Water-based Personal Moisturizers and Lubricants, in Particular Vaginal Lubricants, and Uses Thereof

Abstract

There is a need for water-based sperm- and egg-friendly vaginal lubricant. We describe novel water-based nature-friendly personal moisturizers and lubricants that relive vaginal dryness. In addition to being non-spermicidal, sperm- and egg-friendly and biological-fluids mimicking, these personal moisturizers and lubricants also enhance sperm survival and motility, promote binding of sperm to eggs and facilitate the process of fertilization. Novel articles, and systems as well as methods of preparation and use of the novel compositions are also provided.

1 .- 59 . (canceled) 
     
     
         60 . A composition comprising:
 (a) an aqueous lubricant base comprising a combination of lubricious agents in an aqueous balanced salt solution wherein the combination comprises methylparaben, glycerol, and a cellulose selected from the group consisting of methylcellulose, hydroxymethyl cellulose, hydroxyethyl cellulose, and hydroxypropylmethyl cellulose;   (b) a combination of chloride salts of calcium, sodium, potassium, and magnesium ions; and   wherein the composition excludes additional therapeutic drugs, has a pH in the range of about 5.0 to about 9.0, has an osmolality in the range of about 200 to about 700 mOsm/kg, and kills less than about 1% of the spermatozoa that are exposed to the composition.   
     
     
         61 . The composition of  claim 60 , wherein the cellulose is hydroxypropylmethyl cellulose. 
     
     
         62 . The composition of  claim 60 , wherein the pH is in the range of about 7.0 to about 8.5. 
     
     
         63 . The composition of  claim 60 , wherein the composition is devoid of EDTA. 
     
     
         64 . The composition of  claim 60 , wherein the composition is formulated as a solution, gel, foam, or cream. 
     
     
         65 . The composition of  claim 60 , wherein the osmolality of the composition is between 250 and 500 mOsm/kg. 
     
     
         66 . The composition of  claim 65 , wherein the osmolality of the composition is between about 300 and about 400 mOsm/kg. 
     
     
         67 . The composition of  claim 60 , wherein the composition is contained within a single dose container. 
     
     
         68 . A composition comprising:
 (a) an aqueous lubricant base comprising a combination of lubricious agents in an aqueous balanced salt solution wherein the combination comprises methylparaben, glycerol and one or more of: arabinogalactan, PCAGH, dextran, polyacrylic acid, carbomer, polyethylene oxide, a nonionic, surfactant polyol, methylcellulose, hydroxymethyl cellulose, hydroxyethyl cellulose, hydroxypropylmethyl cellulose, polyethylene glycol, propylene glycol, hydroxypropyl guar, or a plant oil; and   (b) a combination of chloride salts of calcium, sodium, potassium, and magnesium ions; and   wherein the composition excludes additional therapeutic drugs, has a pH in the range of about 5.0 to about 9.0, has an osmolality in the range of about 200 to about 700 mOsm/kg, and kills less than about 1% of the spermatozoa that are exposed to the composition.   
     
     
         69 . The composition of  claim 68 , wherein the cellulose is hydroxypropylmethyl cellulose. 
     
     
         70 . The composition of  claim 68 , wherein the pH is in the range of about 7.0 to about 8.5. 
     
     
         71 . The composition of  claim 68 , wherein the composition is devoid of EDTA. 
     
     
         72 . The composition of  claim 68 , wherein the composition is formulated as a solution, gel, foam, or cream. 
     
     
         73 . The composition of  claim 68 , wherein the osmolality of the composition is between about 250 and about 500 mOsm/kg. 
     
     
         74 . The composition of  claim 68 , wherein the osmolality of the composition is between about 300 and about 400 mOsm/kg. 
     
     
         75 . The composition of  claim 68  further comprising a hyaluronan. 
     
     
         76 . The composition of  claim 68 , wherein the composition is contained within a single dose container. 
     
     
         77 . A composition consisting of:
 (a) an aqueous lubricant base consisting of methylparaben, glycerol, and hydroxypropylmethyl cellulose in an aqueous balanced salt solution of dibasic sodium phosphate and monobasic sodium phosphate;   (b) a combination of salts consisting of chloride salts of calcium, sodium, potassium, and magnesium; and   wherein the composition has a pH in the range of about 5.0 to about 9.0 and an osmolality in the range of about 200 to about 700 mOsm/kg.   
     
     
         78 . The composition of  claim 77  wherein the pH is in the range of about 7.0 to about 8.5. 
     
     
         79 . The composition of  claim 77  further comprising a hyaluronan.