Absorbable polyurethanes and methods of use thereof

Abstract

Disclosed are novel bioabsorbable and biodegradable monomer compounds, bioabsorbable and biodegradable polymers therefrom, and methods of making such monomers and polymers, which are useful in pharmaceutical delivery systems, tissue engineering applications, tissue adhesives products, implantable medical devices, foams and reticulated foams for wound healing and drug delivery, bone hemostats and bone void fillers, adhesion prevention barriers, meshes, filters, stents, medical device coatings, pharmaceutical drug formulations, consumer product and cosmetic and pharmaceutical packaging, apparel, infusion devices, blood collection tubes and devices, other medical tubes, skin care products, and transdermal drug delivery materials.

1 - 20 . (canceled) 
     
     
         21 . A surgical article, comprising a polymer formed from a monomer selected from the group consisting of the structures having formulas XXI-XXVIII: 
       
         
           
           
               
               
           
         
         
           
           
               
               
           
         
       
       wherein the article is selected from the group consisting of: foams, bone hemostats, bone fillers, bone substitutes, wound dressings, burn dressings, medicated dressings, adhesion prevention barriers, bone void fillers, medical device coatings, medical implantable devices, cosmetic packaging, pharmaceutical packaging, apparel, infusion devices, hernia patches, medicated dressings, fascial substitutes, gauze bandages, bandages for skin surfaces, orthopedic articles, tissue engineering scaffolds, intrauterine devices, blood collection devices, draining tubes, draining capillaries, testing tubes, testing capillaries, surgical instruments, extracorporeal tubing for kidney machines, extracorporeal tubing for heart-lung machines, and artificial skin. 
     
     
         22 . The surgical article of  claim 21 , wherein the surgical article is a medical device coating which is a stent coating. 
     
     
         23 . The surgical article of  claim 21 , wherein the surgical article is a medical implantable device selected from the group consisting of: stents, arterial grafts, arterial substitutes, anastomosis rings, prosthetic devices, clips, staples, sutures, ligatures, hooks, pins, couplings, vascular implants, vascular supports, vertebral discs, textile structures, screws, tubes, buttons, snaps, films, meshes, liver hemostasis articles, transdermal drug delivery, and controlled drug delivery systems. 
     
     
         24 . The surgical article of  claim 23 , wherein the surgical article is stent. 
     
     
         25 . The surgical article of  claim 23 , wherein the orthopedic article is selected from the group consisting of: pins, clamps, screws, and plates. 
     
     
         26 . The surgical article of  claim 23 , wherein the clip is a vena cava clip or a suture knot clip. 
     
     
         27 . The surgical article of  claim 23 , wherein the bone substitute is a mandible prosthesis. 
     
     
         28 . The surgical article of  claim 23 , wherein the controlled drug delivery system is selected from: self-supporting films, hollow tubes, beads, and gels. 
     
     
         29 . The surgical article of  claim 21 , wherein the foam is selected from the group consisting of: a reticulated foams, lyophilized foams, regular foams, foams with vertical channels, architecturally gradient foams, trans-compositional foams, and trans-structural foams. 
     
     
         30 . The surgical article of  claim 21 , wherein the intrauterine device is a spermicidal device. 
     
     
         31 . The surgical article of  claim 23 , wherein the surgical article is a controlled drug delivery system. 
     
     
         32 . The surgical article of  claim 31 , wherein the controlled drug delivery system, further comprises: one or more biologically or pharmacologically active agents physically embedded or dispersed in the controlled drug delivery system. 
     
     
         33 . The surgical article of  claim 21 , wherein the article further comprises: at least one growth promoting factor and the article is selected from the group consisting of: foams, bone hemostats, bone fillers, bone substitutes, wound dressings, burn dressings, medicated dressings, bone void fillers, and artificial skin. 
     
     
         34 . The surgical article of  claim 33 , wherein the at least one growth promoting factor is selected from: fibroblast growth factor, bone growth factor, epidermal growth factor, platelet-derived growth factor, macrophage-derived growth factor, alveolar-derived growth factor, monocyte-derived growth factor, and magainin. 
     
     
         35 . The surgical article of  claim 21 , further comprising: filler. 
     
     
         36 . The surgical article of  claim 35 , wherein the filler is selected from the group consisting of: hydroxyapatite, tricalcium phosphate, and bioglass. 
     
     
         37 . The surgical article of  claim 36 , wherein from about 10 grams to about 400 grams of the filler are mixed with about 100 grams of the polymer. 
     
     
         38 . The surgical article of  claim 21 , wherein the polymer is a polymer selected from the group consisting of polyurethanes, polyamides, polyester urethanes, and polyesteramides. 
     
     
         39 . The surgical article of  claim 38 , wherein the polymer is further polymerized on at least one end with polyesters of at least one lactone monomer selected from the group consisting of glycolide, lactide, p-dioxanone, trimethylene carbonate, and caprolactone. 
     
     
         40 . The surgical article of  claim 21 , wherein the polymer is formed from a monomer selected from the group consisting of the structures having formulas XXI-XXIV and a branched complex bearing more than 2 hydroxyl groups. 
     
     
         41 . The surgical article of  claim 40 , wherein branched complex is a triol.