Treatment of neurological disorders

Abstract

A treatment of a neurological disorder, including hypoxia, oxygen-glucose deprivation and acute brain trauma in a subject involves administering an effective amount of selenate or a pharmaceutically acceptable salt thereof to the subject. The treatment prevents incurring a symptom, holds in check a symptom or treats an existing symptom of the neurological disorder.

What is claimed is: 
     
         1 . A method for the treatment of a neurological disorder selected from the group consisting of hypoxia, oxygen-glucose deprivation and acute brain trauma in a subject comprising administering an effective amount of selenate or a pharmaceutically acceptable salt thereof, wherein the treatment prevents incurring a symptom, holds in check a symptom or treats an existing symptom of said neurological disorder. 
     
     
         2 . The method according to  claim 1  wherein the effective amount of selenate or a pharmaceutically acceptable salt thereof delivers a supranutritional amount of selenium. 
     
     
         3 . The method according to  claim 2  wherein the supranutritional amount of selenium is 5 μg/kg to 1.0 mg/kg per day. 
     
     
         4 . The method according to  claim 1  wherein the selenate is in the form of sodium selenate. 
     
     
         5 . The method according to  claim 1  further comprising administration of the selenate or pharmaceutically acceptable salt thereof is in combination with another therapy for the treatment or prevention of neurological disorders selected from hypoxia, oxygen-glucose deprivation and acute brain trauma. 
     
     
         6 . A method according to  claim 1  wherein the symptoms of stroke are caused by ischaemia. 
     
     
         7 . A method according to  claim 6  wherein the acute brain trauma is traumatic brain injury. 
     
     
         8 . A method according to  claim 2  wherein the supranutritional amount of selenium is 0.05 mg/kg to 1 mg/kg per day.