US2015018289A1PendingUtilityA1
Novel compounds and their effects on feeding behaviour
Est. expiryDec 13, 2026(~0.4 yrs left)· nominal 20-yr term from priority
Inventors:Stephen Robert Bloom
A61P 3/04A61P 43/00A61P 3/10C07K 14/605A61K 8/64A61K 38/02A61K 45/06A61K 38/00C07K 14/5759A61Q 19/06A61K 38/26C07K 14/575
57
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Claims
Abstract
The invention provides a peptide comprising the amino acid sequence given below, together with uses of the peptide and methods associated therewith. The peptide finds particular use as an appetite suppressant and in the treatment of obesity. Xaa1 Xaa2 Xaa3 Gly4 Thr5 Phe6 Thr7 Ser8 Asp9 Tyr10 Ser11 Lys12 Tyr13 Leu14 Xaa15 Xaa16 Xaa17 Xaa18 Xaa19 Xaa20 Xaa21 Xaa22 Xaa23 Xaa24 Trp25 Leu26 Xaa27 Xaa28 Xaa29 Xaa30 Xaa31 Xaa32 Lys33 Asn34 Asn35 Ile36 Ala37; wherein: Xaa1 is His1 or D-His1, Xaa2 is Ser2 or Ala2, Xaa3 is Gln3 or Asp3; Xaa15 Xaa16 Xaa17 Xaa18 Xaa19 Xaa20 Xaa21 Xaa22 Xaa23 Xaa24 is: Glu15 Glu16 Glu17 Leu18 Val19 Lys20 Tyr21 Phe22 Leu23 Glu24, Glu15 Glu16 Glu17 Leu18 Val19 Lys20 Tyr21 Phe22 Leu23 Gln24, Glu15 Glu16 Glu17 Leu18 Val19 Lys20 Tyr21 Phe22 Ile23 Glu24, Glu15 Glu16 Glu17 Leu18 Val19 Lys20 Tyr21 Phe22 Ile23 Gln24, Glu15 Glu16 Glu17 Ile18 Val19 Lys20 Tyr21 Phe22 Leu23 Glu24, Glu15 Glu16 Glu17 Ile18 Val19 Lys20 Tyr21 Phe22 Leu23 Gln24, Glu15 Glu16 Glu17 Ile18 Val19 Lys20 Tyr21 Phe22 Ile23 Glu24, Clu15 Glu16 Glu17 Ile18 Val19 Lys20 Tyr21 Phe22 Ile23 Gln24, Glu15 Gln16 Glu17 Leu18 Val19 Lys20 Tyr21 Phe22 Leu23 Glu24, Glu15 Gln16 Glu17 Leu18 Val19 Lys20 Tyr21 Phe22 Leu23 Gln24, Glu15 Gln16 Glu17 Leu18 Val19 Lys20 Tyr21 Phe22 Ile23 Glu24, Glu15 Gln16 Glu17 Leu18 Val19 Lys20 Tyr21 Phe22 Ile23 Gln24, Glu15 Gln16 Glu17 Ile18 Val19 Lys20 Tyr21 Phe22 Leu23 Glu24, Glu15 Gln16 Glu17 Ile18 Val19 Lys20 Tyr21 Phe22 Leu23 Gln24, Glu15 Gln16 Glu17 Ile18 Val19 Lys20 Tyr21 Phe22 Ile23 Glu24, Glu15 Gln16 Glu17 Ile18 Val19 Lys20 Tyr21 Phe22 Ile23 Gln24, Asp15 Ser16 Arg17 Arg18 Ala19 Gln20 Asp21 Phe22 Val23 Gln24; or Xaa27 Xaa28 Xaa29 Xaa30 Xaa31 Xaa32 is: Met27 Asn28 Thr29 Lys30 Arg31 Asn32, Lys27 Asn28 Ala29 Gly30 Pro31 Ser32, Lys27 Asn28 Gly29 Gly30 Pro31 Ser32 or or a peptide as set out above in which residue Asn34 is replaced with Asp34; or a peptide as set out above in which Xaa3 is Glu3; with the proviso that if Xaa15 Xaa16 Xaa17 Xaa18 Xaa19 Xaa20 Xaa21 Xaa22 Xaa23 Xaa24 is Asp15 Ser16 Arg17 Arg18 Ala19 Gln20 Asp21 Phe22 Val23 Gln24, then Xaa27 Xaa28 Xaa29 Xaa30 Xaa31 Xaa32 is not Met27 Asn28 Thr29 Lys30 Arg31 Asn32.
Claims
exact text as granted — not AI-modified1 . A peptide comprising the amino acid sequence:
Xaa1 Xaa2 Xaa3 Gly4 Thr5 Phe6 Thr7 Ser8 Asp9 Tyr10
Ser11 Lys12 Tyr13 Leu14 Xaa15 Xaa16 Xaa17 Xaa18
Xaa19 Xaa20 Xaa21 Xaa22 Xaa23 Xaa24 Trp25 Leu26
Xaa27 Xaa28 Xaa29 Xaa30 Xaa31 Xaa32 Lys33 Asn34
Asn35 Ile36 Ala37;
wherein:
Xaa1 is His1 or D-His1,
Xaa2 is Ser2 or Ala2,
Xaa3 is Gln3 or Asp3;
Xaa15 Xaa16 Xaa17 Xaa18 Xaa19 Xaa20 Xaa21 Xaa22 Xaa23 Xaa24 is:
Glu15 Glu16 Glu17 Leu18 Val19 Lys20 Tyr21 Phe22 Leu23 Glu24,
Glu15 Glu16 Glu17 Leu18 Val19 Lys20 Tyr21 Phe22 Leu23 Gln24,
Glu15 Glu16 Glu17 Leu18 Val19 Lys20 Tyr21 Phe22 Ile23 Glu24,
Glu15 Glu16 Glu17 Leu18 Val19 Lys20 Tyr21 Phe22 Ile23 Gln24,
Glu15 Glu16 Glu17 Ile18 Val19 Lys20 Tyr21 Phe22 Leu23 Glu24,
Glu15 Glu16 Glu17 Ile18 Val19 Lys20 Tyr21 Phe22 Leu23 Gln24,
Glu15 Glu16 Glu17 Ile18 Val19 Lys20 Tyr21 Phe22 Ile23 Glu24,
Glu15 Glu16 Glu17 Ile18 Val19 Lys20 Tyr21 Phe22 Ile23 Gln24,
Glu15 Gln16 Glu17 Leu18 Val19 Lys20 Tyr21 Phe22 Leu23 Glu24,
Glu15 Gln16 Glu17 Leu18 Val19 Lys20 Tyr21 Phe22 Leu23 Gln24,
Glu15 Gln16 Glu17 Leu18 Val19 Lys20 Tyr21 Phe22 Ile23 Glu24,
Glu15 Gln16 Glu17 Leu18 Val19 Lys20 Tyr21 Phe22 Ile23 Gln24,
Glu15 Gln16 Glu17 Ile18 Val19 Lys20 Tyr21 Phe22 Leu23 Glu24,
Glu15 Gln16 Glu17 Ile18 Val19 Lys20 Tyr21 Phe22 Leu23 Gln24,
Glu15 Gln16 Glu17 Ile18 Val19 Lys20 Tyr21 Phe22 Ile23 Glu24,
Glu15 Gln16 Glu17 Ile18 Val19 Lys20 Tyr21 Phe22 Ile23 Gln24,
or Asp15 Ser16 Arg17 Arg18 Ala19 Gln20 Asp21 Phe22 Val23 Gln24;
Xaa27 Xaa28 Xaa29 Xaa30 Xaa31 Xaa32 is:
Met27 Asn28 Thr29 Lys30 Arg31 Asn32,
Lys27 Asn28 Ala29 Gly30 Pro31 Ser32,
or Lys27 Asn28 Gly29 Gly30 Pro31 Ser32
or a peptide as set out above in which residue Asn34 is replaced with Asp34;
or a peptide as set out above in which Xaa3 is Glu3;
with the proviso that if
Xaa15 Xaa16 Xaa17 Xaa18 Xaa19 Xaa20 Xaa21 Xaa22 Xaa23 Xaa24 is
Asp15 Ser16 Arg17 Arg18 Ala19 Gln20 Asp21 Phe22 Val23 Gln24,
then Xaa27 Xaa28 Xaa29 Xaa30 Xaa31 Xaa32 is not
Met27 Asn28 Thr29 Lys30 Arg31 Asn32
(SEQ ID NO: 356).
