US2015094461A1PendingUtilityA1

Oligomeric compounds and compositions for use in modulation of small non-coding rnas

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Assignee: REGULUS THERAPEUTICS INCPriority: Jul 31, 2003Filed: Dec 15, 2014Published: Apr 2, 2015
Est. expiryJul 31, 2023(expired)· nominal 20-yr term from priority
Inventors:C. Frank BennettSusan M. FreierRichard H. Griffey
A61P 37/00A61P 3/00C12N 2320/30C12N 15/113C12N 2310/113C12N 2310/3515C12N 2310/317C12N 2310/31C12N 2320/50C12N 15/111C12N 2310/14C12N 2310/346C12N 2310/3341C12N 2320/11C12N 2310/321C12N 2310/3181C12N 2310/341C12N 2310/3231C12N 2310/11C12N 2310/32C12N 2310/315C12N 2310/141C12N 2310/351
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Abstract

Compounds, compositions and methods are provided for modulating the expression and function of small non-coding RNAs. The compositions comprise oligomeric compounds, targeted to small non-coding RNAs. Methods of using these compounds for modulation of small non-coding RNAs as well as downstream targets of these RNAs and for diagnosis and treatment of disease associated with small non-coding RNAs are also provided.

Claims

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What is claimed is: 
     
         1 . An oligomeric compound consisting of the nucleobase sequence of SEQ ID NO: 442, wherein the oligomeric compound consists of 2′-methoxyethoxy (2′-MOE) ribonucleotides throughout.

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