Compounds and compositions for treatment of cancer

Abstract

Compounds and compositions for treating, preventing or managing cancer are disclosed. The compositions provided herein comprise SNS-595 and N-desmethyl-SNS-595. Also provided are pharmaceutical compositions comprising the compounds and methods of treatment using the compounds and compositions.

1 . A composition comprising about 97% to about 99.99% by weight of (+)-1,4-dihydro-7-[(3S,4S)-3-methoxy-4-(methylamino)-1-pyrrolidinyl]-4-oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic acid and from about 0.01% up to about 3% by weight of an N-desmethyl (+)-1,4-dihydro-7-[(3S,4S)-3-methoxy-4-(methylamino)-1-pyrrolidinyl]-4-oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic acid, wherein each of the percentage is based upon total weight of the two components. 
     
     
         2 . The composition of  claim 1 , comprising about 0.8% by weight N-desmethyl (+)-1,4-dihydro-7-[(3S,4S)-3-methoxy-4-(methylamino)-1-pyrrolidinyl]-4-oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic acid. 
     
     
         3 . The composition of  claim 1 , comprising about 1.5% by weight N-desmethyl (+)-1,4-dihydro-7-[(3S,4S)-3-methoxy-4-(methylamino)-1-pyrrolidinyl]-4-oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic acid. 
     
     
         4 . The composition of  claim 1 , comprising about 98.5% by weight (+)-1,4-dihydro-7-[(3S,4S)-3-methoxy-4-(methylamino)-1-pyrrolidinyl]-4-oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic acid. 
     
     
         5 . The composition of  claim 1 , comprising about 99.2% by weight (+)-1,4-dihydro-7-[(3S,4S)-3-methoxy-4-(methylamino)-1-pyrrolidinyl]-4-oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic acid. 
     
     
         6 - 17 . (canceled) 
     
     
         18 . A method for treating cancer comprising administering the composition  claim 1  to a mammal in need of thereof. 
     
     
         19 . (canceled) 
     
     
         20 . The method of  claim 18 , wherein the composition is administered in a dose of about 1 mg/m 2 -150 mg/ to a mammal in need of thereof. 
     
     
         21 - 73 . (canceled)