Redox signaling gel formulation

Abstract

Redox signaling gels are disclosed. Such gels include a composition with at least one reactive oxygen species (ROS) and a rheology modifier. Also presented herein is a process for making the gels which includes making the composition by taking the steps of purifying water to produce ultra-pure water, combining a salt to the ultra-pure water to create a salinated water, electrolyzing the salinated water at a temperature of 4.3 to 5.8° C. such that the electrolyzing is accomplished with an anode, cathode and power source such that the power source comprises a transformer and a rectifier and does not comprise a filter capacitor.

I claim: 
     
         1 . A gel formulation comprising;
 a. a composition comprising at least one reactive oxygen species (ROS), and   b. a rheology modifier;   wherein the process of making the composition comprises the steps of purifying water to produce ultra-pure water, combining a salt to the ultra-pure water to create a salinated water, electrolyzing the salinated water at a temperature of from 4.3 to 5.8° C. wherein the electrolyzing is accomplished with an anode, cathode and power source such that a) the power source comprises a transformer and a rectifier and does not comprise a filter capacitor and b) no membrane is used between the anode and cathode during the process of electrolyzing.   
     
     
         2 . The formulation of  claim 1 , wherein the at least one reactive oxygen species (ROS) is a superoxide. 
     
     
         3 . The formulation of  claim 1 , wherein the at least one reactive oxygen species (ROS) is hypochlorous acid or a salt thereof. 
     
     
         4 . The formulation of  claim 1 , wherein the at least one reactive oxygen species (ROS) is present at an amount of at least 25% of its original concentration after 1 year. 
     
     
         5 . The formulation of  claim 1 , wherein the process is a scaled up process. 
     
     
         6 . The formulation of  claim 1 , wherein the salt is sodium chloride. 
     
     
         7 . The formulation of  claim 1 , wherein the process includes a pulsating voltage such that the voltage is 0 at least 30 times per second and the voltage remains positive at all times. 
     
     
         8 . The formulation of  claim 1 , wherein the gel has a pH between 6 and 9. 
     
     
         9 . The formulation of  claim 1 , wherein the composition comprises:
 a. sodium present at a concentration of 1000 to 1400 ppm wherein the sodium is measured by inductively coupled plasma mass spectrometry (ICP-MS),   b. chloride present at a concentration from 1200 to 1600 ppm as wherein the chloride is measured by inductively coupled plasma mass spectrometry (ICP-MS) or chloride is present at a concentration from 0 to 1 ppm wherein the chloride is measured by  35 Cl nuclear magnetic resonance ( 35 Cl NMR),   c. hypochlorous acid present at a concentration of 16 to 24 ppm wherein the hypochlorous acid is measured by colorimetry or hypochlorous acid present at a concentration of 2300 to 2700 ppm wherein the hypochlorous acid is measured by  25 Cl nuclear magnetic resonance ( 25 Cl NMR),   d. superoxide radical present at a concentration of 94 uM wherein the superoxide radical is measured by 5-(Diisopropoxyphosphoryl)-5-1-pyrroline-N-oxide nuclear magnetic resonance (DIPPMPO-NMR) or no superoxide radical, and   e. hydroxyl radical present at a concentration of 241 uM wherein the hydroxyl xeradical is measured by DIPPMPO-NMR or hydroxyl radical present at a concentration of 0 to 10 ppm wherein the hydroxyl radical is measured by mass spectrometry (MS) or no hydroxyl radical.   
     
     
         10 . The formulation of  claim 9 , wherein the sodium, chloride, hypochlorous acid, superoxide radical and hydroxyl radical are measured less than one year after the composition was made. 
     
     
         11 . The formulation of  claim 9 , wherein the sodium, chloride, hypochlorous acid, superoxide radical and hydroxyl radical are present at any time within 1 year after the composition was made. 
     
     
         12 . The formulation of  claim 9 , wherein the sodium, chloride, hypochlorous acid, superoxide and hydroxyl radical are measured at different times. 
     
     
         13 . The formulation of  claim 9 , wherein the sodium, chloride, hypochlorous acid, superoxide radical and hydroxyl radical are measured at the same time. 
     
     
         14 . The formulation of  claim 1 , wherein the rheology modifier comprises SiO 2 , MgO, Li 2 O, and Na 2 O. 
     
     
         15 . The formulation of  claim 1 , wherein the rheology modifier comprises a crosslinked acrylic acid polymer. 
     
     
         16 . The formulation of  claim 1 , wherein the composition has an electron paramagnetic resonance (EPR) spectrum as shown in  FIG. 13 .