Antiinfective free intramammary veterinary composition

Abstract

An antiinfective-free formulation for prophylactic treatment of mastitis in dry cows comprises a seal formulation, having approximately 65% by weight of bismuth sub-nitrate in a gel based on aluminum stearate. The seal formulation is prepared by adding the bismuth sub-nitrate to the gel base in at least two separate stages.

1 - 16 . (canceled) 
     
     
         17 . A system for forming a physical barrier in a teat canal of a non-human animal, said system comprising:
 a seal formulation for infusing into the teat canal of the animal, the seal formulation being free of an agent that is anti-infective within the teat canal, the seal formulation comprising a non-toxic heavy metal compound in a gel base;   wherein the system is antibiotic-free.   
     
     
         18 . The system of  claim 17 , further comprising an injector tube for infusing the seal formulation into the teat canal of the animal. 
     
     
         19 . The system of  claim 17 , wherein the heavy metal compound comprises a heavy metal salt. 
     
     
         20 . The system of  claim 19 , wherein the seal formulation contains at least 40% by weight of the heavy metal salt. 
     
     
         21 . The system of  claim 20 , wherein the seal formulation contains from 50% to 75% by weight of the heavy metal salt. 
     
     
         22 . The system of  claim 21 , wherein the seal formulation contains approximately 65% by weight of the heavy metal salt. 
     
     
         23 . The system of  claim 19 , wherein the heavy metal salt is bismuth subnitrate. 
     
     
         24 . The system of  claim 17 , wherein the base is a gel based on aluminum stearate. 
     
     
         25 . The system of  claim 17 , wherein the base includes liquid paraffin as a vehicle. 
     
     
         26 . The system of  claim 17 , wherein the seal formulation has no bacterial action. 
     
     
         27 . A system for forming a physical barrier in a teat canal of a non-human animal and for prophylactic treatment of mammary disorders during the animal's dry period, said system comprising:
 a seal formulation that is free of an agent that is anti-infective within the teat canal of the animal and that comprises a non-toxic heavy metal compound in a gel base; and   an injector tube for infusing the seal formulation into the teat canal of the animal;   wherein the system is antibiotic-free.   
     
     
         28 . The system of  claim 27 , wherein the heavy metal compound comprises a heavy metal salt. 
     
     
         29 . The system of  claim 28 , wherein the heavy metal salt is bismuth subnitrate. 
     
     
         30 . The system of  claim 28 , wherein the seal formulation contains at least 40% by weight of the heavy metal salt. 
     
     
         31 . The system of  claim 28 , wherein the seal formulation contains from 50% to 75% by weight of the heavy metal salt. 
     
     
         32 . The system of  claim 28 , wherein the seal formulation contains approximately 65% by weight of the heavy metal salt. 
     
     
         33 . The system of  claim 27 , wherein the base is a gel based on aluminum stearate. 
     
     
         34 . The system of  claim 27 , wherein the base includes liquid paraffin as a vehicle. 
     
     
         35 . The system of  claim 27 , wherein the seal formulation has no bacterial action.