybutyl)-1,2,4-oxadiazol-3-yl]phenyl}imidazo[1,2-a]pyridine-3-carboxamide; 
 7-methyl-N-(2-methyl-5-{5-[(2R)-3,3,3-trifluoro-2-hydroxypropyl]-1,2,4-oxadiazol-3-yl}phenyl)imidazo[1,2-a]pyridine-3-carboxamide; 
 N-[2-methyl-5-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl]-6-(1,3,5-trimethyl-1H-pyrazol-4-yl)imidazo[1,2-a]pyridine-3-carboxamide; 
 6-(1-methyl-1H-pyrrol-2-yl)-N-[2-methyl-5-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl]imidazo[1,2-a]pyridine-3-carboxamide; 
 6-(4-methoxypyridin-3-yl)-N-[2-methyl-5-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl]imidazo[1,2-a]pyridine-3-carboxamide; 
 6-(2-aminopyridin-4-yl)-N-[2-methyl-5-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl]imidazo[1,2-a]pyridine-3-carboxamide; 
 tert-butyl 2-[3,5-dimethyl-4-(3-{[2-methyl-5-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl]carbamoyl}imidazo[1,2-a]pyridin-6-yl)-1H-pyrazol-1-yl]acetate; 
 6-[5-(1-hydroxyethyl)-4-methyl-1,3-thiazol-2-yl]-N-[2-methyl-5-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl]imidazo[1,2-a]pyridine-3-carboxamide; 
 6-(4,5-dimethyl-1,3-thiazol-2-yl)-N-[2-methyl-5-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl]imidazo[1,2-a]pyridine-3-carboxamide; 
 6-(1-{[(2-hydroxyethyl)carbamoyl]methyl}-3,5-dimethyl-1H-pyrazol-4-yl)-N-[2-methyl-5-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl]imidazo[1,2-a]pyridine-3-carboxamide; 
 6-[3,5-dimethyl-1-({[2-(morpholin-4-yl)ethyl]carbamoyl}methyl)-1H-pyrazol-4-yl]-N-[2-methyl-5-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl]imidazo[1,2-a]pyridine-3-carboxamide; 
 6-carbamothioyl-N-[2-methyl-5-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl]imidazo[1,2-a]pyridine-3-carboxamide; 
 N-(2-hydroxyethyl)-4-methyl-2-(3-{[2-methyl-5-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl]carbamoyl}imidazo[1,2-a]pyridin-6-yl)-1,3-thiazole-5-carboxamide; 
 4-methyl-2-(3-{[2-methyl-5-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl]carbamoyl}imidazo[1,2-a]pyridin-6-yl)-N-[2-(4-methylpiperazin-1-yl)ethyl]-1,3-thiazole-5-carboxamide; 
 4-methyl-2-(3-{[2-methyl-5-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl]carbamoyl}imidazo[1,2-a]pyridin-6-yl)-N-[3-(4-methylpiperazin-1-yl)propyl]-1,3-thiazole-5-carboxamide; 
 4-methyl-2-(3-{[2-methyl-5-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl]carbamoyl}imidazo[1,2-a]pyridin-6-yl)-N-[2-(morpholin-4-yl)ethyl]-1,3-thiazole-5-carboxamide; 
 8-amino-N-{5-[5-(3-hydroxy-3-methylbutyl)-1,2,4-oxadiazol-3-yl]-2-methylphenyl}imidazo[1,2-a]pyridine-3-carboxamide; 
 4-methyl-5-(3-{[2-methyl-5-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl]carbamoyl}imidazo[1,2-a]pyridin-6-yl)-1,3-thiazole-2-carboxylic acid; 
 4-methyl-5-(3-{[2-methyl-5-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl]carbamoyl}imidazo[1,2-a]pyridin-6-yl)-N-[2-(4-methylpiperazin-1-yl)ethyl]-1,3-thiazole-2-carboxamide; 
 2-methyl-4-[3-(4-methyl-3-{7-methylimidazo[1,2-a]pyridine-3-amido}phenyl)-1,2,4-oxadiazol-5-yl]butan-2-yl2-aminoacetate; 
 (2R)-1,1,1-trifluoro-2-methyl-4-[3-(4-methyl-3-{7-methylimidazo[1,2-a]pyridine-3-amido}phenyl)-1,2,4-oxadiazol-5-yl]butan-2-yl(2R)-2-amino-3-methylbutanoate; 
 (2S)-1,1,1-trifluoro-2-methyl-4-[3-(4-methyl-3-{7-methylimidazo[1,2-a]pyridine-3-amido}phenyl)-1,2,4-oxadiazol-5-yl]butan-2-yl (2R)-2-amino-3-methylbutanoate; 
 7-methyl-N-{2-methyl-5-[5-(4,4,4-trifluoro-3-hydroxybutyl)-1,2,4-oxadiazol-3-yl]phenyl}imidazo[1,2-a]pyridine-3-carboxamide; 
 7-methyl-N-(2-methyl-5-{5-[3,3,3-trifluoro-2-hydroxy-2-(trifluoromethyl)propyl]-1,2,4-oxadiazol-3-yl}phenyl)imidazo[1,2-a]pyridine-3-carboxamide; 
 6-[1-(2-hydroxyethyl)-3,5-dimethyl-1H-pyrazol-4-yl]-N-[2-methyl-5-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl]imidazo[1,2-a]pyridine-3-carboxamide; 
 6-(5-acetyl-4-methyl-1,3-thiazol-2-yl)-N-[2-methyl-5-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl]imidazo[1,2-a]pyridine-3-carboxamide; 
 6-(3-methyl-1H-pyrazol-4-yl)-N-[2-methyl-5-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl]imidazo[1,2-a]pyridine-3-carboxamide; 
 N,4-dimethyl-2-(3-{[2-methyl-5-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl]carbamoyl}imidazo[1,2-a]pyridin-6-yl)-1,3-thiazole-5-carboxamide; 
 4-methyl-2-(3-{[2-methyl-5-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl]carbamoyl}imidazo[1,2-a]pyridin-6-yl)-1,3-thiazole-5-carboxamide; 
 6-{3,5-dimethyl-1-[(methylcarbamoyl)methyl]-1H-pyrazol-4-yl}-N-[2-methyl-5-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl]imidazo[1,2-a]pyridine-3-carboxamide; 
 ethyl 4-methyl-5-(3-{[2-methyl-5-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl]carbamoyl}imidazo[1,2-a]pyridin-6-yl)-1,3-thiazole-2-carboxylate; 
 4-methyl-5-(3-{[2-methyl-5-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl]carbamoyl}imidazo[1,2-a]pyridin-6-yl)-N-[2-(morpholin-4-yl)ethyl]-1,3-thiazole-2-carboxamide; 
 N-(2-hydroxyethyl)-4-methyl-5-(3-{[2-methyl-5-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl]carbamoyl}imidazo[1,2-a]pyridin-6-yl)-1,3-thiazole-2-carboxamide; 
 4-methyl-5-(3-{[2-methyl-5-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl]carbamoyl}imidazo[1,2-a]pyridin-6-yl)-1,3-thiazole-2-carboxamide; 
 6-[2-(hydroxymethyl)-4-methyl-1,3-thiazol-5-yl]-N-[2-methyl-5-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl]imidazo[1,2-a]pyridine-3-carboxamide; 
 N-(2-methyl-5-{5-[1-(2,2,2-trifluoroethoxy)ethyl]-1,2,4-oxadiazol-3-yl}phenyl)imidazo[1,2-a]pyridine-3-carboxamide; 
 dimethyl (2R)-1,1,1-trifluoro-2-methyl-4-[3-(4-methyl-3-{7-methylimidazo[1,2-a]pyridine-3-amido}phenyl)-1,2,4-oxadiazol-5-yl]butan-2-yl phosphate; 
 {[(2R)-1,1,1-trifluoro-2-methyl-4-[3-(4-methyl-3-{7-methylimidazo[1,2-a]pyridine-3-amido}phenyl)-1,2,4-oxadiazol-5-yl]butan-2-yl]oxy}phosphonic acid; 
 dimethyl (2S)-1,1,1-trifluoro-2-methyl-4-[3-(4-methyl-3-{7-methylimidazo[1,2-a]pyridine-3-amido}phenyl)-1,2,4-oxadiazol-5-yl]butan-2-yl phosphate; 
 {[(2S)-1,1,1-trifluoro-2-methyl-4-[3-(4-methyl-3-{7-methylimidazo[1,2-a]pyridine-3-amido}phenyl)-1,2,4-oxadiazol-5-yl]butan-2-yl]oxy}phosphonic acid, and 
 1,1,1-trifluoro-2-methyl-4-[3-(4-methyl-3-{7-methylimidazo[1,2-a]pyridine-3-amido}phenyl)-1,2,4-oxadiazol-5-yl]butan-2-yl (2S)-2-aminopropanoate. 
 
