Antimicrobial compounds and methods of use

Abstract

The present disclosure provides antimicrobial compounds, compositions comprising such antimicrobial compounds, and methods of their use, in particular, antibacterial compounds and antifungal compounds. In certain aspects, the antimicrobial compounds are effective against pathogens of hospital-acquired infections. In certain aspects, the antimicrobial compounds are effective against pathogens that are resistant to antibiotics. The antimicrobial compounds can be used in antibacterial compositions, antifungal compositions, antiseptic compositions and disinfectant compositions. The antimicrobial compounds can be used as adjuncts in antibacterial compositions and antifungal compositions.

1 . A compound of Formula I: 
       
         
           
           
               
               
           
         
         where n is an integer from 6-12 inclusive; R 1 , and R 2 , are the same or different and are selected independently from the group consisting of H, substituted or unsubstituted, straight or branched chain C 1 -C 10  alkyl, CH 3 , CHOHCH 3 , CH(CH 3 ) 2 , CH 2 C 6 H 6 , and CH 2 CH(CH 3 ) 2 ; R 3 , and R 4 , are the same or different and are selected independently from the group consisting of H, substituted or unsubstituted, straight or branched chain C 1 -C 10  alkyl, C 6 -C 10  aryl or C 6 -C 10  heteroaryl, CH 3 , CH(CH 3 ) 2 , CH 2 CH 2 OH, CH 2 CH(CH 3 ) 2 , and (CH 2 ) 2 N(CH 2 CH 3 ) 2 ; R 5  is methyl, and R 6  is H or CH 3 , and pharmaceutically acceptable salts thereof. 
       
     
     
         2 . A composition comprising the compound of  claim 1  and a pharmaceutically acceptable excipient. 
     
     
         3 . The composition of  claim 2  further comprising an active pharmaceutical ingredient. 
     
     
         4 . The composition of  claim 2  further comprising an additive. 
     
     
         5 . The composition of  claim 4  wherein the additive is at least one of a fragrance, an emulsifier, a stabilizer and a preservative. 
     
     
         6 . The composition of  claim 2  wherein the composition is provided in an unit dosage form. 
     
     
         7 . The composition of  claim 6  wherein the unit dosage form is a tablet, a pill, a capsule, a powder, a granule, a sterile parenteral solution or a sterile parenteral suspension, a metered aerosol spray, a metered liquid spray, a drop, an ampoule, an auto-injector device, or a suppository. 
     
     
         8 . The composition of  claim 7  formulated for inhalation, oral, parenteral, intranasal, sublingual or rectal administration.