2 . A peptide as claimed in claim 1 , wherein
Xaa15 Xaa16 Xaa17 Xaa18 Xaa19 Xaa20 Xaa21 Xaa22 Xaa23 Xaa24 is: Glu15 Glu16 Glu17 Leu18 Val19 Lys20 Tyr21 Phe22 Leu23 Glu24, Glu15 Glu16 Glu17 Leu18 Val19 Lys20 Tyr21 Phe22 Leu23 Gln24, Glu15 Glu16 Glu17 Leu18 Val19 Lys20 Tyr21 Phe22 Ile23 Glu24, Glu15 Glu16 Glu17 Leu18 Val19 Lys20 Tyr21 Phe22 Ile23 Gln24, Glu15 Glu16 Glu17 Ile18 Val19 Lys20 Tyr21 Phe22 Leu23 Glu24, Glu15 Glu16 Glu17 Ile18 Val19 Lys20 Tyr21 Phe22 Leu23 Gln24, Glu15 Glu16 Glu17 Ile18 Val19 Lys20 Tyr21 Phe22 Ile23 Glu24, Glu15 Glu16 Glu17 Ile18 Val19 Lys20 Tyr21 Phe22 Ile23 Gln24, Glu15 Gln16 Glu17 Leu18 Val19 Lys20 Tyr21 Phe22 Leu23 Glu24, Glu15 Gln16 Glu17 Leu18 Val19 Lys20 Tyr21 Phe22 Leu23 Gln24, Glu15 Gln16 Glu17 Leu18 Val19 Lys20 Tyr21 Phe22 Ile23 Glu24, Glu15 Gln16 Glu17 Leu18 Val19 Lys20 Tyr21 Phe22 Ile23 Gln24, Glu15 Gln16 Glu17 Ile18 Val19 Lys20 Tyr21 Phe22 Leu23 Glu24, Glu15 Gln16 Glu17 Ile18 Val19 Lys20 Tyr21 Phe22 Leu23 Gln24, Glu15 Gln16 Glu17 Ile18 Val19 Lys20 Tyr21 Phe22 Ile23 Glu24,
or Glu15 Gln16 Glu17 Ile18 Val19 Lys20 Tyr21 Phe22 Ile23 Gln24
(SEQ ID NO: 359).
3 . A peptide as claimed in claim 1 , wherein
Xaa1 Xaa2 Xaa3 is His1 Ser2 Gln3, or. D-His1 Ser2 Gln3, or D-His1 Ala2 Gln3, or D-His1 Ala2 Asp3 (SEQ ID NO: 360).
4 . A peptide as claimed in claim 1 , wherein
Xaa27 Xaa28 Xaa29 Xaa30 Xaa31 Xaa32 is: Lys27 Asn28 Ala29 Gly30 Pro31 Ser32,
or Lys27 Asn28 Gly29 Gly30 Pro31 Ser32
(SEQ ID NO: 361).
5 . A peptide as claimed in claim 1 having an amino acid sequence selected from the group consisting of:
(SEQ ID NO: 1)
His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys Tyr
Phe Leu Glu Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 2)
His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys Tyr
Phe Leu Glu Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 3)
His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys Tyr
Phe Leu Glu Trp Leu Met Asn Thr Lys Arg Asn Lys Asn Asn Ile Ala
(SEQ ID NO: 4)
His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys Tyr
Phe Leu Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 5)
His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys Tyr
Phe Leu Gln Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 6)
His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys Tyr
Phe Leu Gln Trp Leu Met Asn Thr Lys Arg Asn Lys Asn Asn Ile Ala
(SEQ ID NO: 7)
His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys Tyr
Phe Ile Glu Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 8)
His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys Tyr
Phe Ile Glu Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 9
His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys Tyr
Phe Ile Glu Trp Leu Met Asn Thr Lys Arg Asn Lys Asn Asn Ile Ala
(SEQ ID NO: 10)
His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys Tyr
Phe Ile Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 11)
His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys Tyr
Phe Ile Gln Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 12)
His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys Tyr
Phe Ile Gln Trp Leu Met Asn Thr Lys Arg Asn Lys Asn Asn Ile Ala
(SEQ ID NO: 13)
His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Ile Val Lys Tyr Phe
Leu Glu Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 14)
His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Ile Val Lys Tyr Phe
Leu Glu Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 15)
His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Ile Val Lys Tyr Phe
Leu Glu Trp Leu Met Asn Thr Lys Arg Asn Lys Asn Asn Ile Ala
(SEQ ID NO: 16)
His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Ile Val Lys Tyr Phe
Leu Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 17)
His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Ile Val Lys Tyr Phe
Leu Gln Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 18)
His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Ile Val Lys Tyr Phe
Leu Gln Trp Leu Met Asn Thr Lys Arg Asn Lys Asn Asn Ile Ala
(SEQ ID NO: 19)
His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Ile Val Lys Tyr Phe
Ile Glu Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 20)
His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Ile Val Lys Tyr Phe
Ile Glu Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 21)
His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Ile Val Lys Tyr Phe
Ile Glu Trp Leu Met Asn Thr Lys Arg Asn Lys Asn Asn Ile Ala
(SEQ ID NO: 22)
His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Ile Val Lys Tyr Phe
Ile Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 23)
His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Ile Val Lys Tyr Phe
Ile Gln Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 24)
His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Ile Val Lys Tyr Phe
Ile Gln Trp Leu Met Asn Thr Lys Arg Asn Lys Asn Asn Ile Ala
(SEQ ID NO: 25)
His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Leu Val Lys Tyr
Phe Leu Glu Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 26)
His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Leu Val Lys Tyr
Phe Leu Glu Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 27)
His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Leu Val Lys Tyr
Phe Leu Glu Trp Leu Met Asn Thr Lys Arg Asn Lys Asn Asn Ile Ala
(SEQ ID NO: 28)
His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Leu Val Lys Tyr
Phe Leu Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 29)
His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Leu Val Lys Tyr
Phe Leu Gln Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 30)
His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Leu Val Lys Tyr
Phe Leu Gln Trp Leu Met Asn Thr Lys Arg Asn Lys Asn Asn Ile Ala
(SEQ ID NO: 31)
His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Leu Val Lys Tyr
Phe Ile Glu Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 32)
His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Leu Val Lys Tyr
Phe Ile Glu Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 33)
His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Leu Val Lys Tyr
Phe Ile Glu Trp Leu Met Asn Thr Lys Arg Asn Lys Asn Asn Ile Ala
(SEQ ID NO: 34)
His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Leu Val Lys Tyr
Phe Ile Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 35)
His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Leu Val Lys Tyr
Phe Ile Gln Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 36)
His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Leu Val Lys Tyr
Phe Ile Gln Trp Leu Met Asn Thr Lys Arg Asn Lys Asn Asn Ile Ala
(SEQ ID NO: 37)
His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Ile Val Lys Tyr Phe
Leu Glu Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 38)
His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Ile Val Lys Tyr Phe
Leu Glu Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 39)
His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Ile Val Lys Tyr Phe
Leu Glu Trp Leu Met Asn Thr Lys Arg Asn Lys Asn Asn Ile Ala
(SEQ ID NO: 40)
His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Ile Val Lys Tyr Phe
Leu Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 41)
His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Ile Val Lys Tyr Phe
Leu Gln Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 42)
His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Ile Val Lys Tyr Phe
Leu Gln Trp Leu Met Asn Thr Lys Arg Asn Lys Asn Asn Ile Ala
(SEQ ID NO: 43)
His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Ile Val Lys Tyr Phe
Ile Glu Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 44)
His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Ile Val Lys Tyr Phe
