Linear cyclodextrin copolymers

Abstract

Linear cyclodextrin copolymers and linear oxidized cyclodextrin copolymers containing an unoxidized and/or an oxidized cyclodextrin moiety integrated into the polymer backbone are described. Methods of preparing such copolymers are also described. The linear cyclodextrin copolymer and linear oxidized cyclodextrin copolymer of the invention may be used as a delivery vehicle of various therapeutic agents.

1 - 37 . (canceled) 
     
     
         38 . A method of preparing a linear oxidized cyclodextrin copolymer comprising the steps of:
 (a) iodinating an oxidized cyclodextrin monomer precursor to form an oxidized diiodinated cyclodextrin monomer precursor of formula VIIa, VIIb, VIIc or a mixture thereof:   
       
         
           
           
               
               
           
         
       
       and
 (b) copolymerizing said oxidized diiodinated cyclodextrin monomer precursor with a comonomer A precursor to form a linear oxidized cyclodextrin copolymer having a repeating unit of formula VIa, VIb, or a combination thereof 
 
       
         
           
           
               
               
           
         
       
       wherein C is a substituted or unsubstituted oxidized cyclodextrin monomer and A is a comonomer bound to the cyclodextrin monomer C. 
     
     
         39 . A method of  claim 38  further comprising the step of reacting said linear oxidized cyclodextrin copolymer with a ligand to form a linear oxidized cyclodextrin copolymer having at least one ligand bound to the copolymer. 
     
     
         40 . A method of  claim 38  further comprising the steps of aminating said oxidized diiodinated cyclodextrin monomer precursor to form an oxidized diaminated cyclodextrin monomer precursor of formula VIIIa, VIIIb, VIIIc or a mixture thereof: 
       
         
           
           
               
               
           
         
         copolymerizing said oxidized diaminated cyclodextrin monomer precursor with a comonomer A precursor to form said linear oxidized cyclodextrin copolymer having a repeating unit of formula VIa, VIb, or a combination thereof. 
       
     
     
         41 . A method of  claim 38  further comprising the steps of aminating said oxidized diiodinated cyclodextrin monomer precursor to form an oxidized diaminated cyclodextrin monomer precursor of formula IXa, IXb, IXc or a mixture thereof: 
       
         
           
           
               
               
           
         
       
     
     
         42 - 45 . (canceled)