Analyte Sensors and Methods

Abstract

Methods of determining analyte concentration. The methods use a fraction of the predicted total charge, from analyte electrolysis, instead of using time, for determination of a data collection endpoint. The total charge is then extrapolated from the data collection endpoint. The analyte concentration is determined from the total charge.

1 - 8 . (canceled) 
     
     
         9 . A device for determining the concentration of an analyte in a sample, the device comprising:
 a sensor port for receiving an analyte sensor;   a display   a processor; and   a memory comprising instructions when executed by the processor cause the device to:
 electrolyze a sample deposited on the analyte sensor positioned in the sensor port; 
 measure current as a function of time; 
 predict a first signal value for complete electrolysis of the analyte from the measured current prior to a first time during electrolysis and an extrapolated current subsequent the first time during electrolysis; 
 determine a data collection endpoint, wherein the data collection endpoint is a predetermined percentage of the predicted first signal value; 
 calculate a second signal value from the measured current prior to the data collection endpoint and an extrapolated current subsequent the data collection point; and 
 determine the concentration of the analyte based on the calculated second signal value. 
   
     
     
         10 . The device of  claim 9 , wherein the first signal value is the sum of a measured signal and an extrapolated signal. 
     
     
         11 . The device of  claim 10 , wherein the signal is charge, and the first signal value is a predicted total charge for complete electrolysis. 
     
     
         12 . The device of  claim 11 , wherein the electrolysis comprises coulometry. 
     
     
         13 . The device of  claim 11 , wherein the extrapolated current subsequent the data collection point is an extrapolated linear current. 
     
     
         14 . The device of  claim 13 , wherein determining the second signal value comprises:
 integrating the extrapolated linear current and the measured current prior to the data collection endpoint.   
     
     
         15 . The device of  claim 9 , wherein electrolysis comprises amperometry. 
     
     
         16 . The method of  claim 13 , wherein the extrapolated linear current is calculated based on the measured current prior to the data collection point and the data collection point. 
     
     
         17 . The device of  claim 9 , wherein the extrapolated linear current is calculated based on only a portion of the measured current prior to the data collection point and the data collection point.