Ile Glu Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 45)
His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Ile Val Lys Tyr Phe
Ile Glu Trp Leu Met Asn Thr Lys Arg Asn Lys Asn Asn Ile Ala
(SEQ ID NO: 46)
His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Ile Val Lys Tyr Phe
Ile Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 47)
His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Ile Val Lys Tyr Phe
Ile Gln Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 48)
His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Ile Val Lys Tyr Phe
Ile Gln Trp Leu Met Asn Thr Lys Arg Asn Lys Asn Asn Ile Ala
(SEQ ID NO: 49)
D-His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys Tyr
Phe Leu Glu Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 50)
D-His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys Tyr
Phe Leu Glu Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 51)
D-His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys Tyr
Phe Leu Glu Trp Leu Met Asn Thr Lys Arg Asn Lys Asn Asn Ile Ala
(SEQ ID NO: 52)
D-His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys Tyr
Phe Leu Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 53)
D-His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys Tyr
Phe Leu Gln Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 54)
D-His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys Tyr
Phe Leu Gln Trp Leu Met Asn Thr Lys Arg Asn Lys Asn Asn Ile Ala
(SEQ ID NO: 55)
D-His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys Tyr
Phe Ile Glu Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 56)
D-His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys Tyr
Phe Ile Glu Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 57)
D-His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys Tyr
Phe Ile Glu Trp Leu Met Asn Thr Lys Arg Asn Lys Asn Asn Ile Ala
(SEQ ID NO: 58)
D-His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys Tyr
Phe Ile Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 59
D-His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys Tyr
Phe Ile Gln Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 60
D-His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys Tyr
Phe Ile Gln Trp Leu Met Asn Thr Lys Arg Asn Lys Asn Asn Ile Ala
(SEQ ID NO: 61
D-His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Ile Val Lys Tyr
Phe Leu Glu Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 62)
D-His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Ile Val Lys Tyr
Phe Leu Glu Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 63)
D-His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Ile Val Lys Tyr
Phe Leu Glu Trp Leu Met Asn Thr Lys Arg Asn Lys Asn Asn Ile Ala
(SEQ ID NO: 64)
D-His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Ile Val Lys Tyr
Phe Leu Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 65)
D-His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Ile Val Lys Tyr
Phe Leu Gln Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 66)
D-His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Ile Val Lys Tyr
Phe Leu Gln Trp Leu Met Asn Thr Lys Arg Asn Lys Asn Asn Ile Ala
(SEQ ID NO: 67)
D-His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Ile Val Lys Tyr
Phe Ile Glu Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 68)
D-His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Ile Val Lys Tyr
Phe Ile Glu Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 69)
D-His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Ile Val Lys Tyr
Phe Ile Glu Trp Leu Met Asn Thr Lys Arg Asn Lys Asn Asn Ile Ala
(SEQ ID NO: 70)
D-His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Ile Val Lys Tyr
Phe Ile Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 71)
D-His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Ile Val Lys Tyr
Phe Ile Gln Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 72)
D-His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Ile Val Lys Tyr
Phe Ile Gln Trp Leu Met Asn Thr Lys Arg Asn Lys Asn Asn Ile Ala
(SEQ ID NO: 73)
D-His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Leu Val Lys Tyr
Phe Leu Glu Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 74)
D-His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Leu Val Lys Tyr
Phe Leu Glu Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 75)
D-His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Leu Val Lys Tyr
Phe Leu Glu Trp Leu Met Asn Thr Lys Arg Asn Lys Asn Asn Ile Ala
(SEQ ID NO: 76)
D-His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Leu Val Lys Tyr
Phe Leu Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 77)
D-His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Leu Val Lys Tyr
Phe Leu Gln Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 78)
D-His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Leu Val Lys Tyr
Phe Leu Gln Trp Leu Met Asn Thr Lys Arg Asn Lys Asn Asn Ile Ala
(SEQ ID NO: 79)
D-His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Leu Val Lys Tyr
Phe Ile Glu Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 80)
D-His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Leu Val Lys Tyr
Phe Ile Glu Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 81)
D-His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Leu Val Lys Tyr
Phe Ile Glu Trp Leu Met Asn Thr Lys Arg Asn Lys Asn Asn Ile Ala
(SEQ ID NO: 82)
D-His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Leu Val Lys Tyr
Phe Ile Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 83)
D-His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Leu Val Lys Tyr
Phe Ile Gln Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 84)
D-His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Leu Val Lys Tyr
Phe Ile Gln Trp Leu Met Asn Thr Lys Arg Asn Lys Asn Asn Ile Ala
(SEQ ID NO: 85)
D-His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Ile Val Lys Tyr
Phe Leu Glu Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 86)
D-His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Ile Val Lys Tyr
Phe Leu Glu Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 87)
D-His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Ile Val Lys Tyr
Phe Leu Glu Trp Leu Met Asn Thr Lys Arg Asn Lys Asn Asn Ile Ala
(SEQ ID NO: 88)
D-His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Ile Val Lys Tyr
Phe Leu Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 89)
D-His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Ile Val Lys Tyr
Phe Leu Gln Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 90)
D-His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Ile Val Lys Tyr
Phe Leu Gln Trp Leu Met Asn Thr Lys Arg Asn Lys Asn Asn Ile Ala
(SEQ ID NO: 91)
D-His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Ile Val Lys Tyr
Phe Ile Glu Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 92)
D-His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Ile Val Lys Tyr
Phe Ile Glu Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 93)
D-His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Ile Val Lys Tyr
Phe Ile Glu Trp Leu Met Asn Thr Lys Arg Asn Lys Asn Asn Ile Ala
(SEQ ID NO: 94)
D-His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Ile Val Lys Tyr
Phe Ile Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 95)
D-His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Ile Val Lys Tyr
Phe Ile Gln Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 96)
D-His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Ile Val Lys Tyr
Phe Ile Gln Trp Leu Met Asn Thr Lys Arg Asn Lys Asn Asn Ile Ala
(SEQ ID NO: 97)
D-His Ala Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys Tyr
Phe Leu Glu Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 98)
D-His Ala Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys Tyr
