US2015209349A1PendingUtilityA1
Piperazine Compounds
Est. expiryJan 9, 2028(~1.5 yrs left)· nominal 20-yr term from priority
A61P 43/00A61P 37/06A61P 35/04A61P 33/02A61P 33/08A61P 29/00A61P 35/00A61P 31/12A61P 3/14A61P 25/00A61P 33/06A61P 33/12A61P 21/00A61P 1/02A61P 19/02A61P 19/08A61P 19/00A61P 19/10A61P 21/04C07D 491/048A61K 31/496Y02A50/30
47
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Abstract
A compound of formula (I), or a pharmaceutically acceptable salt, hydrate, complex or pro-drug thereof, wherein one of R 1 and R 2 is H, and the other is selected from C 1-8 -alkyl, C 3-6 -cycloalkyl and C 1-8 -alkyl-C 5-10 -aryl; R 3 is selected from tert-butylmethyl, iso-propylmethyl, sec-butyl, tert-butyl, cyclopentyl, cyclohexyl and 1-methylcyclopentyl; R 9 is selected from the following: wherein: R 4 is selected from C 1-8 -alkyl and C 3-8 -cycloalkyl; G is selected from: CH, CMe and N; E is selected from: O, S, SO 2 , NH, NMe and N-oxide ( N→O); J and R are independently selected from: CH, N and N-oxide ( N→O); and R 41 is selected from amino, methylamino, dimethylamino, isopropylamino, isopropyl(methyl)amino, cyclopropylamino, cyclopropyl (methyl) amino, cyclopentylamino, morpholino, piperidin-1-yl, piperidin-1-ylmethyl, morpholinomethyl, 4-methylpiperazin-1-yl, 4-(2-methoxyethyl)piperazin-1-yl, 1-morpholino ethyl, 1-(dimethyl amino)ethyl, 1-(methyl amino)ethyl, 4-fluoro-1-methylpyrrolidin-2-yl, 4,4-difluoropiperidin-1-yl, piperidin-4-yl, 1-methylpiperidin-4-yl, pyridin-3-ylamino, pyridin-2-ylamino, 1-methylpyrrolidin-3-yl, methyl, isopropyl. The invention further relates to pharmaceutical compositions comprising compounds of formula (I), and the use of such compounds in the treatment of various diseases.
Claims
exact text as granted — not AI-modifiedThe invention claimed is:
1 . A method of inhibiting activity of Cathepsin K in a cell or in a subject, said method comprising contacting said cell with or administering to said subject a compound of formula (I), or a pharmaceutically acceptable salt, or hydrate thereof,
wherein:
one of R 1 and R 2 is H, and the other is selected from C 1-8 -alkyl, C 2-8 -alkynyl, C 3-6 -cycloalkyl and C 1-8 -alkyl-C 5-10 -aryl;
R 3 is selected from tert-butylmethyl, iso-propylmethyl, sec-butyl, tert-butyl, cyclopentyl, cyclohexyl and 1-methylcyclopentyl;
R 9 is selected from the following:
wherein:
R 4 is selected from C 1-8 -alkyl and C 3-8 -cycloalkyl.
2 . The method of claim 1 , wherein said contacting or administering is with a compound of formula Ia:
wherein R 1 , R 2 , R 3 and R 9 are as defined in claim 1 .
3 . The method of claim 1 , wherein one of said R 1 and R 2 is H, and the other is selected from methyl, ethyl, propyl, iso-propyl, tert-butyl, cyclopropyl, cyclopropylmethyl, iso-propylmethyl, tert-butylmethyl, CH 2 OH, CH 2 OMe, CH 2 OCH 2 Ph, CH 2 Ph, CH 2 F and CHF 2 .
4 . The method of claim 1 , wherein one of R 1 and R 2 is H, and the other is C 1-8 -alkyl.
5 . The method of claim 1 , wherein one of R 1 and R 2 is H, and the other is selected from methyl, ethyl, iso-propyl and CHF 2 .
6 . The method of claim 1 , wherein R 3 is selected from tert-butylmethyl, iso-propylmethyl, sec-butyl, tert-butyl, cyclopentyl and cyclohexyl.
7 . The method of claim 1 , wherein R 3 is cyclopentyl or tert-butyl.
8 . The method of claim 1 , wherein R 4 is C 1-8 -alkyl
9 . The method of claim 1 , wherein R 4 is selected from methyl, ethyl and propyl.
10 . The method of claim 1 , wherein one of R 1 and R 2 is H, and the other is C 2-8 -alkynyl.
11 . The method of claim 1 , wherein R 9 is:
12 . The method of claim 1 , wherein said compound is selected from the following:
1) N-((S)-4-methyl-1-((3aS,6R,6aR)-6-methyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-1-oxopentan-2-yl)-4-(4-methylpiperazin-1-yl)benzamide 2) 4-(4-ethylpiperazin-1-yl)-N-((S)-4-methyl-1-((3aS,6R,6aR)-6-methyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-1-oxopentan-2-yl)benzamide 3) N-((S)-4-methyl-1-((3aS,6R,6aR)-6-methyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-1-oxopentan-2-yl)-4-(4-propylpiperazin-1-yl)benzamide 4) N-((S)-1-((3aS,6R,6aR)-6-ethyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-4-methyl-1-oxopentan-2-yl)-4-(4-methylpiperazin-1-yl)benzamide 5) N-((S)-1-((3aS,6R,6aR)-6-ethyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-4-methyl-1-oxopentan-2-yl)-4-(4-ethylpiperazin-1-yl)benzamide 6) N-((S)-1-((3aS,6R,6aR)-6-ethyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-4-methyl-1-oxopentan-2-yl)-4-(4-propylpiperazin-1-yl)benzamide 7) N-((S)-4-methyl-1-oxo-1-((3aS,6R,6aR)-3-oxo-6-propyldihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)pentan-2-yl)-4-(4-methylpiperazin-1-yl)benzamide 8) 4-(4-ethylpiperazin-1-yl)-N-((S)-4-methyl-1-oxo-1-((3aS,6R,6aR)-3-oxo-6-propyldihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)pentan-2-yl)benzamide 9) N-((S)-4-methyl-1-oxo-1-((3aS,6R,6aR)-3-oxo-6-propyldihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)pentan-2-yl)-4-(4-propylpiperazin-1-yl)benzamide 10) N-((S)-1-((3aS,6R,6aR)-6-isopropyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-4-methyl-1-oxopentan-2-yl)-4-(4-methylpiperazin-1-yl)benzamide 11) N-((S)-1-((3aS,6R,6aR)-6-isopropyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-4-methyl-1-oxopentan-2-yl)-4-(4-ethylpiperazin-1-yl)benzamide 12) N-((S)-1-((3aS,6R,6aR)-6-isopropyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-4-methyl-1-oxopentan-2-yl)-4-(4-propylpiperazin-1-yl)benzamide 13) N-((S)-1-((3aS,6R,6aR)-6-tert-butyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-4-methyl-1-oxopentan-2-yl)-4-(4-methylpiperazin-1-yl)benzamide 14) N-((S)-1-((3aS,6R,6aR)-6-tert-butyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-4-methyl-1-oxopentan-2-yl)-4-(4-ethylpiperazin-1-yl)benzamide 15) N-((S)-1-((3aS,6R,6aR)-6-tert-butyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-4-methyl-1-oxopentan-2-yl)-4-(4-propylpiperazin-1-yl)benzamide 16) N-((S)-1-((3aS,6R,6aR)-6-cyclopropyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-4-methyl-1-oxopentan-2-yl)-4-(4-methylpiperazin-1-yl)benzamide 17) N-((S)-1-((3aS,6R,6aR)-6-cyclopropyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-4-methyl-1-oxopentan-2-yl)-4-(4-ethylpiperazin-1-yl)benzamide 18) N-((S)-1-((3aS,6R,6aR)-6-cyclopropyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-4-methyl-1-oxopentan-2-yl)-4-(4-propylpiperazin-1-yl)benzamide 19) N-((S)-1-((3aS,6R,6aR)-6-(difluoromethyl)-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-4-methyl-1-oxopentan-2-yl)-4-(4-methylpiperazin-1-yl)benzamide 20) N-((S)-1-((3aS,6R,6aR)-6-(difluoromethyl)-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-4-methyl-1-oxopentan-2-yl)-4-(4-ethylpiperazin-1-yl)benzamide 21) N-((S)-1-((3aS,6R,6aR)-6-(difluoromethyl)-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-4-methyl-1-oxopentan-2-yl)-4-(4-propylpiperazin-1-yl)benzamide 22) N-((S)-4,4-dimethyl-1-((3aS,6R,6aR)-6-methyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-1-oxopentan-2-yl)-4-(4-methylpiperazin-1-yl)benzamide 23) N-((S)-4,4-dimethyl-1-((3aS,6R,6aR)-6-methyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-1-oxopentan-2-yl)-4-(4-ethylpiperazin-1-yl)benzamide 24) N-((S)-4,4-dimethyl-1-((3aS,6R,6aR)-6-methyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-1-oxopentan-2-yl)-4-(4-propylpiperazin-1-yl)benzamide 25) N-((S)-1-((3aS,6R,6aR)-6-ethyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-4,4-dimethyl-1-oxopentan-2-yl)-4-(4-methylpiperazin-1-yl)benzamide 26) N-((S)-1-((3aS,6R,6aR)-6-ethyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-4,4-dimethyl-1-oxopentan-2-yl)-4-(4-ethylpiperazin-1-yl)benzamide 27) N-((S)-1-((3aS,6R,6aR)-6-ethyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-4,4-dimethyl-1-oxopentan-2-yl)-4-(4-propylpiperazin-1-yl)benzamide 28) N-((S)-4,4-dimethyl-1-oxo-1-((3aS,6R,6aR)-3-oxo-6-propyldihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)pentan-2-yl)-4-(4-methylpiperazin-1-yl)benzamide 29) N-((S)-4,4-dimethyl-1-oxo-1-((3aS,6R,6aR)-3-oxo-6-propyldihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)pentan-2-yl)-4-(4-ethylpiperazin-1-yl)benzamide 30) N-((S)-4,4-dimethyl-1-oxo-1-((3aS,6R,6aR)-3-oxo-6-propyldihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)pentan-2-yl)-4-(4-propylpiperazin-1-yl)benzamide 31) N-((S)-1-((3aS,6R,6aR)-6-isopropyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-4,4-dimethyl-1-oxopentan-2-yl)-4-(4-methylpiperazin-1-yl)benzamide 32) 4-(4-ethylpiperazin-1-yl)-N-((S)-1-((3aS,6R,6aR)-6-isopropyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-4,4-dimethyl-1-oxopentan-2-yl)benzamide 33) N-((S)-1-((3aS,6R,6aR)-6-isopropyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-4,4-dimethyl-1-oxopentan-2-yl)-4-(4-propylpiperazin-1-yl)benzamide 34) N-((S)-1-((3aS,6R,6aR)-6-tert-butyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-4,4-dimethyl-1-oxopentan-2-yl)-4-(4-methylpiperazin-1-yl)benzamide 35) N-((S)-1-((3aS,6R,6aR)-6-tert-butyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-4,4-dimethyl-1-oxopentan-2-yl)-4-(4-ethylpiperazin-1-yl)benzamide 36) N-((S)-1-((3aS,6R,6aR)-6-tert-butyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-4,4-dimethyl-1-oxopentan-2-yl)-4-(4-propylpiperazin-1-yl)benzamide 37) N-((S)-1-((3aS,6R,6aR)-6-cyclopropyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-4,4-dimethyl-1-oxopentan-2-yl)-4-(4-methylpiperazin-1-yl)benzamide 38) N-((S)-1-((3aS,6R,6aR)-6-cyclopropyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-4,4-dimethyl-1-oxopentan-2-yl)-4-(4-ethylpiperazin-1-yl)benzamide 39) N-((S)-1-((3aS,6R,6aR)-6-cyclopropyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-4,4-dimethyl-1-oxopentan-2-yl)-4-(4-propylpiperazin-1-yl)benzamide 40) N-((S)-1-((3aS,6R,6aR)-6-(difluoromethyl)-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-4,4-dimethyl-1-oxopentan-2-yl)-4-(4-methylpiperazin-1-yl)benzamide 41) N-((S)-1-((3aS,6R,6aR)-6-(difluoromethyl)-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-4,4-dimethyl-1-oxopentan-2-yl)-4-(4-ethylpiperazin-1-yl)benzamide 42) N-((S)-1-((3aS,6R,6aR)-6-(difluoromethyl)-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-4,4-dimethyl-1-oxopentan-2-yl)-4-(4-propylpiperazin-1-yl)benzamide 43) N-((2S,3S)-3-methyl-1-((3aS,6R,6aR)-6-methyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-1-oxopentan-2-yl)-4-(4-methylpiperazin-1-yl)benzamide 44) 4-(4-ethylpiperazin-1-yl)-N-((2S,3S)-3-methyl-1-((3aS,6R,6aR)-6-methyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-1-oxopentan-2-yl)benzamide 45) N-((2S,3S)-3-methyl-1-((3aS,6R,6aR)-6-methyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-1-oxopentan-2-yl)-4-(4-propylpiperazin-1-yl)benzamide 46) N-((2S,3S)-1-((3aS,6R,6aR)-6-ethyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-3-methyl-1-oxopentan-2-yl)-4-(4-methylpiperazin-1-yl)benzamide 47) N-((2S,3S)-1-((3aS,6R,6aR)-6-ethyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-3-methyl-1-oxopentan-2-yl)-4-(4-ethylpiperazin-1-yl)benzamide 48) N-((2S,3S)-1-((3aS,6R,6aR)-6-ethyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-3-methyl-1-oxopentan-2-yl)-4-(4-propylpiperazin-1-yl)benzamide 49) N-((2S,3S)-3-methyl-1-oxo-1-((3aS,6R,6aR)-3-oxo-6-propyldihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)pentan-2-yl)-4-(4-methylpiperazin-1-yl)benzamide 50) 4-(4-ethylpiperazin-1-yl)-N-((2S,3S)-3-methyl-1-oxo-1-((3aS,6R,6aR)-3-oxo-6-propyldihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)pentan-2-yl)benzamide 51) N-((2S,3S)-3-methyl-1-oxo-1-((3aS,6R,6aR)-3-oxo-6-propyldihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)pentan-2-yl)-4-(4-propylpiperazin-1-yl)benzamide 52) N-((2S,3S)-1-((3aS,6R,6aR)-6-isopropyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-3-methyl-1-oxopentan-2-yl)-4-(4-methylpiperazin-1-yl)benzamide 53) 4-(4-ethylpiperazin-1-yl)-N-((2S,3S)-1-((3aS,6R,6aR)-6-isopropyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-3-methyl-1-oxopentan-2-yl)benzamide 