Filamentary devices for treatment of vascular defects

Abstract

Devices and methods for treatment of a patient's vasculature with some embodiments configured for delivery with a microcatheter for treatment of the cerebral vasculature of a patient. Some embodiments may include a permeable shell configured to occlude blood flow therethrough.

What is claimed is: 
     
         1 . A device comprising:
 a resilient permeable body having a proximal end, a distal end, a longitudinal axis and a plurality of elongate resilient filaments with a woven structure secured relative to each other at proximal ends and distal ends thereof, the filaments including at least plural first filaments interwoven with at least plural second filaments, the first filaments having a first diameter and the second filaments having a second diameter, the second diameter being different from the first diameter, the body being deformable into a radially constrained elongated state configured for delivery within a catheter with the first and second filaments extending longitudinally from the proximal end to the distal end, the body being biased to an expanded relaxed state with a longitudinally shortened configuration relative to the radially constrained state with the filaments forming a smooth path radially expanded from the longitudinal axis between the proximal end and distal end and including a plurality of openings formed between the filaments; and   a proximal hub assembly connected to at least some of the filaments and connectable to a tether and including:   a hub cavity for mechanically capturing a knot associated with the tether, the hub cavity being established by a proximal shoulder portion of the proximal hub assembly, the proximal shoulder portion including an opening through which the tether can extend but through which opening the knot cannot pass.   
     
     
         2 . The device of  claim 1 , wherein the distal and proximal ends of the body are everted to form respective concave distal and proximal body cavities, the body cavities defining respective distal and proximal peripheries, the proximal hub assembly being disposed in the proximal body cavity and a distal hub being disposed in the distal body cavity, proximal and distal segments, respectively, of the filaments being engaged with the proximal and distal hubs, wherein
 the distal hub defines a distal end and the distal end of the distal hub is recessed proximally from the distal periphery; and   the proximal hub assembly defines a proximal end and the proximal hub assembly is recessed in the proximal cavity with the proximal end extending proximally past the proximal periphery.   
     
     
         3 . The device of  claim 1 , wherein the knot is secured by bonding to a distal end of the tether within the cavity. 
     
     
         4 . The device of  claim 1 , wherein the knot is secured by potting to a distal end of the tether within the cavity. 
     
     
         5 . The device of  claim 1 , wherein the knot is secured by bonding to proximal ends of the filaments. 
     
     
         6 . The device of  claim 1 , wherein the knot is secured by potting to proximal ends of the filaments. 
     
     
         7 . The device of  claim 1 , wherein the knot is secured to proximal ends of the filaments by mechanical compression. 
     
     
         8 . The device of  claim 1 , wherein the knot is secured to proximal ends of the filaments by adhesive bonding. 
     
     
         9 . The device of  claim 1 , wherein the knot is secured to proximal ends of the filaments by welding. 
     
     
         10 . The device of  claim 1 , wherein the knot is secured to proximal ends of the filaments by soldering material. 
     
     
         11 . The device of  claim 1 , wherein the knot is secured to proximal ends of the filaments by brazing material. 
     
     
         12 . The device of  claim 1 , comprising the tether, wherein the tether is dissolvable. 
     
     
         13 . The device of  claim 1 , comprising the tether, wherein the tether is severable. 
     
     
         14 . The device of  claim 1 , comprising the tether, wherein the tether is releasable by passing electrical current through at least a portion of the tether. 
     
     
         15 . The device of  claim 1 , comprising the tether and a heater coil surrounding a distal segment of the tether, wherein the tether is releasable by passing electrical current through at least the heater coil. 
     
     
         16 . A device for treating an aneurysm comprising:
 a resilient body made of plural filaments extending between a distal end and a proximal end of the body and defining an axis between the distal end and proximal end;   the body being deformable to a placement configuration for engaging the body with an aneurysm, the body being materially biased to an enlarged configuration in which the body presents a curvilinear path to tissue abutting the body;   the distal and proximal ends being everted to form respective concave distal and proximal cavities, the cavities defining respective distal and proximal peripheries, a proximal hub assembly being disposed in the proximal cavity and a distal hub being disposed in the distal cavity, proximal and distal segments, respectively, of the filaments being engaged with the proximal and distal hubs, wherein   the distal hub is recessed in the distal cavity; and   the proximal hub assembly is recessed in the proximal cavity.   
     
