US2015174254A1PendingUtilityA1

Topical gel compositions including polycaprolactone polymer and methods for enhancing the topical application of a benefit agent

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Assignee: MCNEIL PPC INCPriority: Dec 23, 2013Filed: Dec 23, 2013Published: Jun 25, 2015
Est. expiryDec 23, 2033(~7.4 yrs left)· nominal 20-yr term from priority
Inventors:Ying SunAnna GosiewskaDennis D. JamiolkowskiJeffrey M. Wu
A61P 43/00A61P 29/00A61P 31/12A61P 25/04A61P 31/04A61P 17/14A61P 17/00A61P 17/10A61K 8/34A61K 47/34A61K 8/85A61Q 19/08A61Q 19/00A61K 9/0014A61K 31/506A61Q 19/02A61K 8/4953A61Q 7/00A61K 47/10A61K 2800/591A61K 8/345A61K 8/042
61
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Claims

Abstract

A composition comprising: a benefit agent; at least one polymer including a polycaprolactone polymer; at least one lower alcohol; and at least one co-solvent; and a method for enhancing topical delivery of a benefit agent is disclosed.

Claims

exact text as granted — not AI-modified
We claim: 
     
         1 . A topical composition comprising:
 a benefit agent;   at least one polymer including a polycaprolactone polymer;   at least one lower alcohol;   and at least one co-solvent.   
     
     
         2 . The topical composition according to  claim 1 , wherein
 wherein the benefit agent is selected from the group consisting of hair growth agents, anti-acne and/or anti-rosacea agents, anti-aging agents, depigmentation agent, anti-microbial agents, anti-viral agents, anti-inflammatory agents and analgesics,   the polycaprolactone polymer is selected from the group consisting of hydroxypolycaprolactone; polycaprolactone diol; polycaprolactone triol; α, ω-dihydroxy oligo(ε-caprolactone); α-carboxy, ω-hydroxy poly(ε-caprolactone) α, ω-dicarboxy poly(ε-caprolactone) and mixtures thereof;   the at least one lower alcohol is selected from the group consisting of ethyl alcohol, n-propyl alcohol, isopropyl alcohol, n-butyl alcohol, isobutyl alcohol, amyl alcohol, benzyl alcohol, octyldocanol, hexyldecanol, butyloctanol, and mixtures thereof; and   the at least one co-solvent is selected from the group consisting of glycerol, polyglycerols, glycols, polyglycols, and mixtures thereof.   
     
     
         3 . The topical composition according to  claim 2 , wherein the polycaprolactone polymer is polycaprolactone diol polymer. 
     
     
         4 . The topical composition according to  claim 2 , wherein the polyglycerols are selected from the group consisting of diglycerol, triglycerol, tetraglycerol, polyglycerol-n, where n>4, and mixtures thereof. 
     
     
         5 . The topical composition according to  claim 2 , wherein the glycols are selected from the group consisting of propylene glycol, ethylene glycol, butylene glycol, 1,2-butanediol, 1,3-butanediol, 1,4-butanediol, 2,3-butanediol, pentylene glycol, hexylene glycol, propanediol, dipropylene glycol, ethoxydiglycol, methylpropanediol, isopentyldiol, and mixtures thereof. 
     
     
         6 . The topical composition according to  claim 2  wherein the polyglycols are selected from the group consisting of polyethylene glycol, polypropylene glycol and mixtures thereof. 
     
     
         7 . The topical composition according to  claim 2 , wherein the benefit agent is minoxidil. 
     
     
         8 . The topical composition according to  claim 2 , wherein
 the benefit agent is in an amount from about 0.001% to about 20% by weight of the composition;   the polycaprolactone polymer is polycaprolactone diol polymer in an amount from about 0.05% to about 20% by weight of the composition;   the lower alcohol is in an amount from about 2% to about 90% by weight of the composition; and   the co-solvent is in an amount from about 1% to about 50% by weight of the composition.   
     
     
         9 . The topical composition according to  claim 8 , wherein
 the benefit agent is in an amount from about 0.01% to about 10% by weight of the composition;   the polycaprolactone diol polymer is in an amount from about 1% to about 10% by weight of the composition;   the lower alcohol is in an amount from about 5% to about 40% by weight of the composition; and   the co-solvent is in an amount from about 5% to about 40% by weight of the composition.   
     