54) N-((2S,3S)-1-((3aS,6R,6aR)-6-isopropyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-3-methyl-1-oxopentan-2-yl)-4-(4-propylpiperazin-1-yl)benzamide 55) N-((2S,3S)-1-((3aS,6R,6aR)-6-tert-butyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-3-methyl-1-oxopentan-2-yl)-4-(4-methylpiperazin-1-yl)benzamide 56) N-((2S,3S))-1-((3aS,6R,6aR)-6-tert-butyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-3-methyl-1-oxopentan-2-yl)-4-(4-ethylpiperazin-1-yl)benzamide 57) N-((2S,3S))-1-((3aS,6R,6aR)-6-tert-butyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-3-methyl-1-oxopentan-2-yl)-4-(4-propylpiperazin-1-yl)benzamide 58) N-((2S,3S)-1-((3aS,6R,6aR)-6-cyclopropyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-3-methyl-1-oxopentan-2-yl)-4-(4-methylpiperazin-1-yl)benzamide 59) N-((2S,3S)-1-((3aS,6R,6aR)-6-cyclopropyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-3-methyl-1-oxopentan-2-yl)-4-(4-ethylpiperazin-1-yl)benzamide 60) N-((2S,3S)-1-((3aS,6R,6aR)-6-cyclopropyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-3-methyl-1-oxopentan-2-yl)-4-(4-propylpiperazin-1-yl)benzamide 61) N-((2S,3S)-1-((3aS,6R,6aR)-6-(difluoromethyl)-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-3-methyl-1-oxopentan-2-yl)-4-(4-methylpiperazin-1-yl)benzamide 62) N-((2S,3S)-1-((3aS,6R,6aR)-6-(difluoromethyl)-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-3-methyl-1-oxopentan-2-yl)-4-(4-ethylpiperazin-1-yl)benzamide 63) N-((2S,3S)-1-((3aS,6R,6aR)-6-(difluoromethyl)-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-3-methyl-1-oxopentan-2-yl)-4-(4-propylpiperazin-1-yl)benzamide 64) N-((S)-3,3-dimethyl-1-((3aS,6R,6aR)-6-methyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-1-oxopentan-2-yl)-4-(4-methylpiperazin-1-yl)benzamide 65) N-((S)-3,3-dimethyl-1-((3aS,6R,6aR)-6-methyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-1-oxopentan-2-yl)-4-(4-ethylpiperazin-1-yl)benzamide 66) N-((S)-3,3-dimethyl-1-((3aS,6R,6aR)-6-methyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-1-oxopentan-2-yl)-4-(4-propylpiperazin-1-yl)benzamide 67) N-((S)-1-((3aS,6R,6aR)-6-ethyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-3,3-dimethyl-1-oxopentan-2-yl)-4-(4-methylpiperazin-1-yl)benzamide 68) N-((S)-1-((3aS,6R,6aR)-6-ethyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-3,3-dimethyl-1-oxopentan-2-yl)-4-(4-ethylpiperazin-1-yl)benzamide 69) N-((S)-1-((3aS,6R,6aR)-6-ethyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-3,3-dimethyl-1-oxopentan-2-yl)-4-(4-propylpiperazin-1-yl)benzamide 70) N-((S)-3,3-dimethyl-1-oxo-1-((3aS,6R,6aR)-3-oxo-6-propyldihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)pentan-2-yl)-4-(4-methylpiperazin-1-yl)benzamide 71) N-((S)-3,3-dimethyl-1-oxo-1-((3aS,6R,6aR)-3-oxo-6-propyldihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)pentan-2-yl)-4-(4-ethylpiperazin-1-yl)benzamide 72) N-((S)-3,3-dimethyl-1-oxo-1-((3aS,6R,6aR)-3-oxo-6-propyldihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)pentan-2-yl)-4-(4-propylpiperazin-1-yl)benzamide 73) N-((S)-1-((3aS,6R,6aR)-6-isopropyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-3,3-dimethyl-1-oxopentan-2-yl)-4-(4-methylpiperazin-1-yl)benzamide 74) 4-(4-ethylpiperazin-1-yl)-N-((S)-1-((3aS,6R,6aR)-6-isopropyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-3,3-dimethyl-1-oxopentan-2-yl)benzamide 75) N-((S)-1-((3aS,6R,6aR)-6-isopropyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-3,3-dimethyl-1-oxopentan-2-yl)-4-(4-propylpiperazin-1-yl)benzamide 76) N-((S)-1-((3aS,6R,6aR)-6-tert-butyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-3,3-dimethyl-1-oxopentan-2-yl)-4-(4-methylpiperazin-1-yl)benzamide 77) N-((S)-1-((3aS,6R,6aR)-6-tert-butyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-3,3-dimethyl-1-oxopentan-2-yl)-4-(4-ethylpiperazin-1-yl)benzamide 78) N-((S)-1-((3aS,6R,6aR)-6-tert-butyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-3,3-dimethyl-1-oxopentan-2-yl)-4-(4-propylpiperazin-1-yl)benzamide 79) N-((S)-1-((3aS,6R,6aR)-6-cyclopropyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-3,3-dimethyl-1-oxopentan-2-yl)-4-(4-methylpiperazin-1-yl)benzamide 80) N-((S)-1-((3aS,6R,6aR)-6-cyclopropyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-3,3-dimethyl-1-oxopentan-2-yl)-4-(4-ethylpiperazin-1-yl)benzamide 81) N-((S)-1-((3aS,6R,6aR)-6-cyclopropyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-3,3-dimethyl-1-oxopentan-2-yl)-4-(4-propylpiperazin-1-yl)benzamide 82) N-((S)-1-((3aS,6R,6aR)-6-(difluoromethyl)-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-3,3-dimethyl-1-oxopentan-2-yl)-4-(4-methylpiperazin-1-yl)benzamide 83) N-((S)-1-((3aS,6R,6aR)-6-(difluoromethyl)-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-3,3-dimethyl-1-oxopentan-2-yl)-4-(4-ethylpiperazin-1-yl)benzamide 84) N-((S)-1-((3aS,6R,6aR)-6-(difluoromethyl)-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-3,3-dimethyl-1-oxopentan-2-yl)-4-(4-propylpiperazin-1-yl)benzamide 85) N-((S)-1-cyclopentyl-2-((3aS,6R,6aR)-6-methyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-2-oxoethyl)-4-(4-methylpiperazin-1-yl)benzamide 86) N-((S)-1-cyclopentyl-2-((3aS,6R,6aR)-6-methyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-2-oxoethyl)-4-(4-ethylpiperazin-1-yl)benzamide 87) N-((S)-1-cyclopentyl-2-((3aS,6R,6aR)-6-methyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-2-oxoethyl)-4-(4-propylpiperazin-1-yl)benzamide 88) N-((S)-1-cyclopentyl-2-((3aS,6R,6aR)-6-ethyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-2-oxoethyl)-4-(4-methylpiperazin-1-yl)benzamide 89) N-((S)-1-cyclopentyl-2-((3aS,6R,6aR)-6-ethyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-2-oxoethyl)-4-(4-ethylpiperazin-1-yl)benzamide 90) N-((S)-1-cyclopentyl-2-((3aS,6R,6aR)-6-ethyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-2-oxoethyl)-4-(4-propylpiperazin-1-yl)benzamide 91) N-((S)-1-cyclopentyl-2-oxo-2-((3aS,6R,6aR)-3-oxo-6-propyldihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)ethyl)-4-(4-methylpiperazin-1-yl)benzamide 92) N-((S)-1-cyclopentyl-2-oxo-2-((3aS,6R,6aR)-3-oxo-6-propyldihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)ethyl)-4-(4-ethylpiperazin-1-yl)benzamide 93) N-((S)-1-cyclopentyl-2-oxo-2-((3aS,6R,6aR)-3-oxo-6-propyldihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)ethyl)-4-(4-propylpiperazin-1-yl)benzamide 94) N-((S)-1-cyclopentyl-2-((3aS,6R,6aR)-6-isopropyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-2-oxoethyl)-4-(4-methylpiperazin-1-yl)benzamide 95) N-((S)-1-cyclopentyl-2-((3aS,6R,6aR)-6-isopropyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-2-oxoethyl)-4-(4-ethylpiperazin-1-yl)benzamide 96) N-((S)-1-cyclopentyl-2-((3aS,6R,6aR)-6-isopropyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-2-oxoethyl)-4-(4-propylpiperazin-1-yl)benzamide 97) N-((S)-2-((3aS,6R,6aR)-6-tert-butyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-1-cyclopentyl-2-oxoethyl)-4-(4-methylpiperazin-1-yl)benzamide 98) N-((S)-2-((3aS,6R,6aR)-6-tert-butyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-1-cyclopentyl-2-oxoethyl)-4-(4-ethylpiperazin-1-yl)benzamide 99) N-((S)-2-((3aS,6R,6aR)-6-tert-butyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-1-cyclopentyl-2-oxoethyl)-4-(4-propylpiperazin-1-yl)benzamide 100) N-((S)-1-cyclopentyl-2-((3aS,6R,6aR)-6-cyclopropyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-2-oxoethyl)-4-(4-methylpiperazin-1-yl)benzamide 101) N-((S)-1-cyclopentyl-2-((3aS,6R,6aR)-6-cyclopropyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-2-oxoethyl)-4-(4-ethylpiperazin-1-yl)benzamide 102) N-((S)-1-cyclopentyl-2-((3aS,6R,6aR)-6-cyclopropyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-2-oxoethyl)-4-(4-propylpiperazin-1-yl)benzamide 103) N-((S)-1-cyclopentyl-2-((3aS,6R,6aR)-6-(difluoromethyl)-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-2-oxoethyl)-4-(4-methylpiperazin-1-yl)benzamide 104) N-((S)-1-cyclopentyl-2-((3aS,6R,6aR)-6-(difluoromethyl)-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-2-oxoethyl)-4-(4-ethylpiperazin-1-yl)benzamide 105) N-((S)-1-cyclopentyl-2-((3aS,6R,6aR)-6-(difluoromethyl)-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-2-oxoethyl)-4-(4-propylpiperazin-1-yl)benzamide 106) N-((S)-1-cyclohexyl-2-((3aS,6R,6aR)-6-methyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-2-oxoethyl)-4-(4-methylpiperazin-1-yl)benzamide 107) N-((S)-1-cyclohexyl-2-((3aS,6R,6aR)-6-methyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-2-oxoethyl)-4-(4-ethylpiperazin-1-yl)benzamide 108) N-((S)-1-cyclohexyl-2-((3aS,6R,6aR)-6-methyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-2-oxoethyl)-4-(4-propylpiperazin-1-yl)benzamide 109) N-((S)-1-cyclopentyl-2-((3aS,6R,6aR)-6-ethyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-2-oxoethyl)-4-(4-methylpiperazin-1-yl)benzamide 110) N-((S)-1-cyclohexyl-2-((3aS,6R,6aR)-6-ethyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-2-oxoethyl)-4-(4-ethylpiperazin-1-yl)benzamide 111) N-((S)-1-cyclohexyl-2-((3aS,6R,6aR)-6-ethyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-2-oxoethyl)-4-(4-propylpiperazin-1-yl)benzamide 112) N-((S)-1-cyclohexyl-2-oxo-2-((3aS,6R,6aR)-3-oxo-6-propyldihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl) ethyl)-4-(4-methylpiperazin-1-yl)benzamide 113) N-((S)-1-cyclohexyl-2-oxo-2-((3aS,6R,6aR)-3-oxo-6-propyldihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl) ethyl)-4-(4-ethylpiperazin-1-yl)benzamide 114) N-((S)-1-cyclohexyl-2-oxo-2-((3aS,6R,6aR)-3-oxo-6-propyldihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl) ethyl)-4-(4-propylpiperazin-1-yl)benzamide 115) N-((S)-1-cyclohexyl-2-((3aS,6R,6aR)-6-isopropyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-2-oxoethyl)-4-(4-methylpiperazin-1-yl)benzamide 116) N-((S)-1-cyclohexyl-2-((3aS,6R,6aR)-6-isopropyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-2-oxoethyl)-4-(4-ethylpiperazin-1-yl)benzamide 117) N-((S)-1-cyclohexyl-2-((3aS,6R,6aR)-6-isopropyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-2-oxoethyl)-4-(4-propylpiperazin-1-yl)benzamide 118) N-((S)-2-((3aS,6R,6aR)-6-tert-butyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-1-cyclo hexyl-2-oxoethyl)-4-(4-methylpiperazin-1-yl)benzamide 119) N-((S)-2-((3aS,6R,6aR)-6-tert-butyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-1-cyclo hexyl-2-oxoethyl)-4-(4-ethylpiperazin-1-yl)benzamide 120) N-((S)-2-((3aS,6R,6aR)-6-tert-butyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-1-cyclo hexyl-2-oxoethyl)-4-(4-propylpiperazin-1-yl)benzamide 121) N-((S)-1-cyclohexyl-2-((3aS,6R,6aR)-6-cyclopropyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-2-oxoethyl)-4-(4-methylpiperazin-1-yl)benzamide 122) N-((S)-1-cyclohexyl-2-((3aS,6R,6aR)-6-cyclopropyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-2-oxoethyl)-4-(4-ethylpiperazin-1-yl)benzamide 123) N-((S)-1-cyclohexyl-2-((3aS,6R,6aR)-6-cyclopropyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-2-oxoethyl)-4-(4-propylpiperazin-1-yl)benzamide 124) N-((S)-1-cyclohexyl-2-((3aS,6R,6aR)-6-(difluoromethyl)-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-2-oxoethyl)-4-(4-methylpiperazin-1-yl)benzamide 125) N-((S)-1-cyclohexyl-2-((3aS,6R,6aR)-6-(difluoromethyl)-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-2-oxoethyl)-4-(4-ethylpiperazin-1-yl)benzamide 126) N-((S)-1-cyclohexyl-2-((3aS,6R,6aR)-6-(difluoromethyl)-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-2-oxoethyl)-4-(4-propylpiperazin-1-yl)benzamide 127) N-((S)-4-methyl-1-((3aS,6S,6aR)-6-methyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-1-oxopentan-2-yl)-4-(4-methylpiperazin-1-yl)benzamide 128) 4-(4-ethylpiperazin-1-yl)-N-((S)-4-methyl-1-((3aS,6S,6aR)-6-methyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-1-oxopentan-2-yl)benzamide 129) N-((S)-4-methyl-1-((3aS,6S,6aR)-6-methyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-1-oxopentan-2-yl)-4-(4-propylpiperazin-1-yl)benzamide 