Phe Leu Glu Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 99)
D-His Ala Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys Tyr
Phe Leu Glu Trp Leu Met Asn Thr Lys Arg Asn Lys Asn Asn Ile Ala
(SEQ ID NO: 100)
D-His Ala Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys Tyr
Phe Leu Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 101)
D-His Ala Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys Tyr
Phe Leu Gln Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 102)
D-His Ala Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys Tyr
Phe Leu Gln Trp Leu Met Asn Thr Lys Arg Asn Lys Asn Asn Ile Ala
(SEQ ID NO: 103)
D-His Ala Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys Tyr
Phe Ile Glu Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 104)
D-His Ala Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys Tyr
Phe Ile Glu Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 105)
D-His Ala Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys Tyr
Phe Ile Glu Trp Leu Met Asn Thr Lys Arg Asn Lys Asn Asn Ile Ala
(SEQ ID NO: 106)
D-His Ala Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys Tyr
Phe Ile Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 107)
D-His Ala Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys Tyr
Phe Ile Gln Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 108)
D-His Ala Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys Tyr
Phe Ile Gln Trp Leu Met Asn Thr Lys Arg Asn Lys Asn Asn Ile Ala
(SEQ ID NO: 109)
D-His Ala Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Ile Val Lys Tyr
Phe Leu Glu Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 110)
D-His Ala Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Ile Val Lys Tyr
Phe Leu Glu Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 111)
D-His Ala Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Ile Val Lys Tyr
Phe Leu Glu Trp Leu Met Asn Thr Lys Arg Asn Lys Asn Asn Ile Ala
(SEQ ID NO: 112)
D-His Ala Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Ile Val Lys Tyr
Phe Leu Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 113)
D-His Ala Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Ile Val Lys Tyr
Phe Leu Gln Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 114)
D-His Ala Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Ile Val Lys Tyr
Phe Leu Gln Trp Leu Met Asn Thr Lys Arg Asn Lys Asn Asn Ile Ala
(SEQ ID NO: 115)
D-His Ala Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Ile Val Lys Tyr
Phe Ile Glu Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 116)
D-His Ala Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Ile Val Lys Tyr
Phe Ile Glu Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 117)
D-His Ala Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Ile Val Lys Tyr
Phe Ile Glu Trp Leu Met Asn Thr Lys Arg Asn Lys Asn Asn Ile Ala
(SEQ ID NO: 118)
D-His Ala Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Ile Val Lys Tyr
Phe Ile Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 119)
D-His Ala Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Ile Val Lys Tyr
Phe Ile Gln Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 120)
D-His Ala Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Ile Val Lys Tyr
Phe Ile Gln Trp Leu Met Asn Thr Lys Arg Asn Lys Asn Asn Ile Ala
(SEQ ID NO: 121)
D-His Ala Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Leu Val Lys Tyr
Phe Leu Glu Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 122)
D-His Ala Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Leu Val Lys Tyr
Phe Leu Glu Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 123)
D-His Ala Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Leu Val Lys Tyr
Phe Leu Glu Trp Leu Met Asn Thr Lys Arg Asn Lys Asn Asn Ile Ala
(SEQ ID NO: 124)
D-His Ala Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Leu Val Lys Tyr
Phe Leu Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 125)
D-His Ala Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Leu Val Lys Tyr
Phe Leu Gln Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 126)
D-His Ala Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Leu Val Lys Tyr
Phe Leu Gln Trp Leu Met Asn Thr Lys Arg Asn Lys Asn Asn Ile Ala
(SEQ ID NO: 127)
D-His Ala Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Leu Val Lys Tyr
Phe Ile Glu Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 128)
D-His Ala Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Leu Val Lys Tyr
Phe Ile Glu Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 129)
D-His Ala Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Leu Val Lys Tyr
Phe Ile Glu Trp Leu Met Asn Thr Lys Arg Asn Lys Asn Asn Ile Ala
(SEQ ID NO: 130)
D-His Ala Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Leu Val Lys Tyr
Phe Ile Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 131)
D-His Ala Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Leu Val Lys Tyr
Phe Ile Gln Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 132)
D-His Ala Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Leu Val Lys Tyr
Phe Ile Gln Trp Leu Met Asn Thr Lys Arg Asn Lys Asn Asn Ile Ala
(SEQ ID NO: 133)
D-His Ala Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Ile Val Lys Tyr
Phe Leu Glu Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 134)
D-His Ala Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Ile Val Lys Tyr
Phe Leu Glu Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 135)
D-His Ala Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Ile Val Lys Tyr
Phe Leu Glu Trp Leu Met Asn Thr Lys Arg Asn Lys Asn Asn Ile Ala
(SEQ ID NO: 136)
D-His Ala Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Ile Val Lys Tyr
Phe Leu Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 137)
D-His Ala Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Ile Val Lys Tyr
Phe Leu Gln Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 138)
D-His Ala Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Ile Val Lys Tyr
Phe Leu Gln Trp Leu Met Asn Thr Lys Arg Asn Lys Asn Asn Ile Ala
(SEQ ID NO: 139)
D-His Ala Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Ile Val Lys Tyr
Phe Ile Glu Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 140)
D-His Ala Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Ile Val Lys Tyr
Phe Ile Glu Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 141)
D-His Ala Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Ile Val Lys Tyr
Phe Ile Glu Trp Leu Met Asn Thr Lys Arg Asn Lys Asn Asn Ile Ala
(SEQ ID NO: 142)
D-His Ala Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Ile Val Lys Tyr
Phe Ile Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 143)
D-His Ala Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Ile Val Lys Tyr
Phe Ile Gln Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 144)
D-His Ala Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Ile Val Lys Tyr
Phe Ile Gln Trp Leu Met Asn Thr Lys Arg Asn Lys Asn Asn Ile Ala
(SEQ ID NO: 145)
D-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys Tyr
Phe Leu Glu Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 146)
D-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys Tyr
Phe Leu Glu Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 147)
D-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys Tyr
Phe Leu Glu Trp Leu Met Asn Thr Lys Arg Asn Lys Asn Asn Ile Ala
(SEQ ID NO: 148)
D-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys Tyr
Phe Leu Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 149)
D-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys Tyr
Phe Leu Gln Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 150)
D-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys Tyr
Phe Leu Gln Trp Leu Met Asn Thr Lys Arg Asn Lys Asn Asn Ile Ala
