US2015105516A1PendingUtilityA1

Method for the preparation of high molecular weight oligo(alkylene glycol) functionalized polyisocyanopeptides

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Assignee: STICHTING KATHOLIEKE UNIVPriority: Jul 16, 2009Filed: Dec 19, 2014Published: Apr 16, 2015
Est. expiryJul 16, 2029(~3 yrs left)· nominal 20-yr term from priority
Inventors:Alan Edward RowanRoeland Johannes Maria NolteJeroen Johannes Lambertus Maria CornelissenHeather Joy KittoErik SchwartzMatthieu Koepf
C09D 177/04C08G 65/33348C08L 77/04C08L 2201/54C08G 69/40
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Claims

Abstract

The present invention relates to a process for the preparation of oligo(alkylene glycol)-functionalized polyisocyanopeptides comprising the steps of functionalizing an isocyanopeptide with oligo-(alkylene glycol) side chains and subsequently polymerizing the oligo-alkylene glycol-functionalized isocyanopeptides. Several isocyanopeptides may be functionalized with various linear or non-linear oligo-(alkylene glycol) side chains having variable chain length. The alkylene glycol may be selected from the group consisting of ethylene-, propylene-, butylene- or pentylene glycol. Preferably, the isocyanopeptides are functionalized with at least three ethylene glycol side chains. The peptides may comprise L-amino acids, D-amino acids or D, L-amino acids. The obtained oligoalkylene-functionalized polyisocyanopeptides are a new class of materials with unique thermo-responsive properties.

Claims

exact text as granted — not AI-modified
1 .- 13 . (canceled) 
     
     
         14 . A poly[oligo(alkylene glycol)]isocyanopeptide having a degree of polymerization of more than 1500. 
     
     
         15 . The poly[oligo(alkylene glycol)]isocyanopeptide of  claim 14 , wherein the isocyanopeptide is an isocyanodipeptide. 
     
     
         16 . The poly[oligo(alkylene glycol)]isocyanopeptide of  claim 14 , wherein several isocyanopeptides are functionalized with different oligo-(alkylene glycol) side chains having a variable chain length. 
     
     
         17 . The poly[oligo(alkylene glycol)]isocyanopeptide of  claim 14 , wherein the alkylene glycol is selected from the group consisting of ethylene-, propylene-, butylene- or pentylene glycol. 
     
     
         18 . The poly[oligo(alkylene glycol)]isocyanopeptide of  claim 17 , wherein the alkylene glycol is ethylene glycol. 
     
     
         19 . The poly[oligo(alkylene glycol)]isocyanopeptide of  claim 19 , wherein the isocyanopeptide is functionalized with at least three ethylene glycol side chains. 
     
     
         20 . The poly[oligo(alkylene glycol)]isocyanopeptide of  claim 14 , wherein the isocyanopeptide monomer comprises D-, L- or D- and L-amino acids. 
     
     
         21 . A hydrogel comprising the poly[oligo(alkylene glycol)]isocyanopeptide of  claim 14 . 
     
     
         22 . A coating comprising the poly[oligo(alkylene glycol)]isocyanopeptide of  claim 14 .

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