Inhibition of tnf-alpha induced activation of nfkb by pentosan polysulfate

Abstract

Oral pentosan polysulfate (PPS) compositions treat diseases such as diabetes, inflammation, atherosclerosis. The compositions are also effective in reducing matrix metalloproteinases (MMPs).

1 . A method of preventing or treating a disease or disorder associated with tumor necrosis factor-α (TNFα) induction of nuclear factor-KB (NF-κB) activation selected from the group consisting of chronic and acute inflammation diabetic nephropathy, atherosclerosis, prostatic diseases or disorders, cardiovascular diseases or disorders, obesity, diabetes or combinations thereof comprising:
 administering to a patient in need thereof, a therapeutically effective dose of pentosan polysulfate (PPS). 
 
     
     
         2 . The method of  claim 1 , wherein the pentosan polysulfate (PPS) is administered as an oral formulation. 
     
     
         3 . The method of  claim 1 , wherein the pentosan polysulfate is administered at least once to the patient at fixed, escalating, decreasing doses or combinations thereof. 
     
     
         4 . (canceled) 
     
     
         5 . A method of preventing or treating atherosclerosis in a patient comprising:
 administering to a patient in need thereof, a therapeutically effective dose of pentosan polysulfate (PPS); and,   preventing or treating atherosclerosis in a patient.   
     
     
         6 . The method of  claim 5 , which comprises administering the pentosan polysulfate (PPS) is administered as an oral formulation. 
     
     
         7 . The method of  claim 5 , which comprises administering the pentosan polysulfate at least once to a patient at fixed, escalating, decreasing doses or combinations thereof. 
     
     
         8 . The method of  claim 5 , wherein the pentosan polysulfate decreases atherosclerotic lesions in a patient. 
     
     
         9 . The method of  claim 5 , wherein the pentosan polysulfate inhibits monocytic infiltration into atherosclerotic plaques. 
     
     
         10 - 13 . (canceled) 
     
     
         14 . A method of treating acute or chronic inflammatory disease in a patient, comprising:
 administering to a patient in need thereof, a therapeutically effective dose of pentosan polysulfate (PPS); and,   treating acute or chronic inflammatory disease in a patient.   
     
     
         15 . The method of  claim 14 , which comprises administering the pentosan polysulfate (PPS) to the patient orally. 
     
     
         16 . The method of  claim 14 , which comprises administering the pentosan polysulfate at least once to the patient at fixed, escalating, decreasing doses or combinations thereof. 
     
     
         17 . The method of  claim 14 , wherein the acute or chronic inflammatory disease comprises: asthma, cancer, atherosclerosis, ischaemic heart disease, autoimmune diseases, chronic inflammation, chronic prostatitis, glomerulonephritis, hypersensitivities, inflammatory bowel diseases, pelvic inflammatory disease, reperfusion injury, rheumatoid arthritis, transplant rejection, vasculitis or combinations thereof. 
     
     
         18 - 23 . (canceled)