(SEQ ID NO: 151)
D-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys Tyr
Phe Ile Glu Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 152)
D-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys Tyr
Phe Ile Glu Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 153)
D-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys Tyr
Phe Ile Glu Trp Leu Met Asn Thr Lys Arg Asn Lys Asn Asn Ile Ala
(SEQ ID NO: 154)
D-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys Tyr
Phe Ile Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 155)
D-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys Tyr
Phe Ile Gln Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 156)
D-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys Tyr
Phe Ile Gln Trp Leu Met Asn Thr Lys Arg Asn Lys Asn Asn Ile Ala
(SEQ ID NO: 157)
D-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Ile Val Lys Tyr
Phe Leu Glu Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 158)
D-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Ile Val Lys Tyr
Phe Leu Glu Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 159)
D-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Ile Val Lys Tyr
Phe Leu Glu Trp Leu Met Asn Thr Lys Arg Asn Lys Asn Asn Ile Ala
(SEQ ID NO: 160)
D-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Ile Val Lys Tyr
Phe Leu Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 161)
D-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Ile Val Lys Tyr
Phe Leu Gln Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 162)
D-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Ile Val Lys Tyr
Phe Leu Gln Trp Leu Met Asn Thr Lys Arg Asn Lys Asn Asn Ile Ala
(SEQ ID NO: 163)
D-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Ile Val Lys Tyr
Phe Ile Glu Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 164)
D-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Ile Val Lys Tyr
Phe Ile Glu Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 165)
D-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Ile Val Lys Tyr
Phe Ile Glu Trp Leu Met Asn Thr Lys Arg Asn Lys Asn Asn Ile Ala
(SEQ ID NO: 166)
D-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Ile Val Lys Tyr
Phe Ile Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 167)
D-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Ile Val Lys Tyr
Phe Ile Gln Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 168)
D-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Ile Val Lys Tyr
Phe Ile Gln Trp Leu Met Asn Thr Lys Arg Asn Lys Asn Asn Ile Ala
(SEQ ID NO: 169)
D-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Leu Val Lys Tyr
Phe Leu Glu Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 170)
D-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Leu Val Lys Tyr
Phe Leu Glu Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 171)
D-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Leu Val Lys Tyr
Phe Leu Glu Trp Leu Met Asn Thr Lys Arg Asn Lys Asn Asn Ile Ala
(SEQ ID NO: 172)
D-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Leu Val Lys Tyr
Phe Leu Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 173)
D-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Leu Val Lys Tyr
Phe Leu Gln Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 174)
D-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Leu Val Lys Tyr
Phe Leu Gln Trp Leu Met Asn Thr Lys Arg Asn Lys Asn Asn Ile Ala
(SEQ ID NO: 175)
D-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Leu Val Lys Tyr
Phe Ile Glu Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 176)
D-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Leu Val Lys Tyr
Phe Ile Glu Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 177)
D-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Leu Val Lys Tyr
Phe Ile Glu Trp Leu Met Asn Thr Lys Arg Asn Lys Asn Asn Ile Ala
(SEQ ID NO: 178)
D-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Leu Val Lys Tyr
Phe Ile Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 179)
D-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Leu Val Lys Tyr
Phe Ile Gln Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 180)
D-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Leu Val Lys Tyr
Phe Ile Gln Trp Leu Met Asn Thr Lys Arg Asn Lys Asn Asn Ile Ala
(SEQ ID NO: 181)
D-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Ile Val Lys Tyr
Phe Leu Glu Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 182)
D-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Ile Val Lys Tyr
Phe Leu Glu Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 183)
D-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Ile Val Lys Tyr
Phe Leu Glu Trp Leu Met Asn Thr Lys Arg Asn Lys Asn Asn Ile Ala
(SEQ ID NO: 184)
D-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Ile Val Lys Tyr
Phe Leu Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 185)
D-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Ile Val Lys Tyr
Phe Leu Gln Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 186)
D-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Ile Val Lys Tyr
Phe Leu Gln Trp Leu Met Asn Thr Lys Arg Asn Lys Asn Asn Ile Ala
(SEQ ID NO: 187)
D-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Ile Val Lys Tyr
Phe Ile Glu Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 188)
D-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Ile Val Lys Tyr
Phe Ile Glu Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 189)
D-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Ile Val Lys Tyr
Phe Ile Glu Trp Leu Met Asn Thr Lys Arg Asn Lys Asn Asn Ile Ala
(SEQ ID NO: 190)
D-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Ile Val Lys Tyr
Phe Ile Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 191)
D-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Ile Val Lys Tyr
Phe Ile Gln Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 192)
D-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Ile Val Lys Tyr
Phe Ile Gln Trp Leu Met Asn Thr Lys Arg Asn Lys Asn Asn Ile Ala
6 . A peptide as claimed in claim 1 , wherein the peptide has an additional extension moiety of sequence -A-B-C, wherein:
A is absent or 1, 2, 3 or 4 Ala residues or 1, 2, 3 or 4 Glu residues B is absent or 1, 2, 3 or 4 Ala residues or 1, 2, 3 or 4 Glu residues
provided that A and B do not both comprise Ala residues, and that A and B do not both comprise Glu residues; and
C is Lys, or Lys with an acid selected from capric acid, lauric acid, myristic acid, palmitic acid, stearic acid and arachidic acid, attached via its —COOH group to the —NH 2 group of the Lys side chain by means of a peptide bond.
7 . A peptide as claimed in claim 6 , wherein A or B or both A and B are absent.
8 . A peptide as claimed in claim 6 , wherein A is one Glu residue, and B is one Ala residue.
9 . A peptide as claimed in claim 6 , wherein C is a Lys residue.
10 . A peptide as claimed in claim 6 , wherein:
C is a Lys residue with lauric acid attached via its —COOH group to the —NH2 group of the Lys side chain by means of a peptide bond; C is a Lys residue with myristic acid attached via its —COOH group to the —NH2 group of the Lys side chain by means of a peptide bond; C is a Lys residue with palmitic acid attached via its —COOH group to the —NH2 group of the Lys side chain by means of a peptide bond; C is a Lys residue with stearic acid attached via its —COOH group to the —NH2 group of the Lys side chain by means of a peptide bond; C is a Lys residue with arachidic acid attached via its —COOH group to the —NH2 group of the Lys side chain by means of a peptide bond; or C is a Lys residue with capric acid attached via its —COOH group to the —NH2 group of the Lys side chain by means of a peptide bond.
