US2015110769A1PendingUtilityA1

Method for retarding unhealthy manifestations brought by ageing of human beings

Assignee: CLS THERAPEUTICS LTDPriority: Apr 25, 2005Filed: Dec 22, 2014Published: Apr 23, 2015

Est. expiryApr 25, 2025(expired)· nominal 20-yr term from priority

Inventors:Dmitry Dmitrievich Genkin Viktor Veniaminovich Tets Georgy Viktorovich Tets

A61P 43/00C12Y 301/21001A61K 38/00A61P 15/00C07K 16/44C12N 9/22

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Abstract

The present invention provides a method for retarding unhealthy manifestations brought by ageing of human beings (in particular, but not limited to the reduction of sexual activity and fertility, climax, changes in glucose tolerance, reduction of cognitive and mnestic functions, reduction of stress resistance, development of organ and tissue sclerosis). According to the invention this task is solved by administration into the blood circulation of an agent which inactivates extracellular blood plasma DNA e.g. a DNase enzyme.

Claims

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1 - 7 . (canceled) 
     
     
         8 . A method for increasing longevity of a human subject in need thereof, said method comprising administering to said subject a DNase enzyme in a dose and regimen which is sufficient to decrease the average molecular weight of extracellular blood DNA in the blood of said subject. 
     
     
         9 . The method of  claim 8 , wherein DNase is administered orally. 
     
     
         10 . The method of  claim 8 , wherein DNase is administered intravenously. 
     
     
         11 . The method of  claim 8 , wherein DNase is administered intramuscularly.

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