Endovascular occlusion device with hemodynamically enhanced sealing and anchoring

Abstract

The present disclosure describes an occlusion device and methods of delivering the occlusion device. The occlusion device can include an expandable structure configured to move between an unexpanded configuration and an expanded configuration. The occlusion device is configured such that arterial blood pressure enhances both sealing with the vessel wall and anchoring against migration. The expandable structure can be configured to have an expansion ratio of at least about 5:1. Further, the occlusion device can be configured to mechanically prevent substantially all fluid from flowing past the occlusion device when the occlusion device is in the expanded configuration in the vessel.

What is claimed is: 
     
         1 . An endovascular occlusion device for occluding blood flow in a vessel, comprising:
 a support structure, self-expandable from a reduced cross section for transluminal navigation to an enlarged cross section for occluding a vessel;   the support structure defining a concave occlusion component and an anchoring component separated by a neck portion;   wherein the support structure is configured such that blood pressure against the concave occlusion component provides a radially outwardly directed force to seal the occlusion component against the vessel wall, and an axially directed force against the neck which increases a radial force between the anchoring component and the vessel wall.   
     
     
         2 . An endovascular occlusion device as in  claim 1 , wherein the support structure has an expansion ratio of at least about 6:1. 
     
     
         3 . An endovascular occlusion device as in  claim 1 , wherein the support structure has an expansion ratio of at least about 8:1. 
     
     
         4 . An endovascular occlusion device as in  claim 1 , comprising a guidewire lumen extending through the neck portion. 
     
     
         5 . An endovascular occlusion device as in  claim 4 , further comprising a valve for occluding the guidewire lumen. 
     
     
         6 . An endovascular occlusion device as in  claim 5 , wherein the valve comprises a collapsible tubular sleeve. 
     
     
         7 . An endovascular occlusion device as in  claim 6 , wherein the tubular sleeve is configured to collapse under arterial blood pressure following removal of a guidewire from the tubular sleeve. 
     
     
         8 . An endovascular occlusion device as in  claim 4 , configured for transluminal delivery over a 0.018 inch diameter guidewire. 
     
     
         9 . An endovascular occlusion device as in  claim 1 , wherein the occlusion component comprises an occlusive membrane carried by the support structure. 
     
     
         10 . An endovascular occlusion device as in  claim 9 , wherein the membrane has an average thickness of no more than about 30 microns. 
     
     
         11 . An endovascular occlusion device as in  claim 1 , configured for deployment with the occlusion component concave in an upstream blood flow orientation, and the anchoring component is concave in a downstream direction. 
     
     
         12 . An endovascular occlusion device as in  claim 1 , wherein the support structure is expandable through a range of expansion sufficient to occlude blood vessels having inside diameters anywhere within the range from about 2.5 mm to about 8 mm. 
     
     
         13 . An endovascular occlusion device as in  claim 12 , wherein the reduced cross section is small enough that the occlusion device is deployable from a lumen having an inside diameter of no more than about 2 mm. 
     
     
         14 . An endovascular occlusion device as in  claim 1 , wherein the device has an average COP across a diameter of 2.5 mm to 8.0 mm of between about 30 mmHg and about 140 mmHg. 
     
     
         15 . An endovascular occlusion device as in  claim 1 , configured to achieve a total mechanical occlusion of blood flow following deployment in a blood vessel. 
     
     
         16 . An endovascular occlusion device as in  claim 1 , configured to achieve a reduction in blood flow of at least about 80% within 1 minute of deployment in a blood vessel. 
     
     
         17 . An endovascular occlusion device as in  claim 1 , configured to achieve total occlusion within 5 minutes of deployment in a blood vessel. 
     
     
         18 . An endovascular occlusion device as in  claim 17 , configured to achieve total occlusion within 1 minute of deployment in a blood vessel. 
     
     
         19 . An endovascular occlusion device as in  claim 1 , wherein the neck portion is flexible so that the neck does not kink when the device is deployed in a curved vessel. 
     
     
         20 . An endovascular occlusion device as in  claim 11 , wherein the occlusion component has an axial length that is greater than an axial length of the anchoring component.