11 . A peptide according to claim 6 having a structure sequence selected from the group consisting of:
(SEQ ID NO: 201)
D-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Ile Val Lys Tyr
Phe Ile Gln Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala Lys
(SEQ ID NO: 202)
D-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Ile Val Lys Tyr
Phe Ile Gln Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala Lys
(SEQ ID NO: 203)
D-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Ile Val Lys Tyr
Phe Ile Gln Trp Leu Met Asn Thr Lys Arg Asn Lys Asn Asn Ile Ala Lys
(SEQ ID NO: 204)
D-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys Tyr
Phe Ile Gln Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala Lys
(SEQ ID NO: 205)
D-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Leu Val Lys Tyr
Phe Ile Gln Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala Lys
(SEQ ID NO: 206)
D-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys Tyr
Phe Ile Gln Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala Ala Ala Lys-myristoyl
(SEQ ID NO: 207)
D-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys Tyr
Phe Ile Gln Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala Ala Ala Lys-palmitoyl
(SEQ ID NO: 208)
D-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys Tyr
Phe Ile Gln Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala Ala Ala Lys-stearoyl
(SEQ ID NO: 209)
D-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys Tyr
Phe Ile Gln Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala Ala Ala Lys-arachidoyl
(SEQ ID NO: 210)
D-His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys Tyr
Phe Leu Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala Glu Ala Lys
(SEQ ID NO: 211)
D-His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys Tyr
Phe Leu Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala Glu Ala Lys-myristoyl
(SEQ ID NO: 212)
L-His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys Tyr
Phe Leu Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala Glu Ala Lys-myristoyl
(SEQ ID NO: 213)
D-His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys Tyr
Phe Leu Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala Glu Ala Lys-palmitoyl
(SEQ ID NO: 214)
D-His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys Tyr
Phe Leu Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala Glu Ala Lys-arachidoyl
12 . A peptide according to claim 1 having a structure sequence selected from the group consisting of:
(SEQ ID NO: 215)
D-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Ile Val Lys Tyr
Phe Ile Glu Trp Leu Lys Asn Gly Gly Pro Ser Lys Asp Asn Ile Ala
(SEQ ID NO: 216)
D-His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys Tyr
Phe Leu Glu Trp Leu Lys Asn Ala Gly Pro Ser Lys Asp Asn Ile Ala
(SEQ ID NO: 217)
D-His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys Tyr
Phe Leu Glu Trp Leu Lys Asn Gly Gly Pro Ser Lys Asp Asn Ile Ala
(SEQ ID NO: 218)
D-His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys Tyr
Phe Leu Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asp Asn Ile Ala
(SEQ ID NO: 219)
D-His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Ile Val Lys Tyr
Phe Ile Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asp Asn Ile Ala
(SEQ ID NO: 220)
D-His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys Tyr
Phe Leu Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asp Asn Ile Ala
(SEQ ID NO: 221)
D-His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys Tyr
Phe Ile Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asp Asn Ile Ala
(SEQ ID NO: 222)
D-His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys Tyr
Phe Ile Gln Trp Leu Met Asn Thr Lys Arg Asn Lys Asp Asn Ile Ala
(SEQ ID NO: 223)
D-His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Leu Val Lys Tyr
Phe Ile Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asp Asn Ile Ala
(SEQ ID NO: 224)
D-His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Ile Val Lys Tyr
Phe Ile Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asp Asn Ile Ala
(SEQ ID NO: 225)
D-His Ala Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys Tyr
Phe Leu Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asp Asn Ile Ala
(SEQ ID NO: 226)
D-His Ala Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys Tyr
Phe Ile Gln Trp Leu Met Asn Thr Lys Arg Asn Lys Asp Asn Ile Ala
(SEQ ID NO: 227)
D-His Ala Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Leu Val Lys Tyr
Phe Ile Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asp Asn Ile Ala
(SEQ ID NO: 228)
D-His Ala Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Ile Val Lys Tyr
Phe Leu Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asp Asn Ile Ala
(SEQ ID NO: 229)
D-His Ala Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Ile Val Lys Tyr
Phe Leu Gln Trp Leu Lys Asn Gly Gly Pro Ser Lys Asp Asn Ile Ala
(SEQ ID NO: 230)
D-His Ala Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Ile Val Lys Tyr
Phe Ile Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asp Asn Ile Ala
(SEQ ID NO: 231)
D-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys Tyr
Phe Leu Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asp Asn Ile Ala
(SEQ ID NO: 232)
D-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys Tyr
Phe Ile Glu Trp Leu Met Asn Thr Lys Arg Asn Lys Asp Asn Ile Ala
(SEQ ID NO: 233)
D-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys Tyr
Phe Ile Gln Trp Leu Lys Asn Gly Gly Pro Ser Lys Asp Asn Ile Ala
(SEQ ID NO: 234)
D-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Ile Val Lys Tyr
Phe Ile Glu Trp Leu Lys Asn Gly Gly Pro Ser Lys Asp Asn Ile Ala
(SEQ ID NO: 235)
D-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Ile Val Lys Tyr
Phe Ile Gln Trp Leu Lys Asn Gly Gly Pro Ser Lys Asp Asn Ile Ala
(SEQ ID NO: 236)
D-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Leu Val Lys Tyr
Phe Leu Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asp Asn Ile Ala
(SEQ ID NO: 237)
D-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Leu Val Lys Tyr
Phe Ile Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asp Asn Ile Ala
(SEQ ID NO: 238)
D-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Ile Val Lys Tyr
Phe Leu Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asp Asn Ile Ala
(SEQ ID NO: 239)
D-His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser Arg Arg Ala Gln Asp
Phe Val Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asp Asn Ile Ala
(SEQ ID NO: 240)
D-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser Arg Arg Ala Gln Asp
Phe Val Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asp Asn Ile Ala
(SEQ ID NO: 241)
D-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Ile Val Lys Tyr
Phe Ile Gln Trp Leu Lys Asn Gly Gly Pro Ser Lys Asp Asn Ile Ala Lys
(SEQ ID NO: 242)
D-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Ile Val Lys Tyr
Phe Ile Gln Trp Leu Lys Asn Gly Gly Pro Ser Lys Asp Asn Ile Ala Lys
(SEQ ID NO: 243)
D-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Ile Val Lys Tyr
Phe Ile Gln Trp Leu Met Asn Thr Lys Arg Asn Lys Asp Asn Ile Ala Lys
(SEQ ID NO: 244)
D-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys Tyr
Phe Ile Gln Trp Leu Lys Asn Gly Gly Pro Ser Lys Asp Asn Ile Ala Lys
(SEQ ID NO: 245)
D-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Leu Val Lys Tyr
Phe Ile Gln Trp Leu Lys Asn Gly Gly Pro Ser Lys Asp Asn Ile Ala Lys
(SEQ ID NO: 246)
D-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys Tyr
Phe Ile Gln Trp Leu Lys Asn Gly Gly Pro Ser Lys Asp Asn Ile Ala Ala Ala Lys-myristoyl
(SEQ ID NO: 247)
D-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys Tyr
Phe Ile Gln Trp Leu Lys Asn Gly Gly Pro Ser Lys Asp Asn Ile Ala Ala Ala Lys-palmitoyl
(SEQ ID NO: 248)
D-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys Tyr
Phe Ile Gln Trp Leu Lys Asn Gly Gly Pro Ser Lys Asp Asn Ile Ala Ala Ala Lys-stearoyl
(SEQ ID NO: 249)
D-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys Tyr
Phe Ile Gln Trp Leu Lys Asn Gly Gly Pro Ser Lys Asp Asn Ile Ala Ala Ala Lys-arachidoyl
(SEQ ID NO: 250)
D-His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys Tyr
Phe Leu Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asp Asn Ile Ala Glu Ala Lys
(SEQ ID NO: 251)
D-His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys Tyr
Phe Leu Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asp Asn Ile Ala Glu Ala Lys-myristoyl
(SEQ ID NO: 252)
D-His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys Tyr
Phe Leu Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asp Asn Ile Ala Glu Ala Lys-palmitoyl
(SEQ ID NO: 253)
D-His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys Tyr
Phe Leu Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asp Asn Ile Ala Glu Ala Lys-arachidoyl
