Indole Derivative Modulators of the alpha 7 nAChR

Abstract

This invention relates to modulation of the α7 nicotinic acetylcholine receptor (nAChR) by a compound of formula (I) or a salt thereof: wherein R 1 is imidazolyl, pyridinyl or pyrimidinyl, any of which is optionally substituted by one group independently selected from C 1-3 alkyl and C 1-3 alkoxy.

1 . A compound of formula (I) or a salt thereof: 
       
         
           
           
               
               
           
         
       
       wherein
 R 1  is imidazolyl, pyridinyl or pyrimidinyl, any of which is optionally substituted by one group independently selected from C 1-3 alkyl and C 1-3 alkoxy. 
 
     
     
         2 . The compound or salt according to  claim 1 , wherein R 1  is imidazolyl, pyridinyl or pyrimidinyl, any of which is optionally substituted by one group independently selected from methyl and methoxy. 
     
     
         3 . The compound or salt according to  claim 1 , wherein R 1  is pyridinyl or pyrimidinyl, any of which is optionally substituted by one group independently selected from methyl and methoxy. 
     
     
         4 . The compound or salt according to  claim 1 , wherein R 1  is pyridinyl optionally substituted by one group independently selected from methyl and methoxy. 
     
     
         5 . A compound selected from:
 N-{[7-[2-(methyloxy)-3-pyridinyl]-2-(trifluoromethyl)-1H-indol-5-yl]methyl}-6-(trifluoromethyl)-3-pyridinecarboxamide;   N-{[7-(2-pyridinyl)-2-(trifluoromethyl)-1H-indol-5-yl]methyl}-6-(trifluoromethyl)-3-pyridinecarboxamide;   N-{[7-(3-pyridinyl)-2-(trifluoromethyl)-1H-indol-5-yl]methyl}-6-(trifluoromethyl)-3-pyridinecarboxamide;   N-{[7-(4-pyridinyl)-2-(trifluoromethyl)-1H-indol-5-yl]methyl}-6-(trifluoromethyl)-3-pyridinecarboxamide;   N-{[7-(5-pyrimidinyl)-2-(trifluoromethyl)-1H-indol-5-yl]methyl}-6-(trifluoromethyl)-3-pyridinecarboxamide;   N-{[7-(2-methyl-3-pyridinyl)-2-(trifluoromethyl)-1H-indol-5-yl]methyl}-6-(trifluoromethyl)-3-pyridinecarboxamide;   N-{[7-(4-methyl-3-pyridinyl)-2-(trifluoromethyl)-1H-indol-5-yl]methyl}-6-(trifluoromethyl)-3-pyridinecarboxamide;   N-{[7-[6-(methyloxy)-3-pyridinyl]-2-(trifluoromethyl)-1H-indol-5-yl]methyl}-6-(trifluoromethyl)-3-pyridinecarboxamide; and   N-{[7-(1-methyl-1H-imidazol-2-yl)-2-(trifluoromethyl)-1H-indol-5-yl]methyl}-6-(trifluoromethyl)-3-pyridinecarboxamide;   or a salt thereof.   
     
     
         6 . The salt according to  claim 1 , wherein the salt is a pharmaceutically acceptable salt. 
     
     
         7 - 16 . (canceled) 
     
     
         17 . A pharmaceutical composition comprising a) a compound or a pharmaceutically acceptable salt as described in  claim 1 , and b) one or more pharmaceutically acceptable carriers or excipients.