130) N-((S)-1-((3aS,6S,6aR)-6-ethyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-4-methyl-1-oxopentan-2-yl)-4-(4-methylpiperazin-1-yl)benzamide 131) N-((S)-1-((3aS,6S,6aR)-6-ethyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-4-methyl-1-oxopentan-2-yl)-4-(4-ethylpiperazin-1-yl)benzamide 132) N-((S)-1-((3aS,6S,6aR)-6-ethyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-4-methyl-1-oxopentan-2-yl)-4-(4-propylpiperazin-1-yl)benzamide 133) N-((S)-4-methyl-1-oxo-1-((3aS,6S,6aR)-3-oxo-6-propyldihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)pentan-2-yl)-4-(4-methylpiperazin-1-yl)benzamide 134) 4-(4-ethylpiperazin-1-yl)-N-((S)-4-methyl-1-oxo-1-((3aS,6S,6aR)-3-oxo-6-propyldihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)pentan-2-yl)benzamide 135) N-((S)-4-methyl-1-oxo-1-((3aS,6S,6aR)-3-oxo-6-propyldihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)pentan-2-yl)-4-(4-propylpiperazin-1-yl)benzamide 136) N-((S)-1-((3aS,6S,6aR)-6-isopropyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-4-methyl-1-oxopentan-2-yl)-4-(4-methylpiperazin-1-yl)benzamide 137) N-((S)-1-((3aS,6S,6aR)-6-isopropyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-4-methyl-1-oxopentan-2-yl)-4-(4-ethylpiperazin-1-yl)benzamide 138) N-((S)-1-((3aS,6S,6aR)-6-isopropyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-4-methyl-1-oxopentan-2-yl)-4-(4-propylpiperazin-1-yl)benzamide 139) N-((S)-1-((3aS,6S,6aR)-6-tert-butyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-4-methyl-1-oxopentan-2-yl)-4-(4-methylpiperazin-1-yl)benzamide 140) N-((S)-1-((3aS,6S,6aR)-6-tert-butyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-4-methyl-1-oxopentan-2-yl)-4-(4-ethylpiperazin-1-yl)benzamide 141) N-((S)-1-((3aS,6S,6aR)-6-tert-butyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-4-methyl-1-oxopentan-2-yl)-4-(4-propylpiperazin-1-yl)benzamide 142) N-((S)-1-((3aS,6S,6aR)-6-cyclopropyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-4-methyl-1-oxopentan-2-yl)-4-(4-methylpiperazin-1-yl)benzamide 143) N-((S)-1-((3aS,6S,6aR)-6-cyclopropyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-4-methyl-1-oxopentan-2-yl)-4-(4-ethylpiperazin-1-yl)benzamide 144) N-((S)-1-((3aS,6S,6aR)-6-cyclopropyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-4-methyl-1-oxopentan-2-yl)-4-(4-propylpiperazin-1-yl)benzamide 145) N-((S)-1-((3aS,6S,6aR)-6-(difluoromethyl)-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-4-methyl-1-oxopentan-2-yl)-4-(4-methylpiperazin-1-yl)benzamide 146) N-((S)-1-((3aS,6S,6aR)-6-(difluoromethyl)-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-4-methyl-1-oxopentan-2-yl)-4-(4-ethylpiperazin-1-yl)benzamide 147) N-((S)-1-((3aS,6S6aR)-6-(difluoromethyl)-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-4-methyl-1-oxopentan-2-yl)-4-(4-propylpiperazin-1-yl)benzamide 148) N-((S)-4,4-dimethyl-1-((3aS,6S,6aR)-6-methyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-1-oxopentan-2-yl)-4-(4-methylpiperazin-1-yl)benzamide 149) N-((S)-4,4-dimethyl-1-((3aS,6S,6aR)-6-methyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-1-oxopentan-2-yl)-4-(4-ethylpiperazin-1-yl)benzamide 150) N-((S)-4,4-dimethyl-1-((3aS,6S,6aR)-6-methyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-1-oxopentan-2-yl)-4-(4-propylpiperazin-1-yl)benzamide 151) N-((S)-1-((3aS,6S,6aR)-6-ethyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-4,4-dimethyl-1-oxopentan-2-yl)-4-(4-methylpiperazin-1-yl)benzamide 152) N-((S)-1-((3aS,6S,6aR)-6-ethyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-4,4-dimethyl-1-oxopentan-2-yl)-4-(4-ethylpiperazin-1-yl)benzamide 153) N-((S)-1-((3aS,6R,6aR)-6-ethyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-4,4-dimethyl-1-oxopentan-2-yl)-4-(4-propylpiperazin-1-yl)benzamide 154) N-((S)-4,4-dimethyl-1-oxo-1-((3aS,6S,6aR)-3-oxo-6-propyldihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)pentan-2-yl)-4-(4-methylpiperazin-1-yl)benzamide 155) N-((S)-4,4-dimethyl-1-oxo-1-((3aS,6S,6aR)-3-oxo-6-propyldihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)pentan-2-yl)-4-(4-ethylpiperazin-1-yl)benzamide 156) N-((S)-4,4-dimethyl-1-oxo-1-((3aS,6S,6aR)-3-oxo-6-propyldihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)pentan-2-yl)-4-(4-propylpiperazin-1-yl)benzamide 157) N-((S)-1-((3aS,6S,6aR)-6-isopropyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-4,4-dimethyl-1-oxopentan-2-yl)-4-(4-methylpiperazin-1-yl)benzamide 158) 4-(4-ethylpiperazin-1-yl)-N-((S)-1-((3aS,6S,6aR)-6-isopropyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-4,4-dimethyl-1-oxopentan-2-yl)benzamide 159) N-((S)-1-((3aS,6S,6aR)-6-isopropyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-4,4-dimethyl-1-oxopentan-2-yl)-4-(4-propylpiperazin-1-yl)benzamide 160) N-((S)-1-((3aS,6S,6aR)-6-tert-butyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-4,4-dimethyl-1-oxopentan-2-yl)-4-(4-methylpiperazin-1-yl)benzamide 161) N-((S)-1-((3aS,6S,6aR)-6-tert-butyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-4,4-dimethyl-1-oxopentan-2-yl)-4-(4-ethylpiperazin-1-yl)benzamide 162) N-((S)-1-((3aS,6S,6aR)-6-tert-butyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-4,4-dimethyl-1-oxopentan-2-yl)-4-(4-propylpiperazin-1-yl)benzamide 163) N-((S)-1-((3aS,6S,6aR)-6-cyclopropyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-4,4-dimethyl-1-oxopentan-2-yl)-4-(4-methylpiperazin-1-yl)benzamide 164) N-((S)-1-((3aS,6S,6aR)-6-cyclopropyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-4,4-dimethyl-1-oxopentan-2-yl)-4-(4-ethylpiperazin-1-yl)benzamide 165) N-((S)-1-((3aS,6S,6aR)-6-cyclopropyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-4,4-dimethyl-1-oxopentan-2-yl)-4-(4-propylpiperazin-1-yl)benzamide 166) N-((S)-1-((3aS,6S,6aR)-6-(difluoromethyl)-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-4,4-dimethyl-1-oxopentan-2-yl)-4-(4-methylpiperazin-1-yl)benzamide 167) N-((S)-1-((3aS,6S,6aR)-6-(difluoromethyl)-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-4,4-dimethyl-1-oxopentan-2-yl)-4-(4-ethylpiperazin-1-yl)benzamide 168) N-((S)-1-((3aS,6S,6aR)-6-(difluoromethyl)-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-4,4-dimethyl-1-oxopentan-2-yl)-4-(4-propylpiperazin-1-yl)benzamide 169) N-((2S,3S)-3-methyl-1-((3aS,6S,6aR)-6-methyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-1-oxopentan-2-yl)-4-(4-methylpiperazin-1-yl)benzamide 170) 4-(4-ethylpiperazin-1-yl)-N-((2S,3S)-3-methyl-1-((3aS,6S,6aR)-6-methyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-1-oxopentan-2-yl)benzamide 171) N-((2S,3S)-3-methyl-1-((3aS,6S,6aR)-6-methyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-1-oxopentan-2-yl)-4-(4-propylpiperazin-1-yl)benzamide 172) N-((2S,3S)-1-((3aS,6S,6aR)-6-ethyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-3-methyl-1-oxopentan-2-yl)-4-(4-methylpiperazin-1-yl)benzamide 173) N-((2S,3S)-1-((3aS,6S,6aR)-6-ethyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-3-methyl-1-oxopentan-2-yl)-4-(4-ethylpiperazin-1-yl)benzamide 174) N-((2S,3S)-1-((3aS,6S,6aR)-6-ethyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-3-methyl-1-oxopentan-2-yl)-4-(4-propylpiperazin-1-yl)benzamide 175) N-((2S,3S)-3-methyl-1-oxo-1-((3aS,6S,6aR)-3-oxo-6-propyldihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)pentan-2-yl)-4-(4-methylpiperazin-1-yl)benzamide 176) 4-(4-ethylpiperazin-1-yl)-N-((2S,3S)-3-methyl-1-oxo-1-((3aS,6S,6aR)-3-oxo-6-propyldihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)pentan-2-yl)benzamide 177) N-((2S,3S)-3-methyl-1-oxo-1-((3aS,6S,6aR)-3-oxo-6-propyldihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)pentan-2-yl)-4-(4-propylpiperazin-1-yl)benzamide 178) N-((2S,3S)-1-((3aS,6S,6aR)-6-isopropyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-3-methyl-1-oxopentan-2-yl)-4-(4-methylpiperazin-1-yl)benzamide 179) 4-(4-ethylpiperazin-1-yl)-N-((2S,3S)-1-((3aS,6S,6aR)-6-isopropyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-3-methyl-1-oxopentan-2-yl)benzamide 180) N-((2S,3S)-1-((3aS,6S,6aR)-6-isopropyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-3-methyl-1-oxopentan-2-yl)-4-(4-propylpiperazin-1-yl)benzamide 181) N-((2S,3S)-1-((3aS,6S,6aR)-6-tert-butyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-3-methyl-1-oxopentan-2-yl)-4-(4-methylpiperazin-1-yl)benzamide 182) N-((2S,3S))-1-((3aS,6S,6aR)-6-tert-butyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-3-methyl-1-oxopentan-2-yl)-4-(4-ethylpiperazin-1-yl)benzamide 183) N-((2S,3S))-1-((3aS,6S,6aR)-6-tert-butyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-3-methyl-1-oxopentan-2-yl)-4-(4-propylpiperazin-1-yl)benzamide 184) N-((2S,3S)-1-((3aS,6S,6aR)-6-cyclopropyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-3-methyl-1-oxopentan-2-yl)-4-(4-methylpiperazin-1-yl)benzamide 185) N-((2S,3S)-1-((3aS,6S,6aR)-6-cyclopropyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-3-methyl-1-oxopentan-2-yl)-4-(4-ethylpiperazin-1-yl)benzamide 186) N-((2S,3S)-1-((3aS,6S,6aR)-6-cyclopropyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-3-methyl-1-oxopentan-2-yl)-4-(4-propylpiperazin-1-yl)benzamide 187) N-((2S,3S)-1-((3aS,6S,6aR)-6-(difluoromethyl)-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-3-methyl-1-oxopentan-2-yl)-4-(4-methylpiperazin-1-yl)benzamide 188) N-((2S,3S)-1-((3aS,6S,6aR)-6-(difluoromethyl)-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-3-methyl-1-oxopentan-2-yl)-4-(4-ethylpiperazin-1-yl)benzamide 189) N-((2S,3S)-1-((3aS,6S,6aR)-6-(difluoromethyl)-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-3-methyl-1-oxopentan-2-yl)-4-(4-propylpiperazin-1-yl)benzamide 190) N-((S)-3,3-dimethyl-1-((3aS,6S,6aR)-6-methyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-1-oxopentan-2-yl)-4-(4-methylpiperazin-1-yl)benzamide 191) N-((S)-3,3-dimethyl-1-((3aS,6S,6aR)-6-methyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-1-oxopentan-2-yl)-4-(4-ethylpiperazin-1-yl)benzamide 192) N-((S)-3,3-dimethyl-1-((3aS,6S,6aR)-6-methyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-1-oxopentan-2-yl)-4-(4-propylpiperazin-1-yl)benzamide 193) N-((S)-1-((3aS,6S,6aR)-6-ethyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-3,3-dimethyl-1-oxopentan-2-yl)-4-(4-methylpiperazin-1-yl)benzamide 194) N-((S)-1-((3aS,6S,6aR)-6-ethyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-3,3-dimethyl-1-oxopentan-2-yl)-4-(4-ethylpiperazin-1-yl)benzamide 195) N-((S)-1-((3aS,6S,6aR)-6-ethyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-3,3-dimethyl-1-oxopentan-2-yl)-4-(4-propylpiperazin-1-yl)benzamide 196) N-((S)-3,3-dimethyl-1-oxo-1-((3aS,6S,6aR)-3-oxo-6-propyldihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)pentan-2-yl)-4-(4-methylpiperazin-1-yl)benzamide 197) N-((S)-3,3-dimethyl-1-oxo-1-((3aS,6S,6aR)-3-oxo-6-propyldihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)pentan-2-yl)-4-(4-ethylpiperazin-1-yl)benzamide 198) N-((S)-3,3-dimethyl-1-oxo-1-((3aS,6S,6aR)-3-oxo-6-propyldihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)pentan-2-yl)-4-(4-propylpiperazin-1-yl)benzamide 199) N-((S)-1-((3aS,6S,6aR)-6-isopropyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-3,3-dimethyl-1-oxopentan-2-yl)-4-(4-methylpiperazin-1-yl)benzamide 200) 4-(4-ethylpiperazin-1-yl)-N-((S)-1-((3aS,6S,6aR)-6-isopropyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-3,3-dimethyl-1-oxopentan-2-yl)benzamide 201) N-((S)-1-((3aS,6S,6aR)-6-isopropyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-3,3-dimethyl-1-oxopentan-2-yl)-4-(4-propylpiperazin-1-yl)benzamide 202) N-((S)-1-((3aS,6S,6aR)-6-tert-butyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-3,3-dimethyl-1-oxopentan-2-yl)-4-(4-methylpiperazin-1-yl)benzamide 203) N-((S)-1-((3aS,6S,6aR)-6-tert-butyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-3,3-dimethyl-1-oxopentan-2-yl)-4-(4-ethylpiperazin-1-yl)benzamide 204) N-((S)-1-((3aS,6S,6aR)-6-tert-butyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-3,3-dimethyl-1-oxopentan-2-yl)-4-(4-propylpiperazin-1-yl)benzamide 