Method Of Treating Fragile X Syndrome And Related Disorders

Abstract

The present invention provides methods of alleviating a sign or a symptom of Fragile X Syndrome and relates disorders such as autism spectrum disorders

1 . A method of treating or alleviating a symptom of Fragile X Syndrome, comprising administering to a subject having Fragile X Syndrome a composition comprising metadoxine, wherein the symptom is impaired intellectual functioning. 
     
     
         2 . The method of  claim 1 , comprising administering a total per day dose of metadoxine of between 100-3000 mg. 
     
     
         3 . The method of  claim 1 , wherein the metadoxine is administered daily, every other day or weekly. 
     
     
         4 . The method of  claim 1 , wherein the metadoxine is administered in one, two, or three dosage forms per day. 
     
     
         5 . The method of  claim 1 , wherein the metadoxine is administered in a sustained release oral dosage form, wherein the metadoxine is formulated as a combination of slow release and immediate release forms. 
     
     
         6 . The method of  claim 5 , wherein:
 (a) the slow release form provides for sustained release of the metadoxine for at least 8 hours, and   (b) wherein relative proportion of the slow release metadoxine to the immediate release metadoxine is between about—60:40 and 80:20   
     
     
         7 . The method of  claim 6 , wherein the relative proportion of the slow release metadoxine to the immediate release metadoxine is about 65:35. 
     
     
         8 . The method of  claim 1 , wherein the impaired intellectual functioning is impaired learning. 
     
     
         9 - 10 . (canceled) 
     
     
         11 . The method of  claim 1 , wherein the method further comprises treating or alleviating impaired sociability.