Topical formulations and uses thereof

Abstract

Provided herein include formulations for topical administration, such as ophthalmic formulations, and methods of using such formulations. In some aspects and embodiments the formulations may include a polyoxyl lipid or fatty acid, and or a polyalkoxylated alcohol and may include nanomicelles. Also include methods of treating or preventing diseases or conditions, such as ocular diseases or conditions.

What is claimed is: 
     
         1 . An ophthalmic formulation, comprising cyclosporine, a polyoxyl lipid or fatty acid and a polyalkoxylated alcohol. 
     
     
         2 . The ophthalmic formulation of  claim 1 , wherein said polyoxly lipid comprises one or more selected from the group consisting of HCO-40, HCO-60, HCO-80, HCO-100, polyoxyl 40 stearate and polyoxyl 35 castor oil. 
     
     
         3 . The ophthalmic formulation of  claim 1 , wherein said polyoxly lipid comprises one or more selected from the group consisting of HCO-40, HCO-60 and HCO-80. 
     
     
         4 . The ophthalmic formulation of  claim 1 , wherein said polyoxly lipid comprises HCO-40. 
     
     
         5 . The ophthalmic formulation of  claim 1 , wherein said polyoxly lipid comprises one or more selected from the group consisting of HCO-60, HCO-80, HCO-100, polyoxyl 40 stearate and polyoxyl 35 castor oil and is present in an amount between 0.05-5% of the formulation. 
     
     
         6 . The ophthalmic formulation of  claim 1 , wherein said polyoxly lipid comprises one or more selected from the group consisting of HCO-40, HCO-60, HCO-80, HCO-100, polyoxyl 40 stearate and polyoxyl 35 castor oil and is present in an amount between 0.5-1.5% of the formulation. 
     
     
         7 . The ophthalmic formulation of  claim 1 , wherein said polyoxly lipid comprises one or more selected from the group consisting of HCO-40 HCO-60, and HCO-80, and is present in an amount between 0.5-1.5% of the formulation. 
     
     
         8 . The ophthalmic formulation of  claim 1 , wherein said polyalkoxylated alcohol is Octoxynol-40. 
     
     
         9 . The ophthalmic formulation of  claim 1 , wherein the polyalkoxylated alcohol is Octoxynol-40 and is present in an amount between 0.02 and 4% of the formulation. 
     
     
         10 . The ophthalmic formulation of  claim 1 , wherein the polyalkoxylated alcohol is Octoxynol-40 and is present in an amount between 0.02 and 0.1% of the formulation. 
     
     
         11 . The ophthalmic formulation of  claim 1 , wherein the cyclosporine is present in an amount between 0.05 and 5% of the formulation. 
     
     
         12 . The ophthalmic formulation of  claim 1 , wherein the cyclosporine is present in an amount between 0.05 and 0.2% of the formulation. 
     
     
         13 . The ophthalmic formulation of  claim 1 , wherein said polyoxly lipid comprises one or more selected from the group consisting of HCO-40, HCO-60, HCO-80, HCO-100, polyoxyl 40 stearate and polyoxyl 35 castor oil; and wherein said polyalkoxylated alcohol is Octoxynol-40. 
     
     
         14 . The ophthalmic formulation of  claim 1 , wherein said polyoxly lipid comprises one or more selected from the group consisting of HCO-40, HCO-60, HCO-80, HCO-100, polyoxyl 40 stearate and polyoxyl 35 castor oil and is present in an amount between 0.5-5% of the formulation; and said polyalkoxylated alcohol is Octoxynol-40 and is present in an amount between 0.02 and 4% of the formulation. 
     
     
         15 . The ophthalmic formulation of  claim 1 , wherein said polyoxly lipid comprises one or more selected from the group consisting of HCO-40, HCO-60, HCO-80, HCO-100, polyoxyl 40 stearate and polyoxyl 35 castor oil and is present in an amount between 0.5-1.5% of the formulation; and said polyalkoxylated alcohol is Octoxynol-40 and is present in an amount between 0.02 and 0.1% of the formulation. 
     
     
         16 . The ophthalmic formulation of  claim 1 , wherein said polyoxly lipid comprises one or more selected from the group consisting of HCO-40, HCO-60, HCO-80, HCO-100, polyoxyl 40 stearate and polyoxyl 35 castor oil and is present in an amount between 0.5-5% of the formulation; said polyalkoxylated alcohol is Octoxynol-40 and is present in an amount between 0.02 and 4% of the formulation; and the cyclosporine is present in an amount between 0.05 and 5% of the formulation. 
     
     
         17 . The ophthalmic formulation of  claim 1 , wherein said polyoxly lipid comprises one or more selected from the group consisting of HCO-40, HCO-60, HCO-80, HCO-100, polyoxyl 40 stearate and polyoxyl 35 castor oil and is present in an amount between 0.5-1.5% of the formulation; and said polyalkoxylated alcohol is Octoxynol-40 and is present in an amount between 0.02 and 0.1% of the formulation; and the cyclosporine is present in an amount between 0.05 and 0.2% of the formulation. 
     
     
         18 . The ophthalmic formulation of  claim 1 , wherein said formulation comprises nanomicelles. 
     
     
         19 . A method of treating or preventing an ocular disease or condition, said method comprising topically administering a formulation of  claim 1 . 
     
     
         20 . A method of treating or preventing an ocular disease or condition, said method comprising topically administering a formulation of  claim 17 .