US2015148348A1PendingUtilityA1
Salts of 2-fluoro-n-methyl-4-[7-(quinolin-6-yl-methyl)- imidazo[1,2-b][1,2,4]triazin-2-yl]benzamide and processes related to preparing the same
Est. expiryMay 21, 2028(~1.8 yrs left)· nominal 20-yr term from priority
A61P 35/00A61P 35/02A61P 35/04A61P 9/00A61P 43/00A61P 37/02A61P 9/10A61P 37/08A61P 37/06A61P 29/00A61P 1/16A61P 11/00A61P 13/12C07D 401/10C07D 487/04C07D 253/07A61K 31/53
66
PatentIndex Score
0
Cited by
0
References
0
Claims
Abstract
The present invention is directed to dihydrochloric acid and dibenzenesulfonic acid salts of the c-Met kinase inhibitor 2-fluoro-N-methyl-4-[7-(quinolin-6-ylmethyl)-imidazo[1,2-b][1,2,4]triazin-2-yl]benzamide, and pharmaceutical compositions thereof, useful in the treatment of cancer and other diseases related to the dysregulation of kinase pathways. The present invention further relates to processes and intermediates for preparing 2-fluoro-N-methyl-4-[7-(quinolin-6-ylmethyl)imidazo[1,2-b][1,2,4]triazin-2-yl]benzamide, and salts thereof.
Claims
exact text as granted — not AI-modifiedWhat is claimed is:
1 - 34 . (canceled)
35 . A method of inhibiting tumor growth in a patient comprising administering to said patient a therapeutically effective amount of 2-fluoro-N-methyl-4-[7-(quinolin-6-ylmethyl)imidazo[1,2-b][1,2,4]triazin-2-yl]benzamide dihydrochloric acid salt, or a hydrate or solvate thereof.
36 . A method of inhibiting tumor metastasis in a patient comprising administering to said patient a therapeutically effective amount of 2-fluoro-N-methyl-4-[7-(quinolin-6-ylmethyl)imidazo[1,2-b][1,2,4]triazin-2-yl]benzamide dihydrochloric acid salt, or a hydrate or solvate thereof.
37 . A method of treating cancer in a patient, wherein said cancer is associated with dysregulation of the HGF/c-MET signaling pathway, comprising administering to said patient a therapeutically effective amount of 2-fluoro-N-methyl-4-[7-(quinolin-6-ylmethyl)imidazo[1,2-b][1,2,4]triazin-2-yl]benzamide dihydrochloric acid salt, or a hydrate or solvate thereof.
38 . (canceled)
39 . A method of treating a cancer in a patient comprising administering to said patient a therapeutically effective amount of 2-fluoro-N-methyl-4-[7-(quinolin-6-ylmethyl)imidazo[1,2-b][1,2,4]triazin-2-yl]benzamide dihydrochloric acid salt, or a hydrate or solvate thereof wherein said cancer is lung cancer, liver cancer, colorectal cancer, gastric cancer, glioblastoma, breast cancer, or cancer of the kidney.
40 - 83 . (canceled)
84 . The method of claim 39 , wherein said cancer is lung cancer.
85 . The method of claim 39 , wherein said cancer is liver cancer.
86 . The method of claim 39 , wherein said cancer is colorectal cancer.
87 . The method of claim 39 , wherein said cancer is gastric cancer.
88 . The method of claim 39 , wherein said cancer is glioblastoma.
89 . The method of claim 39 , wherein said cancer is breast cancer.
90 . The method of claim 39 , wherein said cancer is cancer of the kidney.Join the waitlist — get patent alerts
Track US2015148348A1 — get alerts on status changes and closely related new filings.
We store only your email — no account needed. See our privacy policy.