205) N-((S)-1-((3aS,6S,6aR)-6-cyclopropyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-3,3-dimethyl-1-oxopentan-2-yl)-4-(4-methylpiperazin-1-yl)benzamide 206) N-((S)-1-((3aS,6S,6aR)-6-cyclopropyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-3,3-dimethyl-1-oxopentan-2-yl)-4-(4-ethylpiperazin-1-yl)benzamide 207) N-((S)-1-((3aS,6S,6aR)-6-cyclopropyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-3,3-dimethyl-1-oxopentan-2-yl)-4-(4-propylpiperazin-1-yl)benzamide 208) N-((S)-1-((3aS,6S,6aR)-6-(difluoromethyl)-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-3,3-dimethyl-1-oxopentan-2-yl)-4-(4-methylpiperazin-1-yl)benzamide 209) N-((S)-1-((3aS,6S,6aR)-6-(difluoromethyl)-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-3,3-dimethyl-1-oxopentan-2-yl)-4-(4-ethylpiperazin-1-yl)benzamide 210) N-((S)-1-((3aS,6S,6aR)-6-(difluoromethyl)-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-3,3-dimethyl-1-oxopentan-2-yl)-4-(4-propylpiperazin-1-yl)benzamide 211) N-((S)-1-cyclopentyl-2-((3aS,6S,6aR)-6-methyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-2-oxoethyl)-4-(4-methylpiperazin-1-yl)benzamide 212) N-((S)-1-cyclopentyl-2-((3aS,6S,6aR)-6-methyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-2-oxoethyl)-4-(4-ethylpiperazin-1-yl)benzamide 213) N-((S)-1-cyclopentyl-2-((3aS,6S,6aR)-6-methyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-2-oxoethyl)-4-(4-propylpiperazin-1-yl)benzamide 214) N-((S)-1-cyclopentyl-2-((3aS,6S,6aR)-6-ethyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-2-oxoethyl)-4-(4-methylpiperazin-1-yl)benzamide 215) N-((S)-1-cyclopentyl-2-((3aS,6S,6aR)-6-ethyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-2-oxoethyl)-4-(4-ethylpiperazin-1-yl)benzamide 216) N-((S)-1-cyclopentyl-2-((3aS,6S,6aR)-6-ethyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-2-oxoethyl)-4-(4-propylpiperazin-1-yl)benzamide 217) N-((S)-1-cyclopentyl-2-oxo-2-((3aS,6S,6aR)-3-oxo-6-propyldihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)ethyl)-4-(4-methylpiperazin-1-yl)benzamide 218) N-((S)-1-cyclopentyl-2-oxo-2-((3aS,6S,6aR)-3-oxo-6-propyldihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)ethyl)-4-(4-ethylpiperazin-1-yl)benzamide 219) N-((S)-1-cyclopentyl-2-oxo-2-((3aS,6S,6aR)-3-oxo-6-propyldihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)ethyl)-4-(4-propylpiperazin-1-yl)benzamide 220) N-((S)-1-cyclopentyl-2-((3aS,6S,6aR)-6-isopropyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-2-oxoethyl)-4-(4-methylpiperazin-1-yl)benzamide 221) N-((S)-1-cyclopentyl-2-((3aS,6S,6aR)-6-isopropyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-2-oxoethyl)-4-(4-ethylpiperazin-1-yl)benzamide 222) N-((S)-1-cyclopentyl-2-((3aS,6S,6aR)-6-isopropyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-2-oxoethyl)-4-(4-propylpiperazin-1-yl)benzamide 223) N-((S)-2-((3aS,6S,6aR)-6-tert-butyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-1-cyclopentyl-2-oxoethyl)-4-(4-methylpiperazin-1-yl)benzamide 224) N-((S)-2-((3aS,6S,6aR)-6-tert-butyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-1-cyclopentyl-2-oxoethyl)-4-(4-ethylpiperazin-1-yl)benzamide 225) N-((S)-2-((3aS,6S,6aR)-6-tert-butyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-1-cyclopentyl-2-oxoethyl)-4-(4-propylpiperazin-1-yl)benzamide 226) N-((S)-1-cyclopentyl-2-((3aS,6S,6aR)-6-cyclopropyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-2-oxoethyl)-4-(4-methylpiperazin-1-yl)benzamide 227) N-((S)-1-cyclopentyl-2-((3aS,6S,6aR)-6-cyclopropyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-2-oxoethyl)-4-(4-ethylpiperazin-1-yl)benzamide 228) N-((S)-1-cyclopentyl-2-((3aS,6S,6aR)-6-cyclopropyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-2-oxoethyl)-4-(4-propylpiperazin-1-yl)benzamide 229) N-((S)-1-cyclopentyl-2-((3aS,6S,6aR)-6-(difluoromethyl)-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-2-oxoethyl)-4-(4-methylpiperazin-1-yl)benzamide 230) N-((S)-1-cyclopentyl-2-((3aS,6S,6aR)-6-(difluoromethyl)-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-2-oxoethyl)-4-(4-ethylpiperazin-1-yl)benzamide 231) N-((S)-1-cyclopentyl-2-((3aS,6S,6aR)-6-(difluoromethyl)-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-2-oxoethyl)-4-(4-propylpiperazin-1-yl)benzamide 232) N-((S)-1-cyclohexyl-2-((3aS,6S,6aR)-6-methyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-2-oxoethyl)-4-(4-methylpiperazin-1-yl)benzamide 233) N-((S)-1-cyclohexyl-2-((3aS,6S,6aR)-6-methyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-2-oxoethyl)-4-(4-ethylpiperazin-1-yl)benzamide 234) N-((S)-1-cyclohexyl-2-((3aS,6S,6aR)-6-methyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-2-oxoethyl)-4-(4-propylpiperazin-1-yl)benzamide 235) N-((S)-1-cyclopentyl-2-((3aS,6S,6aR)-6-ethyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-2-oxoethyl)-4-(4-methylpiperazin-1-yl)benzamide 236) N-((S)-1-cyclohexyl-2-((3aS,6S,6aR)-6-ethyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-2-oxoethyl)-4-(4-ethylpiperazin-1-yl)benzamide 237) N-((S)-1-cyclohexyl-2-((3aS,6S,6aR)-6-ethyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-2-oxoethyl)-4-(4-propylpiperazin-1-yl)benzamide 238) N-((S)-1-cyclo hexyl-2-oxo-2-((3aS,6S,6aR)-3-oxo-6-propyldihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)ethyl)-4-(4-methylpiperazin-1-yl)benzamide 239) N-((S)-1-cyclo hexyl-2-oxo-2-((3aS,6S,6aR)-3-oxo-6-propyldihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)ethyl)-4-(4-ethylpiperazin-1-yl)benzamide 240) N-((S)-1-cyclo hexyl-2-oxo-2-((3aS,6S,6aR)-3-oxo-6-propyldihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)ethyl)-4-(4-propylpiperazin-1-yl)benzamide 241) N-((S)-1-cyclo hexyl-2-((3aS,6S,6aR)-6-isopropyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-2-oxoethyl)-4-(4-methylpiperazin-1-yl)benzamide 242) N-((S)-1-cyclo hexyl-2-((3aS,6S,6aR)-6-isopropyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-2-oxoethyl)-4-(4-ethylpiperazin-1-yl)benzamide 243) N-((S)-1-cyclo hexyl-2-((3aS,6S,6aR)-6-isopropyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-2-oxoethyl)-4-(4-propylpiperazin-1-yl)benzamide 244) N-((S)-2-((3aS,6S,6aR)-6-tert-butyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-1-cyclo hexyl-2-oxoethyl)-4-(4-methylpiperazin-1-yl)benzamide 245) N-((S)-2-((3aS,6S,6aR)-6-tert-butyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-1-cyclo hexyl-2-oxoethyl)-4-(4-ethylpiperazin-1-yl)benzamide 246) N-((S)-2-((3aS,6S,6aR)-6-tert-butyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-1-cyclo hexyl-2-oxoethyl)-4-(4-propylpiperazin-1-yl)benzamide 247) N-((S)-1-cyclohexyl-2-((3aS,6S,6aR)-6-cyclopropyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-2-oxoethyl)-4-(4-methylpiperazin-1-yl)benzamide 248) N-((S)-1-cyclohexyl-2-((3aS,6S,6aR)-6-cyclopropyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-2-oxoethyl)-4-(4-ethylpiperazin-1-yl)benzamide 249) N-((S)-1-cyclohexyl-2-((3aS,6S,6aR)-6-cyclopropyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-2-oxoethyl)-4-(4-propylpiperazin-1-yl)benzamide 250) N-((S)-1-cyclohexyl-2-((3aS,6S,6aR)-6-(difluoromethyl)-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-2-oxoethyl)-4-(4-methylpiperazin-1-yl)benzamide 251) N-((S)-1-cyclohexyl-2-((3aS,6S,6aR)-6-(difluoromethyl)-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-2-oxoethyl)-4-(4-ethylpiperazin-1-yl)benzamide 252) N-((S)-1-cyclohexyl-2-((3aS,6S,6aR)-6-(difluoromethyl)-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-2-oxoethyl)-4-(4-propylpiperazin-1-yl)benzamide
13 . The method of claim 1 , wherein said compound is selected from the following:
a) N-((S)-4-methyl-1-((3aS,6R,6aR)-6-methyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-1-oxopentan-2-yl)-4-(4-methylpiperazin-1-yl)benzamide b) N-((2S,3S)-3-methyl-1-((3aS,6R,6aR)-6-methyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-1-oxopentan-2-yl)-4-(4-propylpiperazin-1-yl)benzamide c) N-((S)-3,3-dimethyl-1-((3aS,6R,6aR)-6-methyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-1-oxopentan-2-yl)-4-(4-methylpiperazin-1-yl)benzamide d) N-((S)-1-cyclopentyl-2-((3aS,6R,6aR)-6-methyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-2-oxoethyl)-4-(4-methylpiperazin-1-yl)benzamide e) N-((S)-4-methyl-1-((3aS,6S,6aR)-6-methyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-1-oxopentan-2-yl)-4-(4-methylpiperazin-1-yl)benzamide f) N-((S)-3,3-dimethyl-1-((3aS,6S,6aR)-6-methyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-1-oxopentan-2-yl)-4-(4-methylpiperazin-1-yl)benzamide g) N-((S)-1-cyclopentyl-2-((3aS,6S,6aR)-6-methyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-2-oxoethyl)-4-(4-methylpiperazin-1-yl)benzamide h) N-((S)-1-((3aS,6R,6aR)-6-(difluoromethyl)-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-4-methyl-1-oxopentan-2-yl)-4-(4-methylpiperazin-1-yl)benzamide i) N-((S)-1-((3aS,6R,6aR)-6-(difluoromethyl)-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-3,3-dimethyl-1-oxopentan-2-yl)-4-(4-methylpiperazin-1-yl)benzamide j) N-((2S,3S)-1-((3aS,6R,6aR)-6-(difluoromethyl)-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-3-methyl-1-oxopentan-2-yl)-4-(4-methylpiperazin-1-yl)benzamide k) N-((S)-1-cyclopentyl-2-((3aS,6R,6aR)-6-(difluoromethyl)-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-2-oxoethyl)-4-(4-methylpiperazin-1-yl)benzamide l) N-((S)-1-((3aS,6S,6aR)-6-(difluoromethyl)-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-4-methyl-1-oxopentan-2-yl)-4-(4-methylpiperazin-1-yl)benzamide m) N-((S)-1-((3aS,6S,6aR)-6-(difluoromethyl)-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-3,3-dimethyl-1-oxopentan-2-yl)-4-(4-methylpiperazin-1-yl)benzamide n) N-((2S,3S)-1-((3aS,6S,6aR)-6-(difluoromethyl)-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-3-methyl-1-oxopentan-2-yl)-4-(4-methylpiperazin-1-yl)benzamide o) N-((S)-1-cyclopentyl-2-((3aS,6S,6aR)-6-(difluoromethyl)-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-2-oxoethyl)-4-(4-methylpiperazin-1-yl)benzamide p) N-((S)-1-((3aS,6R,6aR)-6-ethyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-3,3-dimethyl-1-oxobutan-2-yl)-4-(4-methylpiperazin-1-yl)benzamide q) N-((S)-1-((3aS,6R,6aR)-6-isopropyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-3,3-dimethyl-1-oxobutan-2-yl)-4-(4-methylpiperazin-1-yl)benzamide r) N-((S)-1-((3aS,6S,6aR)-6-ethyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-3,3-dimethyl-1-oxobutan-2-yl)-4-(4-methylpiperazin-1-yl)benzamide s) N-((S)-1-((3aS,6S,6aR)-6-isopropyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-3,3-dimethyl-1-oxobutan-2-yl)-4-(4-methylpiperazin-1-yl)benzamide t) N-((S)-1-cyclopentyl-2-((3aS,6R,6aR)-6-ethyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-2-oxoethyl)-4-(4-methylpiperazin-1-yl)benzamide u) N-((S)-1-cyclopentyl-2-((3aS,6R,6aR)-6-isopropyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-2-oxoethyl)-4-(4-methylpiperazin-1-yl)benzamide v) N-((S)-1-cyclopentyl-2-((3aS,6S,6aR)-6-ethyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-2-oxoethyl)-4-(4-methylpiperazin-1-yl)benzamide w) N-((S)-1-cyclopentyl-2-((3aS,6S,6aR)-6-isopropyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-2-oxoethyl)-4-(4-methylpiperazin-1-yl)benzamide x) N-((S)-1-cyclopentyl-2-oxo-2-((3aS,6S,6aR)-3-oxo-6-propyldihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)ethyl)-4-(4-methylpiperazin-1-yl)benzamide y) N-((S)-1-cyclopentyl-2-((3aS,6S,6aR)-6-cyclopropyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-2-oxoethyl)-4-(4-methylpiperazin-1-yl)benzamide z) N-((S)-2-((3aS,6S,6aR)-6-benzyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-1-cyclopentyl-2-oxoethyl)-4-(4-methylpiperazin-1-yl)benzamide aa) N-((S)-2-((3aS,6S,6aR)-6-methyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-1-(1-methylcyclopentyl)-2-oxoethyl)-4-(4-methylpiperazin-1-yl)benzamide and bb) N-((S)-2-((3aS,6R,6aR)-6-methyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-1-(1-methylcyclopentyl)-2-oxoethyl)-4-(4-methylpiperazin-1-yl)benzamide.