(SEQ ID NO: 254)
L-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Ile Val Lys
Tyr Phe Ile Glu Trp Leu Lys Asn Gly Gly Pro Ser Lys Asp Asn Ile Ala
(SEQ ID NO: 255)
L-His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys Tyr
Phe Leu Glu Trp Leu Lys Asn Ala Gly Pro Ser Lys Asp Asn Ile Ala
(SEQ ID NO: 256)
L-His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys Tyr
Phe Leu Glu Trp Leu Lys Asn Gly Gly Pro Ser Lys Asp Asn Ile Ala
(SEQ ID NO: 257)
L-His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys Tyr
Phe Leu Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asp Asn Ile Ala
(SEQ ID NO: 258)
L-His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Ile Val Lys Tyr
Phe Ile Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asp Asn Ile Ala
(SEQ ID NO: 259)
L-His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys Tyr
Phe Leu Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asp Asn Ile Ala
(SEQ ID NO: 260)
L-His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys Tyr
Phe Ile Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asp Asn Ile Ala
(SEQ ID NO: 261)
L-His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys Tyr
Phe Ile Gln Trp Leu Met Asn Thr Lys Arg Asn Lys Asp Asn Ile Ala
(SEQ ID NO: 262)
L-His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Leu Val Lys Tyr
Phe Ile Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asp Asn Ile Ala
(SEQ ID NO: 263)
L-His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Ile Val Lys Tyr
Phe Ile Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asp Asn Ile Ala
(SEQ ID NO: 264)
L-His Ala Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys Tyr
Phe Leu Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asp Asn Ile Ala
(SEQ ID NO: 265)
L-His Ala Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys Tyr
Phe Ile Gln Trp Leu Met Asn Thr Lys Arg Asn Lys Asp Asn Ile Ala
(SEQ ID NO: 266)
L-His Ala Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Leu Val Lys Tyr
Phe Ile Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asp Asn Ile Ala
(SEQ ID NO: 267)
L-His Ala Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Ile Val Lys Tyr
Phe Leu Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asp Asn Ile Ala
(SEQ ID NO: 268)
L-His Ala Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Ile Val Lys Tyr
Phe Leu Gln Trp Leu Lys Asn Gly Gly Pro Ser Lys Asp Asn Ile Ala
(SEQ ID NO: 269)
L-His Ala Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Ile Val Lys Tyr
Phe Ile Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asp Asn Ile Ala
(SEQ ID NO: 270)
L-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys Tyr
Phe Leu Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asp Asn Ile Ala
(SEQ ID NO: 271)
L-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys Tyr
Phe Ile Glu Trp Leu Met Asn Thr Lys Arg Asn Lys Asp Asn Ile Ala
(SEQ ID NO: 272)
L-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys Tyr
Phe Ile Gln Trp Leu Lys Asn Gly Gly Pro Ser Lys Asp Asn Ile Ala
(SEQ ID NO: 273)
L-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Ile Val Lys Tyr
Phe Ile Glu Trp Leu Lys Asn Gly Gly Pro Ser Lys Asp Asn Ile Ala
(SEQ ID NO: 274)
L-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Ile Val Lys Tyr
Phe Ile Gln Trp Leu Lys Asn Gly Gly Pro Ser Lys Asp Asn Ile Ala
(SEQ ID NO: 275)
L-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Leu Val Lys Tyr
Phe Leu Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asp Asn Ile Ala
(SEQ ID NO: 276)
L-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Leu Val Lys Tyr
Phe Ile Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asp Asn Ile Ala
(SEQ ID NO: 277)
L-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Ile Val Lys Tyr
Phe Leu Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asp Asn Ile Ala
(SEQ ID NO: 278)
L-His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser Arg Arg Ala Gln Asp
Phe Val Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asp Asn Ile Ala
(SEQ ID NO: 279)
L-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser Arg Arg Ala Gln Asp
Phe Val Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asp Asn Ile Ala
(SEQ ID NO: 280)
L-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Ile Val Lys Tyr
Phe Ile Gln Trp Leu Lys Asn Gly Gly Pro Ser Lys Asp Asn Ile Ala Lys
(SEQ ID NO: 281)
L-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Ile Val Lys Tyr
Phe Ile Gln Trp Leu Lys Asn Gly Gly Pro Ser Lys Asp Asn Ile Ala Lys
(SEQ ID NO: 282)
L-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Ile Val Lys Tyr
Phe Ile Gln Trp Leu Met Asn Thr Lys Arg Asn Lys Asp Asn Ile Ala Lys
(SEQ ID NO: 283)
L-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys Tyr
Phe Ile Gln Trp Leu Lys Asn Gly Gly Pro Ser Lys Asp Asn Ile Ala Lys
(SEQ ID NO: 284)
L-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Leu Val Lys Tyr
Phe Ile Gln Trp Leu Lys Asn Gly Gly Pro Ser Lys Asp Asn Ile Ala Lys
(SEQ ID NO: 285)
L-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys Tyr
Phe Ile Gln Trp Leu Lys Asn Gly Gly Pro Ser Lys Asp Asn Ile Ala Ala Ala
Lys-myristoyl
(SEQ ID NO: 286)
L-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys Tyr
Phe Ile Gln Trp Leu Lys Asn Gly Gly Pro Ser Lys Asp Asn Ile Ala Ala Ala Lys-palmitoyl
(SEQ ID NO: 287)
L-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys Tyr
Phe Ile Gln Trp Leu Lys Asn Gly Gly Pro Ser Lys Asp Asn Ile Ala Ala Ala Lys-stearoyl
(SEQ ID NO: 288)
L-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys Tyr
Phe Ile Gln Trp Leu Lys Asn Gly Gly Pro Ser Lys Asp Asn Ile Ala Ala Ala Lys-arachidoyl
(SEQ ID NO: 289)
L-His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys Tyr
Phe Leu Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asp Asn Ile Ala Glu Ala Lys
(SEQ ID NO: 290)
L-His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys Tyr
Phe Leu Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asp Asn Ile Ala Glu Ala Lys-myristoyl
(SEQ ID NO: 291)
L-His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys Tyr
Phe Leu Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asp Asn Ile Ala Glu Ala Lys-palmitoyl
(SEQ ID NO: 292)
L-His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys Tyr
Phe Leu Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asp Asn Ile Ala Glu Ala Lys-arachidoyl
13 . A peptide according to claim 1 having a structure sequence selected from the group comprising:
(SEQ ID NO: 293)
D-His Ala Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Ile Val Lys Tyr
Phe Ile Glu Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 294)
D-His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys Tyr
Phe Leu Glu Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 295)
D-His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys Tyr
Phe Leu Glu Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 296)
D-His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Ile Val Lys Tyr
Phe Ile Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 297)
D-His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys Tyr
Phe Ile Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 298)
D-His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys Tyr
Phe Ile Gln Trp Leu Met Asn Thr Lys Arg Asn Lys Asn Asn Ile Ala
(SEQ ID NO: 299)
D-His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Leu Val Lys Tyr
Phe Ile Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 300)
D-His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Ile Val Lys Tyr
Phe Ile Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 301)
D-His Ala Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys Tyr
Phe Leu Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 302)
D-His Ala Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys Tyr
Phe Ile Gln Trp Leu Met Asn Thr Lys Arg Asn Lys Asn Asn Ile Ala
(SEQ ID NO: 303)
D-His Ala Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Leu Val Lys Tyr
Phe Ile Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 304)
D-His Ala Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Ile Val Lys Tyr
Phe Leu Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 305)
D-His Ala Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Ile Val Lys Tyr
Phe Leu Gln Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 306)
D-His Ala Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Ile Val Lys Tyr
Phe Ile Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 307)
D-His Ala Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys Tyr
Phe Ile Gln Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 308)
D-His Ala Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Leu Val Lys Tyr
Phe Leu Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 309)
D-His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser Arg Arg Ala Gln Asp
