Ectoparasiticidal Methods and Formulations

Abstract

Provided are novel methods and formulations for topically controlling ectoparasite infestations in animals using spinetoram or a pharmaceutically acceptable salt thereof.

We claim: 
     
         1 . A method of controlling ectoparasite infestations of an animal which comprises topically administering an effective amount of spinetoram or a pharmaceutically acceptable salt thereof to said animal. 
     
     
         2 . The method of  claim 1  wherein said animal is a domestic animal. 
     
     
         3 . The method of  claim 2  wherein said domestic animal is a companion animal. 
     
     
         4 . The method of  claim 3  wherein said companion animal is a dog or cat. 
     
     
         5 . The method of  claim 1  wherein said administration is spot-on, plunge or spray dipping, jetting with a hand held spray or in a race, or as a back-line spray or pour-on. 
     
     
         6 . The method of  claim 5  wherein said administration is carried out no more than every two weeks. 
     
     
         7 . The method of  claim 6  wherein said administration is carried out no more than monthly. 
     
     
         8 . The method of  claim 1  wherein said ectoparasite is an insect. 
     
     
         9 . The method of  claim 8  where said insect is fleas. 
     
     
         10 . The method of  claim 1  wherein said effective amount is 0.01 to 1000 mg/kg of body weight of said animal. 
     
     
         11 . The method of  claim 10  wherein said effective amount is 10 to 350 mg/kg of body weight of said animal. 
     
     
         12 . A method for controlling flea infestations of a dog or cat which comprises topically administering an effective amount of spinetoram or a pharmaceutically acceptable salt thereof to said dog or cat. 
     
     
         13 . The method of  claim 12  wherein said flea is  Ctenocephalides felis . 
     
     
         14 . The method of  claim 12  wherein said administration is carried out no more than every two weeks. 
     
     
         15 . The method of  claim 14  wherein said administration is carried out no more than monthly. 
     
     
         16 . The method of  claim 12  wherein said effective amount is 10 to 350 mg/kg of body weight of said dog or cat. 
     
     
         17 . A pharmaceutical formulation for topically controlling ectoparasite infestations comprising spinetoram or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier. 
     
     
         18 . The pharmaceutical formulation of  claim 17  wherein said spinetoram or a pharmaceutically acceptable salt thereof is present in said formulation in an amount greater than 0% to 90% by weight of the formulation. 
     
     
         19 . The pharmaceutical formulation of  claim 18  wherein said spinetoram or a pharmaceutically acceptable salt thereof is present in said formulation in an amount of 1 to 45% by weight of the formulation. 
     
     
         20 . The pharmaceutical formulation of  claim 17  wherein said formulation is adapted for spot-on, plunge or spray dipping, jetting with a hand held spray or in a race, or as a back-line spray or pour-on administration. 
     
     
         21 . The pharmaceutical formulation of  claim 20  wherein said formulation is a shampoo, conditioner, or cream rinse. 
     
     
         22 . The pharmaceutical formulation of  claim 17  which is administered no more than every two weeks. 
     
     
         23 . The pharmaceutical formulation of  claim 22  which is administered no more than monthly.