14 . A method of inhibiting activity of Cathepsin K in a subject, said method comprising administering to said subject a compound according to claim 1 , wherein said subject suffers from a disease selected from the group consisting of: osteoporosis, Paget's disease, Chagas's disease, malaria, gingival diseases, hypercalcemia, metabolic bone disease, diseases involving matrix or cartilage degradation, bone cancer, and bone metastases and associated pain.
15 . The method of claim 14 , wherein said contacting or administering is with a compound of formula Ia:
wherein R 1 , R 2 , R 3 and R 9 are as defined in claim 1 .
16 . The method of claim 14 , wherein said R1 and R2 is H, and the other is selected from methyl, ethyl, propyl, iso-propyl, tert-butyl, cyclopropyl, cyclopropylmethyl, iso-propylmethyl, tert-butylmethyl, CH2OH, CH2OMe, CH2OCH2Ph, CH2Ph, CH2F and CHF2.
17 . The method of claim 14 , wherein one of R1 and R2 is H, and the other is C1-8-alkyl.
18 . The method of claim 14 , wherein one of R1 and R2 is H, and the other is selected from methyl, ethyl, iso-propyl and CHF2.
19 . The method of claim 14 , wherein R3 is selected from tert-butylmethyl, iso-propylmethyl, sec-butyl, tert-butyl, cyclopentyl and cyclohexyl.
20 . The method of claim 14 , wherein R3 is cyclopentyl or tert-butyl.
21 . The method of claim 14 , wherein R4 is C1-8-alkyl
22 . The method of claim 14 , wherein R4 is selected from methyl, ethyl and propyl.
23 . The method of claim 1 , wherein one of R 1 and R 2 is H, and the other is C 2-8 -alkynyl.
24 . The method of claim 1 , wherein R 9 is:
25 . The method of claim 14 , wherein said compound is selected from the following:
1) N-((S)-4-methyl-1-((3aS,6R,6aR)-6-methyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-1-oxopentan-2-yl)-4-(4-methylpiperazin-1-yl)benzamide 2) 4-(4-ethylpiperazin-1-yl)-N-((S)-4-methyl-1-((3aS,6R,6aR)-6-methyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-1-oxopentan-2-yl)benzamide 3) N-((S)-4-methyl-1-((3aS,6R,6aR)-6-methyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-1-oxopentan-2-yl)-4-(4-propylpiperazin-1-yl)benzamide 4) N-((S)-1-((3aS,6R,6aR)-6-ethyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-4-methyl-1-oxopentan-2-yl)-4-(4-methylpiperazin-1-yl)benzamide 5) N-((S)-1-((3aS,6R,6aR)-6-ethyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-4-methyl-1-oxopentan-2-yl)-4-(4-ethylpiperazin-1-yl)benzamide 6) N-((S)-1-((3aS,6R,6aR)-6-ethyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-4-methyl-1-oxopentan-2-yl)-4-(4-propylpiperazin-1-yl)benzamide 7) N-((S)-4-methyl-1-oxo-1-((3aS,6R,6aR)-3-oxo-6-propyldihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)pentan-2-yl)-4-(4-methylpiperazin-1-yl)benzamide 8) 4-(4-ethylpiperazin-1-yl)-N-((S)-4-methyl-1-oxo-1-((3aS,6R,6aR)-3-oxo-6-propyldihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)pentan-2-yl)benzamide 9) N-((S)-4-methyl-1-oxo-1-((3aS,6R,6aR)-3-oxo-6-propyldihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)pentan-2-yl)-4-(4-propylpiperazin-1-yl)benzamide 10) N-((S)-1-((3aS,6R,6aR)-6-isopropyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-4-methyl-1-oxopentan-2-yl)-4-(4-methylpiperazin-1-yl)benzamide 11) N-((S)-1-((3aS,6R,6aR)-6-isopropyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-4-methyl-1-oxopentan-2-yl)-4-(4-ethylpiperazin-1-yl)benzamide 12) N-((S)-1-((3aS,6R,6aR)-6-isopropyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-4-methyl-1-oxopentan-2-yl)-4-(4-propylpiperazin-1-yl)benzamide 13) N-((S)-1-((3aS,6R,6aR)-6-tert-butyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-4-methyl-1-oxopentan-2-yl)-4-(4-methylpiperazin-1-yl)benzamide 14) N-((S)-1-((3aS,6R,6aR)-6-tert-butyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-4-methyl-1-oxopentan-2-yl)-4-(4-ethylpiperazin-1-yl)benzamide 15) N-((S)-1-((3aS,6R,6aR)-6-tert-butyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-4-methyl-1-oxopentan-2-yl)-4-(4-propylpiperazin-1-yl)benzamide 16) N-((S)-1-((3aS,6R,6aR)-6-cyclopropyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-4-methyl-1-oxopentan-2-yl)-4-(4-methylpiperazin-1-yl)benzamide 17) N-((S)-1-((3aS,6R,6aR)-6-cyclopropyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-4-methyl-1-oxopentan-2-yl)-4-(4-ethylpiperazin-1-yl)benzamide 18) N-((S)-1-((3aS,6R,6aR)-6-cyclopropyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-4-methyl-1-oxopentan-2-yl)-4-(4-propylpiperazin-1-yl)benzamide 19) N-((S)-1-((3aS,6R,6aR)-6-(difluoromethyl)-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-4-methyl-1-oxopentan-2-yl)-4-(4-methylpiperazin-1-yl)benzamide 20) N-((S)-1-((3aS,6R,6aR)-6-(difluoromethyl)-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-4-methyl-1-oxopentan-2-yl)-4-(4-ethylpiperazin-1-yl)benzamide 21) N-((S)-1-((3aS,6R,6aR)-6-(difluoromethyl)-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-4-methyl-1-oxopentan-2-yl)-4-(4-propylpiperazin-1-yl)benzamide 22) N-((S)-4,4-dimethyl-1-((3aS,6R,6aR)-6-methyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-1-oxopentan-2-yl)-4-(4-methylpiperazin-1-yl)benzamide 23) N-((S)-4,4-dimethyl-1-((3aS,6R,6aR)-6-methyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-1-oxopentan-2-yl)-4-(4-ethylpiperazin-1-yl)benzamide 24) N-((S)-4,4-dimethyl-1-((3aS,6R,6aR)-6-methyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-1-oxopentan-2-yl)-4-(4-propylpiperazin-1-yl)benzamide 25) N-((S)-1-((3aS,6R,6aR)-6-ethyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-4,4-dimethyl-1-oxopentan-2-yl)-4-(4-methylpiperazin-1-yl)benzamide 26) N-((S)-1-((3aS,6R,6aR)-6-ethyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-4,4-dimethyl-1-oxopentan-2-yl)-4-(4-ethylpiperazin-1-yl)benzamide 27) N-((S)-1-((3aS,6R,6aR)-6-ethyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-4,4-dimethyl-1-oxopentan-2-yl)-4-(4-propylpiperazin-1-yl)benzamide 28) N-((S)-4,4-dimethyl-1-oxo-1-((3aS,6R,6aR)-3-oxo-6-propyldihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)pentan-2-yl)-4-(4-methylpiperazin-1-yl)benzamide 29) N-((S)-4,4-dimethyl-1-oxo-1-((3aS,6R,6aR)-3-oxo-6-propyldihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)pentan-2-yl)-4-(4-ethylpiperazin-1-yl)benzamide 30) N-((S)-4,4-dimethyl-1-oxo-1-((3aS,6R,6aR)-3-oxo-6-propyldihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)pentan-2-yl)-4-(4-propylpiperazin-1-yl)benzamide 31) N-((S)-1-((3aS,6R,6aR)-6-isopropyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-4,4-dimethyl-1-oxopentan-2-yl)-4-(4-methylpiperazin-1-yl)benzamide 32) 4-(4-ethylpiperazin-1-yl)-N-((S)-1-((3aS,6R,6aR)-6-isopropyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-4,4-dimethyl-1-oxopentan-2-yl)benzamide 33) N-((S)-1-((3aS,6R,6aR)-6-isopropyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-4,4-dimethyl-1-oxopentan-2-yl)-4-(4-propylpiperazin-1-yl)benzamide 34) N-((S)-1-((3aS,6R,6aR)-6-tert-butyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-4,4-dimethyl-1-oxopentan-2-yl)-4-(4-methylpiperazin-1-yl)benzamide 35) N-((S)-1-((3aS,6R,6aR)-6-tert-butyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-4,4-dimethyl-1-oxopentan-2-yl)-4-(4-ethylpiperazin-1-yl)benzamide 36) N-((S)-1-((3aS,6R,6aR)-6-tert-butyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-4,4-dimethyl-1-oxopentan-2-yl)-4-(4-propylpiperazin-1-yl)benzamide 37) N-((S)-1-((3aS,6R,6aR)-6-cyclopropyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-4,4-dimethyl-1-oxopentan-2-yl)-4-(4-methylpiperazin-1-yl)benzamide 38) N-((S)-1-((3aS,6R,6aR)-6-cyclopropyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-4,4-dimethyl-1-oxopentan-2-yl)-4-(4-ethylpiperazin-1-yl)benzamide 39) N-((S)-1-((3aS,6R,6aR)-6-cyclopropyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-4,4-dimethyl-1-oxopentan-2-yl)-4-(4-propylpiperazin-1-yl)benzamide 40) N-((S)-1-((3aS,6R,6aR)-6-(difluoromethyl)-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-4,4-dimethyl-1-oxopentan-2-yl)-4-(4-methylpiperazin-1-yl)benzamide 41) N-((S)-1-((3aS,6R,6aR)-6-(difluoromethyl)-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-4,4-dimethyl-1-oxopentan-2-yl)-4-(4-ethylpiperazin-1-yl)benzamide 42) N-((S)-1-((3aS,6R,6aR)-6-(difluoromethyl)-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-4,4-dimethyl-1-oxopentan-2-yl)-4-(4-propylpiperazin-1-yl)benzamide 43) N-((2S,3S)-3-methyl-1-((3aS,6R,6aR)-6-methyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-1-oxopentan-2-yl)-4-(4-methylpiperazin-1-yl)benzamide 44) 4-(4-ethylpiperazin-1-yl)-N-((2S,3S)-3-methyl-1-((3aS,6R,6aR)-6-methyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-1-oxopentan-2-yl)benzamide 45) N-((2S,3S)-3-methyl-1-((3aS,6R,6aR)-6-methyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-1-oxopentan-2-yl)-4-(4-propylpiperazin-1-yl)benzamide 46) N-((2S,3S)-1-((3aS,6R,6aR)-6-ethyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-3-methyl-1-oxopentan-2-yl)-4-(4-methylpiperazin-1-yl)benzamide 47) N-((2S,3S)-1-((3aS,6R,6aR)-6-ethyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-3-methyl-1-oxopentan-2-yl)-4-(4-ethylpiperazin-1-yl)benzamide 48) N-((2S,3S)-1-((3aS,6R,6aR)-6-ethyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-3-methyl-1-oxopentan-2-yl)-4-(4-propylpiperazin-1-yl)benzamide 49) N-((2S,3S)-3-methyl-1-oxo-1-((3aS,6R,6aR)-3-oxo-6-propyldihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)pentan-2-yl)-4-(4-methylpiperazin-1-yl)benzamide 50) 4-(4-ethylpiperazin-1-yl)-N-((2S,3S)-3-methyl-1-oxo-1-((3aS,6R,6aR)-3-oxo-6-propyldihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)pentan-2-yl)benzamide 51) N-((2S,3S)-3-methyl-1-oxo-1-((3aS,6R,6aR)-3-oxo-6-propyldihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)pentan-2-yl)-4-(4-propylpiperazin-1-yl)benzamide 52) N-((2S,3S)-1-((3aS,6R,6aR)-6-isopropyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-3-methyl-1-oxopentan-2-yl)-4-(4-methylpiperazin-1-yl)benzamide 53) 4-(4-ethylpiperazin-1-yl)-N-((2S,3S)-1-((3aS,6R,6aR)-6-isopropyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-3-methyl-1-oxopentan-2-yl)benzamide 54) N-((2S,3S)-1-((3aS,6R,6aR)-6-isopropyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-3-methyl-1-oxopentan-2-yl)-4-(4-propylpiperazin-1-yl)benzamide 55) N-((2S,3S)-1-((3aS,6R,6aR)-6-tert-butyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-3-methyl-1-oxopentan-2-yl)-4-(4-methylpiperazin-1-yl)benzamide 56) N-((2S,3S))-1-((3aS,6R,6aR)-6-tert-butyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-3-methyl-1-oxopentan-2-yl)-4-(4-ethylpiperazin-1-yl)benzamide 57) N-((2S,3S))-1-((3aS,6R,6aR)-6-tert-butyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-3-methyl-1-oxopentan-2-yl)-4-(4-propylpiperazin-1-yl)benzamide 58) N-((2S,3S)-1-((3aS,6R,6aR)-6-cyclopropyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-3-methyl-1-oxopentan-2-yl)-4-(4-methylpiperazin-1-yl)benzamide 59) N-((2S,3S)-1-((3aS,6R,6aR)-6-cyclopropyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-3-methyl-1-oxopentan-2-yl)-4-(4-ethylpiperazin-1-yl)benzamide 60) N-((2S,3S)-1-((3aS,6R,6aR)-6-cyclopropyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-3-methyl-1-oxopentan-2-yl)-4-(4-propylpiperazin-1-yl)benzamide 61) N-((2S,3S)-1-((3aS,6R,6aR)-6-(difluoromethyl)-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-3-methyl-1-oxopentan-2-yl)-4-(4-methylpiperazin-1-yl)benzamide 62) N-((2S,3S)-1-((3aS,6R,6aR)-6-(difluoromethyl)-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-3-methyl-1-oxopentan-2-yl)-4-(4-ethylpiperazin-1-yl)benzamide 