Lubricious Coating Compositions

Abstract

In one aspect, the present disclosure pertains to lubricous coating compositions that comprise (a) a higher molecular weight polyvinylpyrrolidone, (b) a lower molecular weight polyvinylpyrrolidone, and (c) a polyfunctional unsaturated crosslinking agent. In some embodiments, such lubricous coating compositions are present in crosslinked form on the surface of a medical article. In some embodiments, the lubricous coating compositions further comprise a solvent, in which case such compositions may be, for example, applied to a substrate in the form of a layer and subsequently crosslinked, thereby forming a lubricious coating on the substrate. In another aspect, the present disclosure is directed to methods for forming various medical articles.

What is claimed is: 
     
         1 . A lubricous coating composition comprising (a) a higher molecular weight polyvinylpyrrolidone, (b) a lower molecular weight polyvinylpyrrolidone, and (c) a polyfunctional unsaturated crosslinking agent. 
     
     
         2 . The lubricous coating composition of  claim 1 , wherein the higher molecular weight polyvinylpyrrolidone has a K-value ranging from 85 to 95 and wherein the lower molecular weight polyvinylpyrrolidone has a K-value ranging from 15 to 32. 
     
     
         3 . The lubricous coating composition of  claim 1 , wherein the weight ratio of higher molecular weight polyvinylpyrrolidone to lower molecular weight polyvinylpyrrolidone ranges from 70:30 to 90:10. 
     
     
         4 . The lubricous coating composition of  claim 1 , wherein the crosslinking agent is a polyfunctional ethylenically unsaturated monomer selected from a polyfunctional acrylate compound, polyfunctional methacrylate compound and a polyfunctional vinyl compound. 
     
     
         5 . The lubricous coating composition of  claim 4 , wherein the crosslinking agent is neopentyl glycol diacrylate. 
     
     
         6 . The lubricous coating composition of  claim 5 , wherein the weight ratio of total polyvinylpyrrolidone to neopentyl glycol diacrylate ranges from 0.5:1 to 4:1. 
     
     
         7 . The lubricous coating composition of  claim 1 , further comprising a solvent. 
     
     
         8 . The lubricous coating composition of  claim 7 , wherein the solvent comprises a lower alcohol and water. 
     
     
         9 . The lubricous coating composition of  claim 8 , wherein the lower alcohol is isopropanol. 
     
     
         10 . The lubricous coating composition of  claim 9 , wherein the weight ratio of water to isopropanol ranges from 50:50 to 10:90. 
     
     
         11 . The lubricous coating composition of  claim 9 , wherein the total solids ranges from 2.5 wt % to 5.5 wt %. 
     
     
         12 . The lubricous coating composition of  claim 1 , further comprising a therapeutic agent. 
     
     
         13 . The lubricous coating composition of  claim 12 , wherein the therapeutic agent is selected from antimicrobial agents, antibiotic agents, anti-cancer agents, agents for treating calcifications, antirestenotic agents, antithrombotic agents and combinations thereof 
     
     
         14 . A medical article comprising a medical article substrate that is at least partially covered by a layer of the lubricous coating composition in accordance with  claim 1 , wherein the polyfunctional unsaturated crosslinking agent is at least partially crosslinked. 
     
     
         15 . The medical article of  claim 14 , wherein the layer ranges from 0.1 to 20 micrometers in thickness. 
     
     
         16 . The medical article of  claim 14 , wherein the medical article is an implantable or insertable medical device. 
     
     
         17 . A method comprising applying the lubricous coating composition of  claim 8  to a substrate in the form of a layer, removing at least a portion of the solvent, and crosslinking the composition by applying of UV light. 
     
     
         18 . An article made by the method of  claim 17 , wherein the article is a medical article comprising a lubricious coating. 
     
     
         19 . The article of  claim 18 , wherein the medical article is an implantable or insertable medical device.