Cyclosporin compositions

Abstract

A composition comprising a therapeutically effective amount of cyclosporin A, a blend of oils having a specific gravity of from 0.90 to 1.07, and a surfactant is disclosed herein.

What is claimed is: 
     
         1 . A method of treating keratoconjunctivitis sicca comprising administering a composition comprising a therapeutically effective amount of cyclosporin A, an oil having a specific gravity of from 0.90 to 1.07, and a surfactant to an eye of a patient in need thereof, wherein said composition is an ophthalmically acceptable emulsion. 
     
     
         2 . The method of  claim 1  wherein the oil has a specific gravity of from 0.95 to 1.07. 
     
     
         3 . The method of  claim 2 , wherein the composition comprises from about 0.001% to about 0.4% by weight cyclosporin A. 
     
     
         4 . The method of  claim 3 , wherein the composition comprises from about 0.001% to about 0.1% by weight cyclosporin A. 
     
     
         5 . The method of  claim 4 , wherein the composition comprises from about 0.005% to about 0.05% by weight cyclosporin A. 
     
     
         6 . The method of  claim 1 , wherein the surfactant is polysorbate 80. 
     
     
         7 . The method of  claim 1 , wherein the oil is selected from the group consisting of anise oil, castor oil, clove oil, or cinnamon oil. 
     
     
         8 . The method of  claim 7 , wherein the oil is castor oil. 
     
     
         9 . The method of  claim 1 , wherein the composition further comprises a second oil having a specificic gravity of less than 0.9. 
     
     
         10 . The method of  claim 8 , wherein the second oil is selected from the group consisting of mineral oil, coriander oil, lavender oil, juniper oil, and tea tree oil. 
     
     
         11 . The method of  claim 10 , wherein the second oil is mineral oil.