63) N-((2S,3S)-1-((3aS,6R,6aR)-6-(difluoromethyl)-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-3-methyl-1-oxopentan-2-yl)-4-(4-propylpiperazin-1-yl)benzamide 64) N-((S)-3,3-dimethyl-1-((3aS,6R,6aR)-6-methyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-1-oxopentan-2-yl)-4-(4-methylpiperazin-1-yl)benzamide 65) N-((S)-3,3-dimethyl-1-((3aS,6R,6aR)-6-methyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-1-oxopentan-2-yl)-4-(4-ethylpiperazin-1-yl)benzamide 66) N-((S)-3,3-dimethyl-1-((3aS,6R,6aR)-6-methyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-1-oxopentan-2-yl)-4-(4-propylpiperazin-1-yl)benzamide 67) N-((S)-1-((3aS,6R,6aR)-6-ethyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6 aH)-yl)-3,3-dimethyl-1-oxopentan-2-yl)-4-(4-methylpiperazin-1-yl)benzamide 68) N-((S)-1-((3aS,6R,6aR)-6-ethyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-3,3-dimethyl-1-oxopentan-2-yl)-4-(4-ethylpiperazin-1-yl)benzamide 69) N-((S)-1-((3aS,6R,6aR)-6-ethyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-3,3-dimethyl-1-oxopentan-2-yl)-4-(4-propylpiperazin-1-yl)benzamide 70) N-((S)-3,3-dimethyl-1-oxo-1-((3aS,6R,6aR)-3-oxo-6-propyldihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)pentan-2-yl)-4-(4-methylpiperazin-1-yl)benzamide 71) N-((S)-3,3-dimethyl-1-oxo-1-((3aS,6R,6aR)-3-oxo-6-propyldihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)pentan-2-yl)-4-(4-ethylpiperazin-1-yl)benzamide 72) N-((S)-3,3-dimethyl-1-oxo-1-((3aS,6R,6aR)-3-oxo-6-propyldihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)pentan-2-yl)-4-(4-propylpiperazin-1-yl)benzamide 73) N-((S)-1-((3aS,6R,6aR)-6-isopropyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-3,3-dimethyl-1-oxopentan-2-yl)-4-(4-methylpiperazin-1-yl)benzamide 74) 4-(4-ethylpiperazin-1-yl)-N-((S)-1-((3aS,6R,6aR)-6-isopropyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-3,3-dimethyl-1-oxopentan-2-yl)benzamide 75) N-((S)-1-((3aS,6R,6aR)-6-isopropyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-3,3-dimethyl-1-oxopentan-2-yl)-4-(4-propylpiperazin-1-yl)benzamide 76) N-((S)-1-((3aS,6R,6aR)-6-tert-butyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-3,3-dimethyl-1-oxopentan-2-yl)-4-(4-methylpiperazin-1-yl)benzamide 77) N-((S)-1-((3aS,6R,6aR)-6-tert-butyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-3,3-dimethyl-1-oxopentan-2-yl)-4-(4-ethylpiperazin-1-yl)benzamide 78) N-((S)-1-((3aS,6R,6aR)-6-tert-butyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-3,3-dimethyl-1-oxopentan-2-yl)-4-(4-propylpiperazin-1-yl)benzamide 79) N-((S)-1-((3aS,6R,6aR)-6-cyclopropyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-3,3-dimethyl-1-oxopentan-2-yl)-4-(4-methylpiperazin-1-yl)benzamide 80) N-((S)-1-((3aS,6R,6aR)-6-cyclopropyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-3,3-dimethyl-1-oxopentan-2-yl)-4-(4-ethylpiperazin-1-yl)benzamide 81) N-((S)-1-((3aS,6R,6aR)-6-cyclopropyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-3,3-dimethyl-1-oxopentan-2-yl)-4-(4-propylpiperazin-1-yl)benzamide 82) N-((S)-1-((3aS,6R,6aR)-6-(difluoromethyl)-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-3,3-dimethyl-1-oxopentan-2-yl)-4-(4-methylpiperazin-1-yl)benzamide 83) N-((S)-1-((3aS,6R,6aR)-6-(difluoromethyl)-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-3,3-dimethyl-1-oxopentan-2-yl)-4-(4-ethylpiperazin-1-yl)benzamide 84) N-((S)-1-((3aS,6R,6aR)-6-(difluoromethyl)-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-3,3-dimethyl-1-oxopentan-2-yl)-4-(4-propylpiperazin-1-yl)benzamide 85) N-((S)-1-cyclopentyl-2-((3aS,6R,6aR)-6-methyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-2-oxoethyl)-4-(4-methylpiperazin-1-yl)benzamide 86) N-((S)-1-cyclopentyl-2-((3aS,6R,6aR)-6-methyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-2-oxoethyl)-4-(4-ethylpiperazin-1-yl)benzamide 87) N-((S)-1-cyclopentyl-2-((3aS,6R,6aR)-6-methyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-2-oxoethyl)-4-(4-propylpiperazin-1-yl)benzamide 88) N-((S)-1-cyclopentyl-2-((3aS,6R,6aR)-6-ethyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-2-oxoethyl)-4-(4-methylpiperazin-1-yl)benzamide 89) N-((S)-1-cyclopentyl-2-((3aS,6R,6aR)-6-ethyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-2-oxoethyl)-4-(4-ethylpiperazin-1-yl)benzamide 90) N-((S)-1-cyclopentyl-2-((3aS,6R,6aR)-6-ethyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-2-oxoethyl)-4-(4-propylpiperazin-1-yl)benzamide 91) N-((S)-1-cyclopentyl-2-oxo-2-((3aS,6R,6aR)-3-oxo-6-propyldihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)ethyl)-4-(4-methylpiperazin-1-yl)benzamide 92) N-((S)-1-cyclopentyl-2-oxo-2-((3aS,6R,6aR)-3-oxo-6-propyldihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)ethyl)-4-(4-ethylpiperazin-1-yl)benzamide 93) N-((S)-1-cyclopentyl-2-oxo-2-((3aS,6R,6aR)-3-oxo-6-propyldihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)ethyl)-4-(4-propylpiperazin-1-yl)benzamide 94) N-((S)-1-cyclopentyl-2-((3aS,6R,6aR)-6-isopropyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-2-oxoethyl)-4-(4-methylpiperazin-1-yl)benzamide 95) N-((S)-1-cyclopentyl-2-((3aS,6R,6aR)-6-isopropyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-2-oxoethyl)-4-(4-ethylpiperazin-1-yl)benzamide 96) N-((S)-1-cyclopentyl-2-((3aS,6R,6aR)-6-isopropyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-2-oxoethyl)-4-(4-propylpiperazin-1-yl)benzamide 97) N-((S)-2-((3aS,6R,6aR)-6-tert-butyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-1-cyclopentyl-2-oxoethyl)-4-(4-methylpiperazin-1-yl)benzamide 98) N-((S)-2-((3aS,6R,6aR)-6-tert-butyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-1-cyclopentyl-2-oxoethyl)-4-(4-ethylpiperazin-1-yl)benzamide 99) N-((S)-2-((3aS,6R,6aR)-6-tert-butyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-1-cyclopentyl-2-oxoethyl)-4-(4-propylpiperazin-1-yl)benzamide 100) N-((S)-1-cyclopentyl-2-((3aS,6R,6aR)-6-cyclopropyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-2-oxoethyl)-4-(4-methylpiperazin-1-yl)benzamide 101) N-((S)-1-cyclopentyl-2-((3aS,6R,6aR)-6-cyclopropyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-2-oxoethyl)-4-(4-ethylpiperazin-1-yl)benzamide 102) N-((S)-1-cyclopentyl-2-((3aS,6R,6aR)-6-cyclopropyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-2-oxoethyl)-4-(4-propylpiperazin-1-yl)benzamide 103) N-((S)-1-cyclopentyl-2-((3aS,6R,6aR)-6-(difluoromethyl)-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-2-oxoethyl)-4-(4-methylpiperazin-1-yl)benzamide 104) N-((S)-1-cyclopentyl-2-((3aS,6R,6aR)-6-(difluoromethyl)-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-2-oxoethyl)-4-(4-ethylpiperazin-1-yl)benzamide 105) N-((S)-1-cyclopentyl-2-((3aS,6R,6aR)-6-(difluoromethyl)-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-2-oxoethyl)-4-(4-propylpiperazin-1-yl)benzamide 106) N-((S)-1-cyclohexyl-2-((3aS,6R,6aR)-6-methyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-2-oxoethyl)-4-(4-methylpiperazin-1-yl)benzamide 107) N-((S)-1-cyclohexyl-2-((3aS,6R,6aR)-6-methyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-2-oxoethyl)-4-(4-ethylpiperazin-1-yl)benzamide 108) N-((S)-1-cyclohexyl-2-((3aS,6R,6aR)-6-methyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-2-oxoethyl)-4-(4-propylpiperazin-1-yl)benzamide 109) N-((S)-1-cyclopentyl-2-((3aS,6R,6aR)-6-ethyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-2-oxoethyl)-4-(4-methylpiperazin-1-yl)benzamide 110) N-((S)-1-cyclohexyl-2-((3aS,6R,6aR)-6-ethyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-2-oxoethyl)-4-(4-ethylpiperazin-1-yl)benzamide 111) N-((S)-1-cyclohexyl-2-((3aS,6R,6aR)-6-ethyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-2-oxoethyl)-4-(4-propylpiperazin-1-yl)benzamide 112) N-((S)-1-cyclohexyl-2-oxo-2-((3aS,6R,6aR)-3-oxo-6-propyldihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl) ethyl)-4-(4-methylpiperazin-1-yl)benzamide 113) N-((S)-1-cyclohexyl-2-oxo-2-((3aS,6R,6aR)-3-oxo-6-propyldihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl) ethyl)-4-(4-ethylpiperazin-1-yl)benzamide 114) N-((S)-1-cyclohexyl-2-oxo-2-((3aS,6R,6aR)-3-oxo-6-propyldihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl) ethyl)-4-(4-propylpiperazin-1-yl)benzamide 115) N-((S)-1-cyclohexyl-2-((3aS,6R,6aR)-6-isopropyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-2-oxoethyl)-4-(4-methylpiperazin-1-yl)benzamide 116) N-((S)-1-cyclohexyl-2-((3aS,6R,6aR)-6-isopropyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-2-oxoethyl)-4-(4-ethylpiperazin-1-yl)benzamide 117) N-((S)-1-cyclohexyl-2-((3aS,6R,6aR)-6-isopropyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-2-oxoethyl)-4-(4-propylpiperazin-1-yl)benzamide 118) N-((S)-2-((3aS,6R,6aR)-6-tert-butyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-1-cyclohexyl-2-oxoethyl)-4-(4-methylpiperazin-1-yl)benzamide 119) N-((S)-2-((3aS,6R,6aR)-6-tert-butyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-1-cyclohexyl-2-oxoethyl)-4-(4-ethylpiperazin-1-yl)benzamide 120) N-((S)-2-((3aS,6R,6aR)-6-tert-butyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-1-cyclohexyl-2-oxoethyl)-4-(4-propylpiperazin-1-yl)benzamide 121) N-((S)-1-cyclohexyl-2-((3aS,6R,6aR)-6-cyclopropyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-2-oxoethyl)-4-(4-methylpiperazin-1-yl)benzamide 122) N-((S)-1-cyclohexyl-2-((3aS,6R,6aR)-6-cyclopropyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-2-oxoethyl)-4-(4-ethylpiperazin-1-yl)benzamide 123) N-((S)-1-cyclohexyl-2-((3aS,6R,6aR)-6-cyclopropyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-2-oxoethyl)-4-(4-propylpiperazin-1-yl)benzamide 124) N-((S)-1-cyclohexyl-2-((3aS,6R,6aR)-6-(difluoromethyl)-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-2-oxoethyl)-4-(4-methylpiperazin-1-yl)benzamide 125) N-((S)-1-cyclohexyl-2-((3aS,6R,6aR)-6-(difluoromethyl)-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-2-oxoethyl)-4-(4-ethylpiperazin-1-yl)benzamide 126) N-((S)-1-cyclohexyl-2-((3aS,6R,6aR)-6-(difluoromethyl)-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-2-oxoethyl)-4-(4-propylpiperazin-1-yl)benzamide 127) N-((S)-4-methyl-1-((3aS,6S,6aR)-6-methyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-1-oxopentan-2-yl)-4-(4-methylpiperazin-1-yl)benzamide 128) 4-(4-ethylpiperazin-1-yl)-N-((S)-4-methyl-1-((3aS,6S,6aR)-6-methyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-1-oxopentan-2-yl)benzamide 129) N-((S)-4-methyl-1-((3aS,6S,6aR)-6-methyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-1-oxopentan-2-yl)-4-(4-propylpiperazin-1-yl)benzamide 130) N-((S)-1-((3aS,6S,6aR)-6-ethyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-4-methyl-1-oxopentan-2-yl)-4-(4-methylpiperazin-1-yl)benzamide 131) N-((S)-1-((3aS,6S,6aR)-6-ethyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-4-methyl-1-oxopentan-2-yl)-4-(4-ethylpiperazin-1-yl)benzamide 132) N-((S)-1-((3aS,6S,6aR)-6-ethyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-4-methyl-1-oxopentan-2-yl)-4-(4-propylpiperazin-1-yl)benzamide 133) N-((S)-4-methyl-1-oxo-1-((3aS,6S,6aR)-3-oxo-6-propyldihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)pentan-2-yl)-4-(4-methylpiperazin-1-yl)benzamide 134) 4-(4-ethylpiperazin-1-yl)-N-((S)-4-methyl-1-oxo-1-((3aS,6S,6aR)-3-oxo-6-propyldihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)pentan-2-yl)benzamide 135) N-((S)-4-methyl-1-oxo-1-((3aS,6S,6aR)-3-oxo-6-propyldihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)pentan-2-yl)-4-(4-propylpiperazin-1-yl)benzamide 136) N-((S)-1-((3aS,6S,6aR)-6-isopropyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-4-methyl-1-oxopentan-2-yl)-4-(4-methylpiperazin-1-yl)benzamide 