Coumarin-based compounds for the treatment of alzheimer's disease and cancer

Abstract

Compounds including those of the Formula I where X, R 1 , R 2 and subscript t are as defined herein, useful as γ-secretase inhibitors, are provided, as are compositions comprising the compounds, as well as methods for use of the compounds for treating or preventing neurodegenerative diseases, such as, for instance, Alzheimer's disease.

1 - 164 . (canceled) 
     
     
         165 . A compound according to Formula I 
       
         
           
           
               
               
           
         
       
       or a pharmaceutically acceptable salt thereof, wherein
 each X is O; 
 each R 1  is independently halo, C 1 -C 8  alkoxy, cyano, amino, hydroxy, or C 2 -C 8  alkyl; 
 R 2  is C 1 -C 8  alkylene or C 2 -C 8  alkenylene; and 
 t is an integer from 2 to 5. 
 
     
     
         166 . The compound of  claim 165 , wherein the compound has the structure: 
       
         
           
           
               
               
           
         
       
       or a pharmaceutically acceptable salt thereof. 
     
     
         167 . A composition comprising an effective amount of the compound or pharmaceutically acceptable salt of the compound of  claim 165  and a pharmaceutically acceptable carrier or vehicle. 
     
     
         168 . A composition comprising an effective amount of the compound or pharmaceutically acceptable salt of the compound of  claim 166 , and a pharmaceutically acceptable carrier or vehicle. 
     
     
         169 . A method for treating or preventing a neurodegenerative disease, comprising administering to a subject in need thereof an effective amount of the compound or pharmaceutically acceptable salt of the compound of  claim 165 . 
     
     
         170 . A method for treating or preventing a neurodegenerative disease, comprising administering to a subject in need thereof an effective amount of the compound or pharmaceutically acceptable salt of the compound of  claim 166 . 
     
     
         171 . The method of  claim 169 , wherein the neurodegenerative disease is Alzheimer's disease. 
     
     
         172 . The method of  claim 170 , wherein the neurodegenerative disease is Alzheimer's disease. 
     
     
         173 . A method for treating or preventing cancer, comprising administering to a subject in need thereof an effective amount of the compound or pharmaceutically acceptable salt of the compound of  claim 165 . 
     
     
         174 . A method for treating or preventing cancer, comprising administering to a subject in need thereof an effective amount of the compound or pharmaceutically acceptable salt of the compound of  claim 166 .