Antibodies to human transmembrane proteins

Abstract

The invention provides human transmembrane proteins (HTMPN) and polynucleotides which identify and encode HTMPN. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating, or preventing disorders associated with expression of HTMPN.

1 .- 20 . (canceled) 
     
     
         21 . An isolated antibody or fragment thereof that specifically binds to a polypeptide having at least 95% sequence identity to the amino acid sequence of SEQ ID NO:74. 
     
     
         22 . The isolated antibody or fragment thereof of  claim 21 , wherein the polypeptide comprises the amino acid sequence of SEQ ID NO:74. 
     
     
         23 . The isolated antibody or fragment thereof of  claim 21 , wherein the polypeptide consists of the amino acid sequence of SEQ ID NO:74. 
     
     
         24 . The isolated antibody or fragment thereof of  claim 21 , which is a monoclonal antibody. 
     
     
         25 . The isolated antibody or fragment thereof of  claim 21 , which is a Fab fragment. 
     
     
         26 . The isolated antibody or fragment thereof of  claim 21 , which is a F(ab′)2 fragment. 
     
     
         27 . The isolated antibody or fragment thereof of  claim 21 , which is a single-chain antibody. 
     
     
         28 . The isolated antibody or fragment thereof of  claim 21 , which is a chimeric antibody. 
     
     
         29 . The isolated antibody or fragment thereof of  claim 21 , which is a humanized antibody. 
     
     
         30 . The isolated antibody or fragment thereof of  claim 21 , which is labeled. 
     
     
         31 . The isolated antibody or fragment thereof of  claim 30 , wherein the antibody or fragment thereof is labeled by covalent or non-covalent attachment of a reporter molecule. 
     
     
         32 . The isolated antibody or fragment thereof of  claim 31 , wherein the reporter molecule is selected from the group consisting of radionuclides, enzymes, fluorescent, chemiluminescent, chromogenic agents, substrates, cofactors, inhibitors, and magnetic particles. 
     
     
         33 . A composition comprising the antibody or fragment thereof of  claim 21 , and a pharmaceutically acceptable carrier. 
     
     
         34 . A method for detecting in a sample the presence of a polypeptide having at least 95% sequence identity to the amino acid sequence of SEQ ID NO:74, wherein the method comprises:
 (a) contacting the sample with the antibody or fragment thereof of  claim 21  under conditions suitable for antibody-antigen complex formation; and   (b) detecting the complex formation, wherein the complex formation indicates the presence of the polypeptide in the sample.   
     
     
         35 . The method of  claim 34 , wherein the antibody or fragment thereof is labeled. 
     
     
         36 . The method of  claim 35 , wherein the antibody or fragment thereof is labeled by covalent or non-covalent attachment of a reporter molecule. 
     
     
         37 . The method of  claim 36 , wherein the reporter molecule is selected from the group consisting of radionuclides, enzymes, fluorescent, chemiluminescent, chromogenic agents, substrates, cofactors, inhibitors, and magnetic particles.