137) N-((S)-1-((3aS,6S,6aR)-6-isopropyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-4-methyl-1-oxopentan-2-yl)-4-(4-ethylpiperazin-1-yl)benzamide 138) N-((S)-1-((3aS,6S,6aR)-6-isopropyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-4-methyl-1-oxopentan-2-yl)-4-(4-propylpiperazin-1-yl)benzamide 139) N-((S)-1-((3aS,6S,6aR)-6-tert-butyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-4-methyl-1-oxopentan-2-yl)-4-(4-methylpiperazin-1-yl)benzamide 140) N-((S)-1-((3aS,6S,6aR)-6-tert-butyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-4-methyl-1-oxopentan-2-yl)-4-(4-ethylpiperazin-1-yl)benzamide 141) N-((S)-1-((3aS,6S,6aR)-6-tert-butyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-4-methyl-1-oxopentan-2-yl)-4-(4-propylpiperazin-1-yl)benzamide 142) N-((S)-1-((3aS,6S,6aR)-6-cyclopropyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-4-methyl-1-oxopentan-2-yl)-4-(4-methylpiperazin-1-yl)benzamide 143) N-((S)-1-((3aS,6S,6aR)-6-cyclopropyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-4-methyl-1-oxopentan-2-yl)-4-(4-ethylpiperazin-1-yl)benzamide 144) N-((S)-1-((3aS,6S,6aR)-6-cyclopropyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-4-methyl-1-oxopentan-2-yl)-4-(4-propylpiperazin-1-yl)benzamide 145) N-((S)-1-((3aS,6S,6aR)-6-(difluoromethyl)-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-4-methyl-1-oxopentan-2-yl)-4-(4-methylpiperazin-1-yl)benzamide 146) N-((S)-1-((3aS,6S,6aR)-6-(difluoromethyl)-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-4-methyl-1-oxopentan-2-yl)-4-(4-ethylpiperazin-1-yl)benzamide 147) N-((S)-1-((3aS,6S,6aR)-6-(difluoromethyl)-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-4-methyl-1-oxopentan-2-yl)-4-(4-propylpiperazin-1-yl)benzamide 148) N-((S)-4,4-dimethyl-1-((3aS,6S,6aR)-6-methyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-1-oxopentan-2-yl)-4-(4-methylpiperazin-1-yl)benzamide 149) N-((S)-4,4-dimethyl-1-((3aS,6S,6aR)-6-methyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-1-oxopentan-2-yl)-4-(4-ethylpiperazin-1-yl)benzamide 150) N-((S)-4,4-dimethyl-1-((3aS,6S,6aR)-6-methyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6 aH)-yl)-1-oxopentan-2-yl)-4-(4-propylpiperazin-1-yl)benzamide 151) N-((S)-1-((3aS,6S,6aR)-6-ethyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-4,4-dimethyl-1-oxopentan-2-yl)-4-(4-methylpiperazin-1-yl)benzamide 152) N-((S)-1-((3aS,6S,6aR)-6-ethyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-4,4-dimethyl-1-oxopentan-2-yl)-4-(4-ethylpiperazin-1-yl)benzamide 153) N-((S)-1-((3aS,6R,6aR)-6-ethyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-4,4-dimethyl-1-oxopentan-2-yl)-4-(4-propylpiperazin-1-yl)benzamide 154) N-((S)-4,4-dimethyl-1-oxo-1-((3aS,6S,6aR)-3-oxo-6-propyldihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)pentan-2-yl)-4-(4-methylpiperazin-1-yl)benzamide 155) N-((S)-4,4-dimethyl-1-oxo-1-((3aS,6S,6aR)-3-oxo-6-propyldihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)pentan-2-yl)-4-(4-ethylpiperazin-1-yl)benzamide 156) N-((S)-4,4-dimethyl-1-oxo-1-((3aS,6S,6aR)-3-oxo-6-propyldihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)pentan-2-yl)-4-(4-propylpiperazin-1-yl)benzamide 157) N-((S)-1-((3aS,6S,6aR)-6-isopropyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-4,4-dimethyl-1-oxopentan-2-yl)-4-(4-methylpiperazin-1-yl)benzamide 158) 4-(4-ethylpiperazin-1-yl)-N-((S)-1-((3aS,6S,6aR)-6-isopropyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6 aH)-yl)-4,4-dimethyl-1-oxopentan-2-yl)benzamide 159) N-((S)-1-((3aS,6S,6aR)-6-isopropyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-4,4-dimethyl-1-oxopentan-2-yl)-4-(4-propylpiperazin-1-yl)benzamide 160) N-((S)-1-((3aS,6S,6aR)-6-tert-butyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-4,4-dimethyl-1-oxopentan-2-yl)-4-(4-methylpiperazin-1-yl)benzamide 161) N-((S)-1-((3aS,6S,6aR)-6-tert-butyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-4,4-dimethyl-1-oxopentan-2-yl)-4-(4-ethylpiperazin-1-yl)benzamide 162) N-((S)-1-((3aS,6S,6aR)-6-tert-butyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-4,4-dimethyl-1-oxopentan-2-yl)-4-(4-propylpiperazin-1-yl)benzamide 163) N-((S)-1-((3aS,6S,6aR)-6-cyclopropyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-4,4-dimethyl-1-oxopentan-2-yl)-4-(4-methylpiperazin-1-yl)benzamide 164) N-((S)-1-((3aS,6S,6aR)-6-cyclopropyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-4,4-dimethyl-1-oxopentan-2-yl)-4-(4-ethylpiperazin-1-yl)benzamide 165) N-((S)-1-((3aS,6S,6aR)-6-cyclopropyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-4,4-dimethyl-1-oxopentan-2-yl)-4-(4-propylpiperazin-1-yl)benzamide 166) N-((S)-1-((3aS,6S,6aR)-6-(difluoromethyl)-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-4,4-dimethyl-1-oxopentan-2-yl)-4-(4-methylpiperazin-1-yl)benzamide 167) N-((S)-1-((3aS,6S,6aR)-6-(difluoromethyl)-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-4,4-dimethyl-1-oxopentan-2-yl)-4-(4-ethylpiperazin-1-yl)benzamide 168) N-((S)-1-((3aS,6S,6aR)-6-(difluoromethyl)-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-4,4-dimethyl-1-oxopentan-2-yl)-4-(4-propylpiperazin-1-yl)benzamide 169) N-((2S,3S)-3-methyl-1-((3aS,6S,6aR)-6-methyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-1-oxopentan-2-yl)-4-(4-methylpiperazin-1-yl)benzamide 170) 4-(4-ethylpiperazin-1-yl)-N-((2S,3S)-3-methyl-1-((3aS,6S,6aR)-6-methyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-1-oxopentan-2-yl)benzamide 171) N-((2S,3S)-3-methyl-1-((3aS,6S,6aR)-6-methyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-1-oxopentan-2-yl)-4-(4-propylpiperazin-1-yl)benzamide 172) N-((2S,3S)-1-((3aS,6S,6aR)-6-ethyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-3-methyl-1-oxopentan-2-yl)-4-(4-methylpiperazin-1-yl)benzamide 173) N-((2S,3S)-1-((3aS,6S,6aR)-6-ethyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-3-methyl-1-oxopentan-2-yl)-4-(4-ethylpiperazin-1-yl)benzamide 174) N-((2S,3S)-1-((3aS,6S,6aR)-6-ethyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-3-methyl-1-oxopentan-2-yl)-4-(4-propylpiperazin-1-yl)benzamide 175) N-((2S,3S)-3-methyl-1-oxo-1-((3aS,6S,6aR)-3-oxo-6-propyldihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)pentan-2-yl)-4-(4-methylpiperazin-1-yl)benzamide 176) 4-(4-ethylpiperazin-1-yl)-N-((2S,3S)-3-methyl-1-oxo-1-((3aS,6S,6aR)-3-oxo-6-propyldihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)pentan-2-yl)benzamide 177) N-((2S,3S)-3-methyl-1-oxo-1-((3aS,6S,6aR)-3-oxo-6-propyldihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)pentan-2-yl)-4-(4-propylpiperazin-1-yl)benzamide 178) N-((2S,3S)-1-((3aS,6S,6aR)-6-isopropyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-3-methyl-1-oxopentan-2-yl)-4-(4-methylpiperazin-1-yl)benzamide 179) 4-(4-ethylpiperazin-1-yl)-N-((2S,3S)-1-((3aS,6S,6aR)-6-isopropyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-3-methyl-1-oxopentan-2-yl)benzamide 180) N-((2S,3S)-1-((3aS,6S,6aR)-6-isopropyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-3-methyl-1-oxopentan-2-yl)-4-(4-propylpiperazin-1-yl)benzamide 181) N-((2S,3S)-1-((3aS,6S,6aR)-6-tert-butyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-3-methyl-1-oxopentan-2-yl)-4-(4-methylpiperazin-1-yl)benzamide 182) N-((2S,3S))-1-((3aS,6S,6aR)-6-tert-butyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-3-methyl-1-oxopentan-2-yl)-4-(4-ethylpiperazin-1-yl)benzamide 183) N-((2S,3S))-1-((3aS,6S,6aR)-6-tert-butyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-3-methyl-1-oxopentan-2-yl)-4-(4-propylpiperazin-1-yl)benzamide 184) N-((2S,3S)-1-((3aS,6S,6aR)-6-cyclopropyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-3-methyl-1-oxopentan-2-yl)-4-(4-methylpiperazin-1-yl)benzamide 185) N-((2S,3S)-1-((3aS,6S,6aR)-6-cyclopropyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-3-methyl-1-oxopentan-2-yl)-4-(4-ethylpiperazin-1-yl)benzamide 186) N-((2S,3S)-1-((3aS,6S,6aR)-6-cyclopropyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-3-methyl-1-oxopentan-2-yl)-4-(4-propylpiperazin-1-yl)benzamide 187) N-((2S,3S)-1-((3aS,6S,6aR)-6-(difluoromethyl)-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-3-methyl-1-oxopentan-2-yl)-4-(4-methylpiperazin-1-yl)benzamide 188) N-((2S,3S)-1-((3aS,6S,6aR)-6-(difluoromethyl)-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-3-methyl-1-oxopentan-2-yl)-4-(4-ethylpiperazin-1-yl)benzamide 189) N-((2S,3S)-1-((3aS,6S,6aR)-6-(difluoromethyl)-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-3-methyl-1-oxopentan-2-yl)-4-(4-propylpiperazin-1-yl)benzamide 190) N-((S)-3,3-dimethyl-1-((3aS,6S,6aR)-6-methyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-1-oxopentan-2-yl)-4-(4-methylpiperazin-1-yl)benzamide 191) N-((S)-3,3-dimethyl-1-((3aS,6S,6aR)-6-methyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-1-oxopentan-2-yl)-4-(4-ethylpiperazin-1-yl)benzamide 192) N-((S)-3,3-dimethyl-1-((3aS,6S,6aR)-6-methyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-1-oxopentan-2-yl)-4-(4-propylpiperazin-1-yl)benzamide 193) N-((S)-1-((3aS,6S,6aR)-6-ethyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-3,3-dimethyl-1-oxopentan-2-yl)-4-(4-methylpiperazin-1-yl)benzamide 194) N-((S)-1-((3aS,6S,6aR)-6-ethyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-3,3-dimethyl-1-oxopentan-2-yl)-4-(4-ethylpiperazin-1-yl)benzamide 195) N-((S)-1-((3aS,6S,6aR)-6-ethyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-3,3-dimethyl-1-oxopentan-2-yl)-4-(4-propylpiperazin-1-yl)benzamide 196) N-((S)-3,3-dimethyl-1-oxo-1-((3aS,6S,6aR)-3-oxo-6-propyldihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)pentan-2-yl)-4-(4-methylpiperazin-1-yl)benzamide 197) N-((S)-3,3-dimethyl-1-oxo-1-((3aS,6S,6aR)-3-oxo-6-propyldihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)pentan-2-yl)-4-(4-ethylpiperazin-1-yl)benzamide 198) N-((S)-3,3-dimethyl-1-oxo-1-((3aS,6S,6aR)-3-oxo-6-propyldihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)pentan-2-yl)-4-(4-propylpiperazin-1-yl)benzamide 199) N-((S)-1-((3aS,6S,6aR)-6-isopropyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-3,3-dimethyl-1-oxopentan-2-yl)-4-(4-methylpiperazin-1-yl)benzamide 200) 4-(4-ethylpiperazin-1-yl)-N-((S)-1-((3aS,6S,6aR)-6-isopropyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-3,3-dimethyl-1-oxopentan-2-yl)benzamide 201) N-((S)-1-((3aS,6S,6aR)-6-isopropyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-3,3-dimethyl-1-oxopentan-2-yl)-4-(4-propylpiperazin-1-yl)benzamide 202) N-((S)-1-((3aS,6S,6aR)-6-tert-butyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-3,3-dimethyl-1-oxopentan-2-yl)-4-(4-methylpiperazin-1-yl)benzamide 203) N-((S)-1-((3aS,6S,6aR)-6-tert-butyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-3,3-dimethyl-1-oxopentan-2-yl)-4-(4-ethylpiperazin-1-yl)benzamide 204) N-((S)-1-((3aS,6S,6aR)-6-tert-butyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-3,3-dimethyl-1-oxopentan-2-yl)-4-(4-propylpiperazin-1-yl)benzamide 205) N-((S)-1-((3aS,6S,6aR)-6-cyclopropyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-3,3-dimethyl-1-oxopentan-2-yl)-4-(4-methylpiperazin-1-yl)benzamide 206) N-((S)-1-((3aS,6S,6aR)-6-cyclopropyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-3,3-dimethyl-1-oxopentan-2-yl)-4-(4-ethylpiperazin-1-yl)benzamide 207) N-((S)-1-((3aS,6S,6aR)-6-cyclopropyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-3,3-dimethyl-1-oxopentan-2-yl)-4-(4-propylpiperazin-1-yl)benzamide 208) N-((S)-1-((3aS,6S,6aR)-6-(difluoromethyl)-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-3,3-dimethyl-1-oxopentan-2-yl)-4-(4-methylpiperazin-1-yl)benzamide 