     
     
         25 . The compound of  claim 1  selected from:
 N-(5-{[5-(1-hydroxy-2-methylpropan-2-yl)-1,2,4-oxadiazol-3-yl]amino}-2-methylphenyl)imidazo[1,2-a]pyridine-3-carboxamide; 
 7-methyl-N-(2-methyl-5-{5-[(3S)-4,4,4-trifluoro-3-hydroxy-3-methylbutyl]-1,2,4-oxadiazol-3-yl}phenyl)imidazo[1,2-a]pyridine-3-carboxamide, and 
 7-methyl-N-(2-methyl-5-{5-[(3R)-4,4,4-trifluoro-3-hydroxy-3-methylbutyl]-1,2,4-oxadiazol-3-yl}phenyl)imidazo[1,2-a]pyridine-3-carboxamide. 
 
     
     
         26 . A pharmaceutical composition comprising a therapeutically effective amount a compound of  claim 1  and a pharmaceutically acceptable carrier. 
     
     
         27 . (canceled) 
     
     
         28 . (canceled) 
     
     
         29 . (canceled) 
     
     
         30 . (canceled) 
     
     
         31 . (canceled) 
     
     
         32 . (canceled) 
     
     
         33 . (canceled) 
     
     
         34 . (canceled) 
     
     
         35 . (canceled)