Stimuli responsive polyester amide particles

Abstract

A composition including a solution suitable for introduction into a blood vessel comprising particles including a treatment agent and a tunable stimuli-responsive polymer. A method including introducing a delivery device into a blood vessel; and introducing a solution into the blood vessel, the solution including particles comprising a treatment agent and a tunable stimuli-responsive polymer. A method including combining a treatment agent and a tunable stimuli-responsive polymer; and forming particles of the combination suitable for delivery through a blood vessel.

What is claimed is: 
     
         1 . A method comprising:
 introducing a solution through a delivery device into a blood vessel, wherein the solution comprises particles comprising a treatment agent and a tunable stimuli-responsive polymer.   
     
     
         2 . The method of  claim 1  wherein the stimuli-responsive polymer comprises a polymer responsive to at least one of a physiochemical and a pharmacochemical stimulus. 
     
     
         3 . The method of  claim 1  wherein the polymer comprises an amino acid backbone. 
     
     
         4 . The method of  claim 3  wherein the polymer comprises a polyester amide. 
     
     
         5 . The method of  claim 3  wherein the polymer comprises a backbone comprising an amino acid, a diol, and a diacid. 
     
     
         6 . The method of  claim 3  wherein the treatment agent comprises one of an anti-inflammatory agent and an anti-proliferative agent. 
     
     
         7 . The method of  claim 1  wherein the delivery device comprises a percutaneously inserted transluminal catheter and introducing a solution through the delivery device comprises introducing the catheter to a treatment site. 
     
     
         8 . A method comprising:
 combining a treatment agent and a tunable stimuli-responsive polymer; and   forming particles of the combination suitable for delivery through a blood vessel.   
     
     
         9 . The method of  claim 8 , wherein the particles comprise nanoparticles. 
     
     
         10 . The method of  claim 9  wherein the polymer comprises a polyester amide. 
     
     
         11 . The method of  claim 8  wherein combining comprises conjugating the treatment agent to the polymer. 
     
     
         12 . The method of  claim 8  wherein the particles comprise a treatment agent with multiple layers of the polymer. 
     
     
         13 . The method of  claim 8  wherein the polymer further comprises a hydrophilic diamine or diol conjugated to the polymer. 
     
     
         14 . A composition comprising:
 a solution suitable for introduction into a blood vessel having particles comprising a treatment agent and a stimuli-responsive polymer, the stimuli-responsive polymer having a backbone comprising an amino acid, a diol and a diacid and wherein a hydrophilic diamine or diol is conjugated to the polymer.   
     
     
         15 . The composition of  claim 14  wherein the amino acid is a first amino acid, the composition further comprising:
 a second amino acid. 
 
     
     
         16 . The composition of  claim 15  wherein the first amino acid is lysine and the second amino acid is cysteine. 
     
     
         17 . The composition of  claim 14  wherein the treatment agent is conjugated to the backbone.