209) N-((S)-1-((3aS,6S,6aR)-6-(difluoromethyl)-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-3,3-dimethyl-1-oxopentan-2-yl)-4-(4-ethylpiperazin-1-yl)benzamide 210) N-((S)-1-((3aS,6S,6aR)-6-(difluoromethyl)-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-3,3-dimethyl-1-oxopentan-2-yl)-4-(4-propylpiperazin-1-yl)benzamide 211) N-((S)-1-cyclopentyl-2-((3aS,6S,6aR)-6-methyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-2-oxoethyl)-4-(4-methylpiperazin-1-yl)benzamide 212) N-((S)-1-cyclopentyl-2-((3aS,6S,6aR)-6-methyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-2-oxoethyl)-4-(4-ethylpiperazin-1-yl)benzamide 213) N-((S)-1-cyclopentyl-2-((3aS,6S,6aR)-6-methyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-2-oxoethyl)-4-(4-propylpiperazin-1-yl)benzamide 214) N-((S)-1-cyclopentyl-2-((3aS,6S,6aR)-6-ethyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-2-oxoethyl)-4-(4-methylpiperazin-1-yl)benzamide 215) N-((S)-1-cyclopentyl-2-((3aS,6S,6aR)-6-ethyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-2-oxoethyl)-4-(4-ethylpiperazin-1-yl)benzamide 216) N-((S)-1-cyclopentyl-2-((3aS,6S,6aR)-6-ethyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-2-oxoethyl)-4-(4-propylpiperazin-1-yl)benzamide 217) N-((S)-1-cyclopentyl-2-oxo-2-((3aS,6S,6aR)-3-oxo-6-propyldihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl) ethyl)-4-(4-methylpiperazin-1-yl)benzamide 218) N-((S)-1-cyclopentyl-2-oxo-2-((3aS,6S,6aR)-3-oxo-6-propyldihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl) ethyl)-4-(4-ethylpiperazin-1-yl)benzamide 219) N-((S)-1-cyclopentyl-2-oxo-2-((3aS,6S,6aR)-3-oxo-6-propyldihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl) ethyl)-4-(4-propylpiperazin-1-yl)benzamide 220) N-((S)-1-cyclopentyl-2-((3aS,6S,6aR)-6-isopropyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-2-oxoethyl)-4-(4-methylpiperazin-1-yl)benzamide 221) N-((S)-1-cyclopentyl-2-((3aS,6S,6aR)-6-isopropyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-2-oxoethyl)-4-(4-ethylpiperazin-1-yl)benzamide 222) N-((S)-1-cyclopentyl-2-((3aS,6S,6aR)-6-isopropyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-2-oxoethyl)-4-(4-propylpiperazin-1-yl)benzamide 223) N-((S)-2-((3aS,6S,6aR)-6-tert-butyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-1-cyclopentyl-2-oxoethyl)-4-(4-methylpiperazin-1-yl)benzamide 224) N-((S)-2-((3aS,6S,6aR)-6-tert-butyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-1-cyclopentyl-2-oxoethyl)-4-(4-ethylpiperazin-1-yl)benzamide 225) N-((S)-2-((3aS,6S,6aR)-6-tert-butyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-1-cyclopentyl-2-oxoethyl)-4-(4-propylpiperazin-1-yl)benzamide 226) N-((S)-1-cyclopentyl-2-((3aS,6S,6aR)-6-cyclopropyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-2-oxoethyl)-4-(4-methylpiperazin-1-yl)benzamide 227) N-((S)-1-cyclopentyl-2-((3aS,6S,6aR)-6-cyclopropyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-2-oxoethyl)-4-(4-ethylpiperazin-1-yl)benzamide 228) N-((S)-1-cyclopentyl-2-((3aS,6S,6aR)-6-cyclopropyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-2-oxoethyl)-4-(4-propylpiperazin-1-yl)benzamide 229) N-((S)-1-cyclopentyl-2-((3aS,6S,6aR)-6-(difluoromethyl)-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-2-oxoethyl)-4-(4-methylpiperazin-1-yl)benzamide 230) N-((S)-1-cyclopentyl-2-((3aS,6S,6aR)-6-(difluoromethyl)-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-2-oxoethyl)-4-(4-ethylpiperazin-1-yl)benzamide 231) N-((S)-1-cyclopentyl-2-((3aS,6S,6aR)-6-(difluoromethyl)-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-2-oxoethyl)-4-(4-propylpiperazin-1-yl)benzamide 232) N-((S)-1-cyclohexyl-2-((3aS,6S,6aR)-6-methyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-2-oxoethyl)-4-(4-methylpiperazin-1-yl)benzamide 233) N-((S)-1-cyclohexyl-2-((3aS,6S,6aR)-6-methyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-2-oxoethyl)-4-(4-ethylpiperazin-1-yl)benzamide 234) N-((S)-1-cyclohexyl-2-((3aS,6S,6aR)-6-methyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-2-oxoethyl)-4-(4-propylpiperazin-1-yl)benzamide 235) N-((S)-1-cyclopentyl-2-((3aS,6S,6aR)-6-ethyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-2-oxoethyl)-4-(4-methylpiperazin-1-yl)benzamide 236) N-((S)-1-cyclohexyl-2-((3aS,6S,6aR)-6-ethyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-2-oxoethyl)-4-(4-ethylpiperazin-1-yl)benzamide 237) N-((S)-1-cyclohexyl-2-((3aS,6S,6aR)-6-ethyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-2-oxoethyl)-4-(4-propylpiperazin-1-yl)benzamide 238) N-((S)-1-cyclohexyl-2-oxo-2-((3aS,6S,6aR)-3-oxo-6-propyldihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl) ethyl)-4-(4-methylpiperazin-1-yl)benzamide 239) N-((S)-1-cyclohexyl-2-oxo-2-((3aS,6S,6aR)-3-oxo-6-propyldihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl) ethyl)-4-(4-ethylpiperazin-1-yl)benzamide 240) N-((S)-1-cyclo hexyl-2-oxo-2-((3aS,6S,6aR)-3-oxo-6-propyldihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)ethyl)-4-(4-propylpiperazin-1-yl)benzamide 241) N-((S)-1-cyclo hexyl-2-((3aS,6S,6aR)-6-isopropyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-2-oxoethyl)-4-(4-methylpiperazin-1-yl)benzamide 242) N-((S)-1-cyclo hexyl-2-((3aS,6S,6aR)-6-isopropyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-2-oxoethyl)-4-(4-ethylpiperazin-1-yl)benzamide 243) N-((S)-1-cyclo hexyl-2-((3aS,6S,6aR)-6-isopropyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-2-oxoethyl)-4-(4-propylpiperazin-1-yl)benzamide 244) N-((S)-2-((3aS,6S,6aR)-6-tert-butyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-1-cyclo hexyl-2-oxoethyl)-4-(4-methylpiperazin-1-yl)benzamide 245) N-((S)-2-((3aS,6S,6aR)-6-tert-butyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-1-cyclo hexyl-2-oxoethyl)-4-(4-ethylpiperazin-1-yl)benzamide 246) N-((S)-2-((3aS,6S,6aR)-6-tert-butyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-1-cyclo hexyl-2-oxoethyl)-4-(4-propylpiperazin-1-yl)benzamide 247) N-((S)-1-cyclohexyl-2-((3aS,6S,6aR)-6-cyclopropyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-2-oxoethyl)-4-(4-methylpiperazin-1-yl)benzamide 248) N-((S)-1-cyclohexyl-2-((3aS,6S,6aR)-6-cyclopropyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-2-oxoethyl)-4-(4-ethylpiperazin-1-yl)benzamide 249) N-((S)-1-cyclohexyl-2-((3aS,6S,6aR)-6-cyclopropyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-2-oxoethyl)-4-(4-propylpiperazin-1-yl)benzamide 250) N-((S)-1-cyclohexyl-2-((3aS,6S,6aR)-6-(difluoromethyl)-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-2-oxoethyl)-4-(4-methylpiperazin-1-yl)benzamide 251) N-((S)-1-cyclohexyl-2-((3aS,6S,6aR)-6-(difluoromethyl)-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-2-oxoethyl)-4-(4-ethylpiperazin-1-yl)benzamide 252) N-((S)-1-cyclohexyl-2-((3aS,6S,6aR)-6-(difluoromethyl)-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-2-oxoethyl)-4-(4-propylpiperazin-1-yl)benzamide
26 . The method of claim 14 , wherein said compound is selected from the following:
a) N-((S)-4-methyl-1-((3aS,6R,6aR)-6-methyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-1-oxopentan-2-yl)-4-(4-methylpiperazin-1-yl)benzamide b) N-((2S,3S)-3-methyl-1-((3aS,6R,6aR)-6-methyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-1-oxopentan-2-yl)-4-(4-propylpiperazin-1-yl)benzamide c) N-((S)-3,3-dimethyl-1-((3aS,6R,6aR)-6-methyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-1-oxopentan-2-yl)-4-(4-methylpiperazin-1-yl)benzamide d) N-((S)-1-cyclopentyl-2-((3aS,6R,6aR)-6-methyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-2-oxoethyl)-4-(4-methylpiperazin-1-yl)benzamide e) N-((S)-4-methyl-1-((3aS,6S,6aR)-6-methyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-1-oxopentan-2-yl)-4-(4-methylpiperazin-1-yl)benzamide f) N-((S)-3,3-dimethyl-1-((3aS,6S,6aR)-6-methyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-1-oxopentan-2-yl)-4-(4-methylpiperazin-1-yl)benzamide g) N-((S)-1-cyclopentyl-2-((3aS,6S,6aR)-6-methyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-2-oxoethyl)-4-(4-methylpiperazin-1-yl)benzamide h) N-((S)-1-((3aS,6R,6aR)-6-(difluoromethyl)-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-4-methyl-1-oxopentan-2-yl)-4-(4-methylpiperazin-1-yl)benzamide i) N-((S)-1-((3aS,6R,6aR)-6-(difluoromethyl)-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-3,3-dimethyl-1-oxopentan-2-yl)-4-(4-methylpiperazin-1-yl)benzamide j) N-((2S,3S)-1-((3aS,6R,6aR)-6-(difluoromethyl)-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-3-methyl-1-oxopentan-2-yl)-4-(4-methylpiperazin-1-yl)benzamide k) N-((S)-1-cyclopentyl-2-((3aS,6R,6aR)-6-(difluoromethyl)-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-2-oxoethyl)-4-(4-methylpiperazin-1-yl)benzamide l) N-((S)-1-((3aS,6S,6aR)-6-(difluoromethyl)-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-4-methyl-1-oxopentan-2-yl)-4-(4-methylpiperazin-1-yl)benzamide m) N-((S)-1-((3aS,6S,6aR)-6-(difluoromethyl)-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-3,3-dimethyl-1-oxopentan-2-yl)-4-(4-methylpiperazin-1-yl)benzamide n) N-((2S,3S)-1-((3aS,6S,6aR)-6-(difluoromethyl)-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-3-methyl-1-oxopentan-2-yl)-4-(4-methylpiperazin-1-yl)benzamide o) N-((S)-1-cyclopentyl-2-((3aS,6S,6aR)-6-(difluoromethyl)-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-2-oxoethyl)-4-(4-methylpiperazin-1-yl)benzamide p) N-((S)-1-((3aS,6R,6aR)-6-ethyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-3,3-dimethyl-1-oxobutan-2-yl)-4-(4-methylpiperazin-1-yl)benzamide q) N-((S)-1-((3aS,6R,6aR)-6-isopropyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-3,3-dimethyl-1-oxobutan-2-yl)-4-(4-methylpiperazin-1-yl)benzamide r) N-((S)-1-((3aS,6S,6aR)-6-ethyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-3,3-dimethyl-1-oxobutan-2-yl)-4-(4-methylpiperazin-1-yl)benzamide s) N-((S)-1-((3aS,6S,6aR)-6-isopropyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-3,3-dimethyl-1-oxobutan-2-yl)-4-(4-methylpiperazin-1-yl)benzamide t) N-((S)-1-cyclopentyl-2-((3aS,6R,6aR)-6-ethyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-2-oxoethyl)-4-(4-methylpiperazin-1-yl)benzamide u) N-((S)-1-cyclopentyl-2-((3aS,6R,6aR)-6-isopropyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-2-oxoethyl)-4-(4-methylpiperazin-1-yl)benzamide v) N-((S)-1-cyclopentyl-2-((3aS,6S,6aR)-6-ethyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-2-oxoethyl)-4-(4-methylpiperazin-1-yl)benzamide w) N-((S)-1-cyclopentyl-2-((3aS,6S,6aR)-6-isopropyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-2-oxoethyl)-4-(4-methylpiperazin-1-yl)benzamide x) N-((S)-1-cyclopentyl-2-oxo-2-((3aS,6S,6aR)-3-oxo-6-propyldihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)ethyl)-4-(4-methylpiperazin-1-yl)benzamide y) N-((S)-1-cyclopentyl-2-((3aS,6S,6aR)-6-cyclopropyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-2-oxoethyl)-4-(4-methylpiperazin-1-yl)benzamide z) N-((S)-2-((3aS,6S,6aR)-6-benzyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-1-cyclopentyl-2-oxoethyl)-4-(4-methylpiperazin-1-yl)benzamide aa) N-((S)-2-((3aS,6S,6aR)-6-methyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-1-(1-methylcyclopentyl)-2-oxoethyl)-4-(4-methylpiperazin-1-yl)benzamide and bb) N-((S)-2-((3aS,6R,6aR)-6-methyl-3-oxodihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-1-(1-methylcyclopentyl)-2-oxoethyl)-4-(4-methylpiperazin-1-yl)benzamide.Join the waitlist — get patent alerts
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