US2015087819A1PendingUtilityA1

Antigen binding proteins to proprotein convertase subtilisin kexin type 9 (pcsk9)

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Assignee: AMGEN INCPriority: Aug 23, 2007Filed: Dec 5, 2014Published: Mar 26, 2015
Est. expiryAug 23, 2027(~1.1 yrs left)· nominal 20-yr term from priority
Inventors:Simon Mark JacksonNigel Pelham Clinton WalkerDerek E. PiperBei ShanWenyan ShenJoyce Chi Yee ChanChadwick Terence KingRandal R. KetchemChristopher MehlinTeresa Arazas CarabeoQiong Cao
A61P 9/00A61P 43/00A61P 9/10A61P 7/00A61P 3/06A61P 3/00A61P 25/28A61K 31/366C07K 2317/14A61K 31/66C07K 2299/00A61K 2039/505A61K 31/405A61K 31/40A61K 39/3955C07K 16/40A61K 31/505A61K 45/06C12N 15/1137C07K 2317/76C07K 2317/34A61K 31/22A61K 31/47C07K 2317/92A61K 31/44A61K 39/395A61K 2300/00C07K 2317/24
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Claims

Abstract

Antigen binding proteins that interact with Proprotein Convertase Subtilisin Kexin Type 9 (PCSK9) are described. Methods of treating hypercholesterolemia and other disorders by administering a pharmaceutically effective amount of an antigen binding protein to PCSK9 are described. Methods of detecting the amount of PCSK9 in a sample using an antigen binding protein to PCSK9 are described.

Claims

exact text as granted — not AI-modified
What is claimed is: 
     
         1 . A nucleic acid molecule comprising:
 a nucleic acid consisting of the nucleotide sequence of SEQ ID NO: 152; and   a nucleic acid consisting of the nucleotide sequence of SEQ ID NO: 153.

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