US2015196504A1PendingUtilityA1

Co-crystals of tramadol and coxibs

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Assignee: ESTEVE LABOR DRPriority: Oct 17, 2008Filed: Mar 23, 2015Published: Jul 16, 2015
Est. expiryOct 17, 2028(~2.2 yrs left)· nominal 20-yr term from priority
Inventors:Carlos Ramon Plata SalamanNicolas Tesson
A61P 3/10A61P 43/00A61P 25/00A61P 29/00A61P 25/04A61P 19/02A61P 21/00A61P 19/00C07C 2601/14C07B 2200/13A61K 31/135C07C 2602/10C07D 231/12C07C 217/74C07C 59/64A61K 31/137A61K 31/635A61K 45/06A61K 9/16A61K 31/192A61P 25/02A61K 31/415
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Claims

Abstract

The present invention relates to co-crystals of tramadol and co-crystal formers selected from NSAIDs/coxibs, processes for preparation of the same and their uses as medicaments or in pharmaceutical formulations, more particularly for the treatment of pain.

Claims

exact text as granted — not AI-modified
The invention claimed is: 
     
         1 . A co-crystal comprising (rac)-tramadol.HCl and celecoxib in a molecular ratio of 1:1, characterized in that it shows a Powder X-Ray Diffraction pattern with peaks [2θ] at 14.1, 16.8, 19.0 and 22.7[° ], with the 2θ values being obtained using copper radiation (CuKα1 1.54060 Å). 
     
     
         2 . A co-crystal comprising (rac)-tramadol.HCl and celecoxib in a molecular ratio of 1:1 according to  claim 1 , characterized in that it shows a Powder X-Ray Diffraction pattern with peaks [2θ] at 7.1, 19.9 and 20.5[° ], with the 2θ values being obtained using copper radiation (CuKα1 1.54060 Å). 
     
     
         3 . A co-crystal comprising (rac)-tramadol.HCl and celecoxib in a molecular ratio of 1:1 according to  claim 2 , characterized in that it shows a Powder X-Ray Diffraction pattern with peaks [2θ] at 13.6, 13.9, 17.5, 18.0, 19.5, 21.2, 21.3, 21.8, 22.6, 23.6, 24.1, 24.4 and 26.1 [° ], with the 2θ values being obtained using copper radiation (CuKα1 1.54060 Å). 
     
     
         4 . Method of treatment of pain, comprising administering to a patient in need thereof an effective amount of a co-crystal as defined in  claim 1 . 
     
     
         5 . Method of treatment of pain, comprising administering to a patient in need thereof an effective amount of a co-crystal as defined in  claim 2 . 
     
     
         6 . Method of treatment of pain, comprising administering to a patient in need thereof an effective amount of a co-crystal as defined in  claim 3 .

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