     
         17 . The device of  claim 16 , wherein at least some of the filaments are made of superelastic alloy material. 
     
     
         18 . The device of  claim 16 , comprising a flaccid tether attached to the proximal hub assembly. 
     
     
         19 . The device of  claim 16 , wherein the distal hub is radiopaque. 
     
     
         20 . The device of  claim 16 , wherein in the enlarged configuration the body includes straight sides extending between the distal and proximal ends. 
     
     
         21 . The device of  claim 16 , wherein in the enlarged configuration the body includes arcuate sides extending between the distal and proximal ends. 
     
     
         22 . The device of  claim 16 , wherein the proximal hub assembly is connectable to a tether and the proximal hub assembly includes:
 a cavity for mechanically capturing a knot associated with the tether, the cavity being established by a proximal shoulder portion of the proximal hub assembly, the proximal shoulder portion including an opening through which the tether can extend but the knot cannot pass through.   
     
     
         23 . The device of  claim 22 , wherein the knot is secured by bonding to a distal end of the tether within the cavity. 
     
     
         24 . The device of  claim 22 , wherein the knot is secured by potting to a distal end of the tether within the cavity. 
     
     
         25 . The device of  claim 22 , wherein the knot is secured by bonding to proximal ends of the filaments. 
     
     
         26 . The device of  claim 22 , wherein the knot is secured by potting to proximal ends of the filaments. 
     
     
         27 . The device of  claim 22 , wherein the knot is secured to proximal ends of the filaments by mechanical compression. 
     
     
         28 . The device of  claim 22 , wherein the knot is secured to proximal ends of the filaments by adhesive bonding. 
     
     
         29 . The device of  claim 22 , wherein the knot is secured to proximal ends of the filaments by welding. 
     
     
         30 . The device of  claim 22 , wherein the knot is secured to proximal ends of the filaments by soldering material. 
     
     
         31 . The device of  claim 16 , the filaments including at least plural first filaments interwoven with at least plural second filaments, the first filaments having a first diameter and the second filaments having a second diameter. 
     
     
         32 . The device of  claim 18 , comprising the tether, wherein the tether is dissolvable. 
     
     
         33 . The device of  claim 18 , comprising the tether, wherein the tether is severable. 
     
     
         34 . The device of  claim 18 , comprising the tether, wherein the tether is releasable by passing electrical current through at least a portion of the tether. 
     
     
         35 . The device of  claim 16 , wherein the distal hub defines a distal end and the distal end of the distal hub is recessed proximally from the distal periphery, and the proximal hub assembly defines a proximal end and the proximal end of the proximal hub assembly is recessed distally from the proximal periphery. 
     
     
         36 . The device of  claim 18 , comprising the tether and a heater coil surrounding a distal segment of the tether, wherein the tether is releasable by passing electrical current through at least the heater coil. 
     
     
         37 . A device comprising:
 a resilient body composed of a plurality of elongate resilient filaments secured relative to each other at proximal ends and distal ends thereof, the filaments including at least plural first filaments interwoven with at least plural second filaments, the first filaments having a first diameter and the second filaments having a second diameter, the second diameter being different from the first diameter, the body being deformable into a radially constrained elongated state configured for delivery within a catheter with the first and second filaments extending longitudinally, the body being biased to an expanded relaxed state with a longitudinally shortened configuration relative to the radially constrained state with the filaments forming a smooth path radially expanded from the longitudinal axis between the proximal ends and distal ends and including a plurality of openings formed between the filaments; and   a proximal hub assembly engaged with at least some of the proximal ends of the filaments and connected to a tether, a heater coil surrounding a distal segment of the tether to rupture the tether when electricity is applied to the heater coil.   
     
     
         38 . The device of  claim 1 , wherein the body includes plural platinum filaments including platinum and plural nitinol-only filaments including only nitinol. 
     
     
         39 . The device of  claim 16 , wherein the body includes plural platinum filaments including platinum and plural nitinol-only filaments including only nitinol.