Synergistic Antimicrobial Preparations Containing Chlorite and Hydrogen Peroxide

Abstract

Antimicrobial/pharmaceutical preparations (e.g., solutions, gels, ointments, creams, sustained release preparations, etc.) which comprise chlorite (e.g., a metal salt of a chlorite) in combination with a peroxy compound (e.g., hydrogen peroxide), and methods for using such preparations for disinfection of articles or surfaces (e.g., contact lenses, counter tops, etc.), antisepsis of skin or other body parts, prevention or deterrence of scar formation and/or treatment and prophylaxis of dermal (i.e., skin or mucous membrane) disorders (e.g., wounds, burns, infections, cold sores, ulcerations, psoriasis, acne, or other scar-forming lesions).

What is claimed is: 
     
         1 . A chlorine dioxide-free preparation comprising:
 approximately 0.02-0.10 percent by weight of a chlorite compound;   approximately 0.005-0.01 percent by weight of a peroxy compound;   sodium chloride; and   water;   wherein the preparation has a pH in the range of 6.8 to 7,8; and   wherein no chlorine dioxide is generated within the solution when stored at room temperature for up to 18 months .   
     
     
         2 . A preparation according to  claim 1  wherein the chlorite is present as a metal chlorite. 
     
     
         3 . A preparation according to  claim 2  wherein the metal chlorite is selected from the group of metal chlorites consisting of:
 sodium chlorite; 
 potassium chlorite; 
 calcium chlorite; and, 
 magnesium chlorite. 
 
     
     
         4 . A preparation according to  claim 1  wherein the peroxy compound is hydrogen peroxide. 
     
     
         5 . A preparation according to  claim 1  in liquid form, said preparation comprising: 
       
         
           
                 
                 
                 
               
                     
                     
                 
                     
                   Sodium Chlorite 
                    0.02%-0.10%; 
                 
                     
                   Hydrogen Peroxide 
                   0.005%-0.01%; 
                 
                     
                   Methocel A 
                   0.05%-0.2%; 
                 
                     
                   Boric Acid 
                   0.15%; 
                 
                     
                   Sodium Chloride 
                   0.75%; 
                 
                     
                   Pluronic F-68 
                    0.1%; 
                 
                     
                   HCl or NaOH 
                   to adjust pH to about 7.4; and, 
                 
                     
                   Purified water 
                   Q.S. to volume. 
                 
                     
                     
                 
             
                
               
               
                
                
                
                
                
                
                
                
                
               
            
           
         
       
     
     
         6 . A preparation according to  claim 1  in gel form, said preparation comprising: 
       
         
           
                 
                 
                 
               
                     
                     
                 
                     
                   Sodium Chlorite 
                    0.02%-0.10% 
                 
                     
                   Hydrogen Peroxide 
                   0.005%-0.01% 
                 
                     
                   Methocel A 
                   0.05%-2.0% 
                 
                     
                   Boric Acid 
                   0.15% 
                 
                     
                   Sodium Chloride 
                   0.75% 
                 
                     
                   Pluronic F-68 
                    0.1% 
                 
                     
                   HCl or NaOH 
                   Adjust pH 7.4 
                 
                     
                   Purified water 
                   Q.S. to volume 
                 
                     
                     
                 
             
                
               
               
                
                
                
                
                
                
                
                
                
               
            
           
         
       
     
     
         7 . A preparation according to  claim 1  further comprising:
 a sustained delivery component which limits the rate at which the chlorite becomes available for generation of chlorine dioxide and hydrogen peroxide becomes available for generation of oxygen. 
 
     
     
         8 . A sustained release preparation according to  claim 7 , wherein the sustained delivery component comprises a polymer matrix. 
     
     
         9 . A sustained release preparation according to  claim 7 , wherein the sustained delivery component comprises a liposome. 
     
     
         10 . A sustained release preparation according to  claim 7 , wherein the sustained delivery component is selected from the group consisting of:
 a cellulose ester;   hydroxymethylpropyl cellulose;   methylhydroxyethyl cellulose;   hydroxypropyl cellulose;   hydroxyethyl cellulose;   carboxymethyl cellulose;   a salt of a cellulose ester;   cellulose acetate;   hydroxypropylmethyl cellulose phthalte;   methacrylic acid-methyl methacrylate copoymer;   methacrylic acid-ethyl acetate copolymer;   polyvinylpyrrolidone;   polyvinyl alcohol;   a phospholipid;   cholesterol;   a phospholipid having a neutral charge;   a phospholipid having a negative charge;   dipalmytoyl phoshatidyl choline:   dipalmytoyl phoshatidyl serine; and,   sodium salts thereof.   
     
     
         11 . A sustained release preparation according to  claim 7 , wherein the sustained delivery component comprises 1-20 percent by weight of the preparation. 
     
     
         12 . A preparation according to  claim 1  which is a liquid, 
     
     
         13 . A preparation according to  claim 1  which is a gel. 
     
     
         14 . A preparation according to  claim 1  which is a cream. 
     
     
         15 . A preparation according to  claim 1  which is an ointment. 
     
     
         16 . A preparation according to  claim 1  which is a contact lens solution, wherein said preparation further comprises at least one additional component selected from: polymeric lubricants, non-ionic polymeric lubricants, anionic polymeric lubricants; HPMC, Methocel and carboxymethylcellulose. 
     
     
         17 . A preparation according to  claim 16  wherein the surfactant comprises a block polymer based surfactant.