Combination therapy for acne vulgaris comprising administration of adapalene 0.3% gel and clindamycin/benzoyl peroxide gel

Abstract

A novel regime or regimen for the treatment of acne related diseases and particularly acne vulgaris includes administering to a patient in need of such treatment a therapeutically effective amount of Differin gel 0.3% (adapalene) in association or combination with a combined clindamycin/benzoyl peroxide gel product such as DUAC®.

1 .- 13 . (canceled) 
     
     
         14 . A method for inhibiting or treating moderate to severe acne, comprising topically administering to an individual subject having moderate to severe acne in need of such treatment, for such period of time as required to elicit the desired effect, a therapeutically effective amount of an adapalene composition comprising 0.3% by weight of adapalene, once a day, and a combined clindamycin benzoyl peroxide medicament comprising 1% by weight of clindamycin and 5% by weight of benzoyl peroxide, once a day, the adapalene composition being applied in the evening and the combined clindarnycin/benzoyl peroxide medicament being applied in the morning. 
     
     
         15 . The method as defined by  claim 14 , wherein the adapalene composition comprises a gel or cream. 
     
     
         16 . The method as defined by  claim 14 , wherein the combined clindamycin/benzoyl peroxide medicament comprises a gel. 
     
     
         17 . The method as defined by  claim 14 , wherein treatment is carried out for a period of time of from 10 to 16 weeks. 
     
     
         18 . The method as defined by  claim 17 , wherein treatment is carried out for a period of time of from 12 to 14 weeks. 
     
     
         19 . A method for treatment of moderate to severe acne vulgaris, comprising administering to an individual subject having moderate to severe acne in need of such treatment, for such period of time as required to elicit the desired effect, a therapeutically effective amount of an adapalene composition comprising 0.3% by weight of adapalene, once a day, and a combined clindamycin/benzoyl peroxide medicament comprising 1% by weight of clindamycin and 5% by weight of benzoyl peroxide, once a day, the adapalene composition being applied in the evening and the combined clindamycin/benzoyl peroxide medicament being applied in the morning.