US2015196503A1PendingUtilityA1

Co-crystals of tramadol and coxibs

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Assignee: ESTEVE LABOR DRPriority: Oct 17, 2008Filed: Mar 23, 2015Published: Jul 16, 2015
Est. expiryOct 17, 2028(~2.2 yrs left)· nominal 20-yr term from priority
Inventors:Carlos Ramon Plata SalamanNicolas Tesson
A61P 43/00A61P 3/10A61P 25/04A61P 25/00A61P 29/00A61P 19/00A61P 21/00A61P 19/02A61K 31/635C07B 2200/13C07C 59/64A61K 31/135C07C 217/74A61K 9/16A61K 31/137C07C 2602/10C07C 2601/14A61K 45/06C07D 231/12A61K 31/192A61P 25/02A61K 31/415
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Claims

Abstract

The present invention relates to co-crystals of tramadol and co-crystal formers selected from NSAIDs/coxibs, processes for preparation of the same and their uses as medicaments or in pharmaceutical formulations, more particularly for the treatment of pain.

Claims

exact text as granted — not AI-modified
1 . A co-crystal comprising (rac)-tramadol.HCl and celecoxib in a molecular ratio of 1:1, characterized in that it has an orthorhombic unit cell with the following dimensions:
 a=11.0323(7) Å   b=18.1095(12) Å   c=17.3206(12) Å.   
     
     
         2 . A co-crystal according to  claim 1 , characterized in that it shows a Fourier Transform Infra Red pattern with absorption bands at 3481.6 (m), 3133.5 (m), 2923.0 (m), 2667.7 (m), 1596.0 (m), 1472.4 (m), 1458.0 (m), 1335.1 (m), 1288.7 (m), 1271.8 (m), 1168.7 (s), 1237.3 (m), 1168.7 (s), 1122.6 (s), 1100.9 (m), 1042.2 (m), 976.8 (m), 844.6 (m), 820.1 (m), 786.5 (m) 625.9 (m) cm −1 . 
     
     
         3 . Pharmaceutical composition characterized in that it comprises a therapeutically effective amount of the co-crystal according to  claim 1  in a physiologically acceptable medium. 
     
     
         4 . Pharmaceutical composition characterized in that it comprises a therapeutically effective amount of the co-crystal according to  claim 2  in a physiologically acceptable medium.

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