     
         10 . The topical composition according to  claim 9 , wherein
 the benefit agent is in an amount from about 1% to about 5% by weight of the composition;   the polycaprolactone diol polymer is in an amount from about 1% to about 5% by weight of the composition;   the lower alcohol is in an amount from about 10% to about 30% by weight of the composition; and   the co-solvent is an amount from about 10% to about 20% by weight of the composition.   
     
     
         11 . The topical composition according to  claim 10 , wherein the benefit agent is minoxidil. 
     
     
         12 . A method for enhancing the topical application of a benefit agent which comprises topically administering to a human or animal a composition comprising a composition according to  claim 1 . 
     
     
         13 . The method according to  claim 12 , wherein the polycaprolactone polymer is polycaprolactone diol polymer. 
     
     
         14 . The method according to  claim 12 , wherein
 the benefit agent is selected from the group consisting of hair growth agents, anti-acne and/or anti-rosacea agents, anti-aging agents, depigmentation agent, anti-microbial agents, anti-viral agents, anti-inflammatory agents and analgesics,   the polycaprolactone polymer is selected from the group consisting of hydroxypolycaprolactone; polycaprolactone diol; polycaprolactone triol; α, ω-dihydroxy oligo(ε-caprolactone); α-carboxy, ω-hydroxy poly(ε-caprolactone) α, ω-dicarboxy poly(ε-caprolactone) and mixtures thereof;   the at least one lower alcohol is selected from the group consisting of ethyl alcohol, n-propyl alcohol, isopropyl alcohol, n-butyl alcohol, isobutyl alcohol, amyl alcohol, benzyl alcohol, octyldocanol, hexyldecanol, butyloctanol, and mixtures thereof; and   the at least one co-solvent is selected from the group consisting of glycerol, polyglycerols, glycols, polyglycols, and mixtures thereof.   
     
     
         15 . The method according to  claim 14 , wherein the polyglycerols are selected from the group consisting of diglycerol, triglycerol, tetraglycerol, polycerol-n, where n>4, and mixtures thereof. 
     
     
         16 . The method according to  claim 14 , wherein the glycols are selected from the group consisting of propylene glycol, ethylene glycol, butylene glycol, 1,2-butanediol, 1,3-butanediol, 1,4-butanediol, 2,3-butanediol, pentylene glycol, hexylene glycol, propanediol, dipropylene glycol, ethoxydiglycol, methylpropanediol, isopentyldiol, and mixtures thereof. 
     
     
         17 . The method according to  claim 14 , wherein the polyglycols are selected from the group consisting of polyethylene glycol, polypropylene glycol and mixtures thereof. 
     
     
         18 . The method according to  claim 12 , wherein the composition comprises
 a benefit agent in an amount from about 0.001% to about 20% by weight of the composition;   polycaprolactone diol polymer in an amount from about 0.05% to about 20% by weight of the composition;   a lower alcohol in an amount from about 2% to about 90% by weight of the composition; and   a co-solvent in an amount from about 1% to about 50% by weight of the composition.   
     
     
         19 . The method according to  claim 18 , wherein the composition comprises
 a benefit agent in an amount from about 0.01% to about 10% by weight of the composition;   polycaprolactone diol polymer in an amount from about 1% to about 10% by weight of the composition;   a lower alcohol in an amount from about 5% to about 40% by weight of the composition; and   a co-solvent in an amount from about 5% to about 40% by weight of the composition.   
     
     
         20 . The method according to  claim 19 , wherein the composition comprises
 a benefit agent in an amount from about 1% to about 5% by weight of the composition;   polycaprolactone diol polymer in an amount from about 1% to about 5% by weight of the composition;   a lower alcohol in an amount from about 10% to about 30% by weight of the composition; and   a co-solvent in an amount from about 10% to about 20% by weight of the composition.   
     
     
         21 . The method according to  claim 20 , wherein the benefit agent is minoxidil. 
     
     
         22 . The method according to  claim 13 , wherein the benefit agent is minoxidil. 
     
     
         23 . A topical composition comprising
 minoxidil in an amount from about 1% to about 5% by weight of the composition;   polycaprolactone diol in an amount from about 1% to about 5% by weight of the composition;   ethyl alcohol in an amount from about 15% to about 25% by weight of the composition; and   a co-solvent in an amount from about 10% to about 20% by weight of the composition.

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