Pharmaceutical composition comprising bicyclic pyridinol derivatives for preventing or treating diseases caused by angiogenesis

Abstract

There is provided a pharmaceutical composition comprising a bicyclic pyridinol derivative as an active ingredient for preventing or treating diseases caused by angiogenesis. The bicyclic pyridinol derivative expressed by Chemical Formula 1 can be effectively used as a drug for preventing and treating diseases caused by angiogenesis since it inhibits neovascularization in a chorioallantoic membrane model.

1 . A pharmaceutical composition comprising a bicyclic pyridinol derivative expressed by the following Chemical Formula 1 for preventing or treating diseases caused by angiogenesis: 
       
         
           
           
               
               
           
         
         Wherein in the above formula, R 1  to R 3  are identical with or different from one another and are any one of hydrogen, C1 to C16 alkyl, acyloxymethyl, or trimethyltridecyl, and n is an integer of 1 to 2. 
       
     
     
         2 . The pharmaceutical composition for preventing or treating diseases caused by angiogenesis of  claim 1 , wherein in the bicyclic pyridinol derivative, R 1  is any one of hydrogen, methyl, ethyl, or n-C 16 H 33 , R 2  is any one of hydrogen or methyl, R 3  is one of hydrogen, methyl, n-butyl, t-butyl, acyloxymethyl, or trimethyltridecyl 
       
         
           
           
               
               
           
         
       
       and n is an integer of 1 to 2. 
     
     
         3 . The pharmaceutical composition for preventing or treating diseases caused by angiogenesis of  claim 1 , wherein the bicyclic pyridinol derivative is a compound expressed by the following Chemical Formula 2: 
       
         
           
           
               
               
           
         
         In the above formula, n is an integer of 1 to 2. 
       
     
     
         4 . The pharmaceutical composition for preventing or treating diseases caused by angiogenesis of  claim 1 , wherein the bicyclic pyridinol derivative is a compound expressed by the following Chemical Formula 3: 
       
         
           
           
               
               
           
         
       
     
     
         5 . The pharmaceutical composition for preventing and treating diseases caused by angiogenesis of  claim 1 , wherein the disease caused by angiogenesis is at least one selected from the group consisting of rheumatic arthritis, osteoarthritis, septic arthritis, psoriasis, corneal ulcer, senile macular degeneration, diabetic retinopathy, proliferative vitreous body retinopathy, premature retinopathy, ocular inflammation, conical cornea, Sjogren's syndrome, myopia eye tumor, cornea graft rejection, abnormal wound healing, bone disease, proteinuria, abdominal aortic aneurysm, regressive cartilage loss due to traumatic joint injury, demyelinating disease of nervous system, hepatic cirrhosis, glomerular disease, premature rupture of embryonic membrane, inflammatory bowel disease, periodontitis, atherosclerosis, restenosis, inflammatory disease of central nervous system, Alzheimer's disease, skin aging and infiltration metastasis of cancer.