Energetic modulation of nerves

Abstract

A method to deliver focused ultrasound energy from a position outside a skin of a patient to a nerve surrounding a blood vessel, includes placing the patient on a table in a substantially flat position, moving a transducer into a position inferior to ribs, superior to an iliac crest, and lateral to a spine of the patient, maintaining the transducer at the position relative to the patient, and delivering focused ultrasound energy through the skin of the patient without traversing bone, wherein the direction of the focused ultrasound is directed from a lower torso to an upper torso of the patient.

1 . A system for treatment of one or more nerves next to a blood vessel leading to a kidney comprising:
 an ultrasound energy source for placement outside a patient, wherein the ultrasound energy source comprises an array of ultrasound transducers; and   a programmable controller configured to control a phasing for one or more elements in the array of ultrasound transducers, to sequentially deliver focused ultrasound to a plurality of target areas next to the blood vessel leading to the kidney;   wherein the controller is configured to update a position of one of the plurality of target areas to correlate with a current vessel position;   wherein the controller is configured to control the ultrasound energy source to place an energy focus at a first one of the target areas in accordance with a vessel position at a first time instance, and to place the energy focus at a second one of the target areas in accordance with the vessel position at a second time instance; and   wherein the vessel position at the first time instance is different from the vessel position at the second time instance.   
     
     
         2 . The system of  claim 1 , further comprising an intravascular catheter device for placement into the vessel, wherein the intravascular catheter device is configured to provide an indication of a position associated with one of the target areas. 
     
     
         3 . The system of  claim 2 , wherein the intravascular catheter device comprises a signal transmitting component to provide a signal, and the controller is configured to operate the ultrasound energy source in dependence on the signal. 
     
     
         4 . The system of  claim 1 , further comprising a positioning device for moving the ultrasound energy source, wherein the programmable controller is configured to control the position of the ultrasound energy source by controlling the positioning device. 
     
     
         5 . The system of  claim 1 , wherein the ultrasound energy source is configured to deliver the focused ultrasound to a tissue depth that is anywhere from 6 cm to 15 cm below a skin surface. 
     
     
         6 . The system of  claim 1 , further comprising a motion tracking system coupled to the controller. 
     
     
         7 . The system of  claim 1 , further comprising a magnetic resonance imaging system having a permanent magnet, wherein the magnetic resonance imaging system is operatively coupled to the programmable controller. 
     
     
         8 . The system of  claim 1 , further comprising an imaging apparatus for providing an output to the controller, wherein the controller is configured to control the ultrasound energy source in dependence on the output from the imaging apparatus. 
     
     
         9 . The system of  claim 8 , wherein the imaging apparatus comprises an ultrasound imaging device. 
     
     
         10 . The system of  claim 8 , wherein the imaging apparatus comprises a motion tracking system. 
     
     
         11 . The system of  claim 10 , wherein the motion tracking system is configured to track speckles. 
     
     
         12 . The system of  claim 1 , further comprising a MRI for imaging the patient. 
     
     
         13 . The system of  claim 12 , wherein the MRI comprises a radiofrequency coil for placement around an abdomen of the patient, and wherein the radiofrequency coil is configured to provide a radiofrequency field for imaging purpose. 
     
     
         14 . A device to apply focused ultrasound to a patient comprising:
 a transducer configured to deliver focused ultrasound to a plurality of target areas next to a blood vessel leading to a kidney, wherein the transducer comprises a plurality of individually phaseable elements, and a membrane for coupling the ultrasound to the patient; and   a controller for controlling the phaseable elements to change a position of a focus of the transducer;   wherein the controller is configured to update a position of one of the plurality of target areas to correlate with a current vessel position;   wherein the controller is configured to control the transducer to place an energy focus at a first one of the target areas in accordance with a vessel position at a first time instance, and to place the energy focus at a second one of the target areas in accordance with the vessel position at a second time instance; and   wherein the vessel position at the first time instance is different from the vessel position at the second time instance.   
     
     
         15 . The device of  claim 14 , wherein the membrane contains fluid, and the device further comprises a control unit for maintaining a pressure and a temperature of the fluid at respective levels. 
     
     
         16 . The device of  claim 14 , further comprising an imaging system coupled to the controller. 
     
     
         17 . The device of  claim 16 , wherein the imaging system is an MRI system. 
     
     
         18 . The device of  claim 16 , wherein the imaging system is an ultrasound system. 
     
     
         19 . The device of  claim 16 , wherein the imaging system is configured to detect an intravascular catheter. 
     
     
         20 . The device of  claim 16 , wherein the imaging system is configured to determine a three dimensional coordinate, and the transducer is configured to deliver the ultrasound in dependence on the determined three dimensional coordinate. 
     
     
         21 . The device of  claim 14 , further comprising a mechanical device for maintaining a pressure between the membrane of the transducer and a skin of the patient. 
     
     
         22 . The device of  claim 14 , further comprising an intravascular catheter configured to provide an indication of a position associated with one of the target areas. 
     
     
         23 . The device of  claim 14 , wherein the transducer is configured to deliver the focused ultrasound to a tissue depth that is anywhere from 6 cm to 15 cm below a skin surface.