Hemostatic sponge

Abstract

The present invention provides a hemostatic porous sponge comprising a matrix of a fibrous biomaterial and particles of a fluid absorbing, particulate material adhered to said matrix material, a method of producing these sponges and their use for wound healing.

1 . A hemostatic porous sponge comprising a matrix of a fibrous biomaterial and particles of a fluid absorbing particulate material adhered to said matrix material. 
     
     
         2 . The sponge according to  claim 1 , wherein said fibrous biomaterial comprises collagen. 
     
     
         3 . The sponge according to  claim 1 , wherein said particulate material is a hemostatic material. 
     
     
         4 . The sponge according to  claim 3 , wherein said particulate material is a cross-linked polymer. 
     
     
         5 . The sponge according to  claim 3 , wherein said particulate material comprises gelatin, fibrin, collagen or any mixture thereof. 
     
     
         6 . The sponge according to  claim 1  further comprising thrombin or a precursor of thrombin. 
     
     
         7 . The sponge according to  claim 1  further comprising an adhesive layer. 
     
     
         8 . The sponge according to  claim 7 , wherein said adhesive layer comprises a bioresorbable polymer. 
     
     
         9 . The sponge according to  claim 7 , wherein the adhesive comprises a first cross-linkable component, a second cross-linkable component that cross-links with the first cross-linkable component under reaction enabling conditions. 
     
     
         10 . The sponge according to  claim 9 , wherein said first and/or second cross-linkable component comprise PEG or a derivative thereof. 
     
     
         11 . The sponge according to  claim 7 , wherein said adhesive comprises succinimidyl or maleimidyl and thiol or amino groups. 
     
     
         12 . The sponge according to  claim 7 , wherein said adhesive layer is discontinuously coated on at least one side of the sponge. 
     
     
         13 . The sponge according to  claim 1  being freeze-dried or air-dried. 
     
     
         14 . The sponge according to  claim 1  comprising a supporting layer with greater tensile strength than the matrix material. 
     
     
         15 . The sponge according to  claim 14 , wherein said supporting layer comprises a bioresorbable polymer. 
     
     
         16 . The sponge according to  claim 14 , wherein said supporting layer comprises has a greater density than the matrix material. 
     
     
         17 . A method of manufacturing a hemostatic porous sponge comprising providing a fluid of a fibrous biomaterial and suspended particles of a fluid absorbing, particulate material, and drying said fluid with the suspended particles, thereby obtaining a hemostatic porous sponge comprising a matrix of a fibrous biomaterial and particles of a fluid absorbing, particulate material adhered to said matrix material. 
     
     
         18 . A hemostatic porous sponge obtainable by a method according to  claim 17 . 
     
     
         19 . Method of treating an injury comprising administering a hemostatic porous sponge comprising a matrix of a fibrous biomaterial and a fluid absorbing, particulate material adhered to said matrix material to the site of injury. 
     
     
         20 . The method according to  claim 19 , wherein said injury comprises a wound, a hemorrhage, damaged tissue and/or bleeding tissue.