US2015011581A1PendingUtilityA1

Treatment of progressive neurodegenerative disease with ibudilast

Assignee: MEDICINOVA INCPriority: Jul 11, 2007Filed: Sep 19, 2014Published: Jan 8, 2015
Est. expiryJul 11, 2027(~1 yrs left)· nominal 20-yr term from priority
A61P 43/00A61P 25/16A61P 25/28A61P 25/14A61P 25/00A61P 21/00A61K 9/0019A61K 9/0053A61K 45/06A61K 9/0014A61K 31/437A61K 9/06
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Claims

Abstract

Compositions and methods for treating progressive neurodegenerative diseases, and their associated symptoms by administration of ibudilast (3-isobutyryl-2-isopropylpyrazolo[1,5-a]pyridine).

Claims

exact text as granted — not AI-modified
What is claimed is: 
     
         1 . A method of treating a patient diagnosed with amyotrophic lateral sclerosis (ALS) comprising administering to a patient in need thereof a therapeutically effective amount of ibudilast or a pharmaceutically acceptable salt thereof. 
     
     
         2 . The method of  claim 1  in which the ibudilast or pharmaceutically acceptable salt thereof is administered for at least six months. 
     
     
         3 . The method of  claim 1  in which the ibudilast or pharmaceutically acceptable salt thereof is administered for at least one year. 
     
     
         4 . The method of  claim 1  in which the ibudilast or pharmaceutically acceptable salt thereof is administered for at least two years. 
     
     
         5 . The method of  claim 1  in which the ibudilast or pharmaceutically acceptable salt thereof is administered at least once daily. 
     
     
         6 . The method of  claim 1  in which the ibudilast or pharmaceutically acceptable salt thereof is administered orally. 
     
     
         7 . The method of  claim 1  in which the ibudilast or pharmaceutically acceptable salt thereof is administered in an amount of 30 mg to 240 mg daily.

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