Phe Val Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 310)
D-His Ala Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser Arg Arg Ala Gln Asp
Phe Val Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 311)
D-His Ala Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Ile Val Lys Tyr
Phe Ile Gln Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala Lys
(SEQ ID NO: 312)
D-His Ala Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Ile Val Lys Tyr
Phe Ile Gln Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala Lys
(SEQ ID NO: 313)
D-His Ala Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Ile Val Lys Tyr
Phe Ile Gln Trp Leu Met Asn Thr Lys Arg Asn Lys Asn Asn Ile Ala Lys
(SEQ ID NO: 314)
D-His Ala Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys Tyr
Phe Ile Gln Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala Lys
(SEQ ID NO: 315)
D-His Ala Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Leu Val Lys Tyr
Phe Ile Gln Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala Lys
(SEQ ID NO: 316)
D-His Ala Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys Tyr
Phe Ile Gln Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala Ala Ala
Lys-myristoyl
(SEQ ID NO: 317)
D-His Ala Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys Tyr
Phe Ile Gln Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala Ala Ala Lys-palmitoyl
(SEQ ID NO: 318)
D-His Ala Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys Tyr
Phe Ile Gln Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala Ala Ala Lys-stearoyl
(SEQ ID NO: 319)
D-His Ala Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys Tyr
Phe Ile Gln Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala Ala Ala Lys-arachidoyl
(SEQ ID NO: 320)
D-His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys Tyr
Phe Leu Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala Glu Ala Lys
(SEQ ID NO: 321)
D-His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys Tyr
Phe Leu Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala Glu Ala Lys-myristoyl
(SEQ ID NO: 322)
D-His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys Tyr
Phe Leu Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala Glu Ala Lys-palmitoyl
(SEQ ID NO: 323)
D-His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys Tyr
Phe Leu Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala Glu Ala Lys-arachidoyl
(SEQ ID NO: 324)
L-His Ala Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Ile Val Lys Tyr
Phe Ile Glu Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 325)
L-His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys Tyr
Phe Leu Glu Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 326)
L-His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys Tyr
Phe Leu Glu Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 327)
L-His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Ile Val Lys Tyr
Phe Ile Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 328)
L-His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys Tyr
Phe Ile Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 329)
L-His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys Tyr
Phe Ile Gln Trp Leu Met Asn Thr Lys Arg Asn Lys Asn Asn Ile Ala
(SEQ ID NO: 330)
L-His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Leu Val Lys Tyr
Phe Ile Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 331)
L-His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Ile Val Lys Tyr
Phe Ile Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 332)
L-His Ala Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys Tyr
Phe Leu Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 333)
L-His Ala Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys Tyr
Phe Ile Gln Trp Leu Met Asn Thr Lys Arg Asn Lys Asn Asn Ile Ala
(SEQ ID NO: 334)
L-His Ala Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Leu Val Lys Tyr
Phe Ile Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 335)
L-His Ala Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Ile Val Lys Tyr
Phe Leu Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 336)
L-His Ala Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Ile Val Lys Tyr
Phe Leu Gln Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 337)
L-His Ala Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Ile Val Lys Tyr
Phe Ile Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 338)
L-His Ala Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys Tyr
Phe Ile Gln Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 339)
L-His Ala Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Leu Val Lys Tyr
Phe Leu Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 340)
L-His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser Arg Arg Ala Gln Asp
Phe Val Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 341)
L-His Ala Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser Arg Arg Ala Gln Asp
Phe Val Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 342)
L-His Ala Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Ile Val Lys Tyr
Phe Ile Gln Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala Lys
(SEQ ID NO: 343)
L-His Ala Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Ile Val Lys Tyr
Phe Ile Gln Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala Lys
(SEQ ID NO: 344)
L-His Ala Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Ile Val Lys Tyr
Phe Ile Gln Trp Leu Met Asn Thr Lys Arg Asn Lys Asn Asn Ile Ala Lys
(SEQ ID NO: 345)
L-His Ala Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys Tyr
Phe Ile Gln Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala Lys
(SEQ ID NO: 346)
L-His Ala Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Leu Val Lys Tyr
Phe Ile Gln Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala Lys
(SEQ ID NO: 347)
L-His Ala Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys Tyr
Phe Ile Gln Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala Ala Ala Lys-myristoyl
(SEQ ID NO: 348)
L-His Ala Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys Tyr
Phe Ile Gln Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala Ala Ala Lys-palmitoyl
(SEQ ID NO: 349)
L-His Ala Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys Tyr
Phe Ile Gln Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala Ala Ala Lys-stearoyl
(SEQ ID NO: 350)
L-His Ala Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys Tyr
Phe Ile Gln Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala Ala Ala Lys-arachidoyl
(SEQ ID NO: 351)
L-His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys Tyr
Phe Leu Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala Glu Ala Lys
(SEQ ID NO: 352)
L-His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys Tyr
Phe Leu Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala Glu Ala Lys-myristoyl
(SEQ ID NO: 353)
L-His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys Tyr
Phe Leu Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala Glu Ala Lys-palmitoyl
(SEQ ID NO: 354)
L-His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys Tyr
Phe Leu Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala Glu Ala Lys-arachidoyl
14 . A pharmaceutical composition comprising a peptide as claimed in claim 1 and one or more pharmaceutically acceptable carriers.
15 . (canceled)
16 . (canceled)
17 . A method of treating or preventing obesity in a subject in need thereof comprising administering to the subject a peptide according to claim 1 .
18 . A method of treating or preventing diabetes or of a co-morbidity of obesity in a subject in need thereof comprising administering to the subject a peptide according to claim 1 .
19 . A method of reducing appetite in a subject, reducing food intake in a subject or reducing calorie intake in a subject, reducing body weight in a subject, reducing body weight gain in a subject or increasing energy expenditure in a subject in need thereof comprising administering to the subject a peptide according to claim 1 .
20 . A method of causing weight loss or preventing weight gain for cosmetic purposes comprising administering to the subject a peptide according to claim 1 .
21 . A method as claimed in claim 19 , wherein the subject is overweight.
22 . A method as claimed in claim 19 , wherein the subject is obese.
23 . A method as claimed in claim 19 , wherein the subject is diabetic.
24 . The method of claim 19 , wherein the peptide is administered peripherally.
25 . The method of claim 19 , wherein the peptide is administered subcutaneously, intravenously, intramuscularly, intranasally, transdermally, transmucosally, orally, bucally, sublingually or via the lungs.Join the waitlist — get patent alerts
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