Metal coordinated compositions

Abstract

A metal coordination complex of a biologically active moiety and a metal is disclosed. The complex confers to the biologically active moiety an improved performance which can include potency, stability, absorbability, targeted delivery, and combinations thereof.

1 - 47 . (canceled) 
     
     
         48 . A metal coordination complex of a biologically active moiety and a metal, wherein the biologically active moiety is selected from the group consisting of: metformin, omeprazole, famotidine, rabeprazole, theophylline, hydrochlorothiazide, alendronate, mitoxantrone, adefovir, acyclovir, clonidine, dipyramidole, atovaquone, idarubicin, etidronate, valganciclovir, saquinavir, fosamprenavir, retinoic acid, minoxidil, cyclosporine, fosphenytoin, atrial natriuretic peptide, abarelix, and heparin and their derivatives. 
     
     
         49 . The complex of  claim 48 , wherein the metal is selected from the group consisting of: aluminum, bismuth, calcium, iron, strontium, magnesium, silicon, and zinc. 
     
     
         50 . A metal coordination complex of a biologically active moiety and a metal, wherein the biologically active moiety contains a β-diketone, ketophenol or β-ketoalcohol, functional group. 
     
     
         51 . The complex of  claim 50 , wherein the metal is selected from the group consisting of: aluminum, bismuth, calcium, iron, strontium, magnesium, silicon, and zinc. 
     
     
         52 . A metal coordination complex of a biologically active moiety and a metal, wherein the biologically active moiety contains an azole functional group. 
     
     
         53 . The complex of  claim 52 , wherein the metal is selected from the group consisting of: aluminum, bismuth, calcium, iron, strontium, magnesium, silicon, and zinc. 
     
     
         54 . The complex of  claim 48 , wherein the biologically active moiety is omeprazole. 
     
     
         55 . The complex of  claim 54 , wherein the metal is selected from the group consisting of: bismuth, calcium, iron, strontium, magnesium, silicon, and zinc. 
     
     
         56 . The complex of  claim 54 , wherein the metal is selected from calcium, strontium, and magnesium. 
     
     
         57 . The complex of  claim 54 , wherein the metal is calcium. 
     
     
         58 . The complex of  claim 54 , wherein the metal is magnesium. 
     
     
         59 . The complex of  claim 54 , wherein the metal is strontium. 
     
     
         60 . A method of treating gastro esophageal reflux disease, comprising administering a complex of  claim 54  to a patient in need thereof.