Interactive and analytical system that provides a dynamic tool for therapies to prevent and cure dementia-related diseases

Abstract

A computer-implemented method, system, and apparatus for providing interactive and analytical components that provide a comprehensive and dynamic tool for therapies to prevent and cure dementia-related diseases. The invention includes one or more computers that receive and store personal information for people, including personal background information, pre-existing conditions, current medications, genomic data and diagnostic information. The computers also generate synergic data containing compounded probability data specifying an expected adjustment of individual biological mechanisms from particular combinations of therapies. For each person, the computers process personal information and identify a subset of biological mechanisms that are principally affected by dementia-related diseases or the substantial risk of dementia-related diseases. The computers also apply the personal information including the principally-affected biological mechanisms to the therapy data and generate for each person one or more messages communicating a therapy plan containing a combination of therapies and determines how to apply the therapies.

What is claimed is: 
     
         1 . A computer system having interactive and analytical components that provides a comprehensive and dynamic tool for therapies to prevent, slow the progression of, or cure dementia-related diseases, comprising:
 one or more computers, associated and connected non-transient electronic storage containing data and computer-executable instructions, and network communications connections with remote computers over networks, wherein the computers, electronic storage, and network communications connections together configure the computer system to:
 receive and store personal information for people including personal and family background information, pre-existing conditions, current medications, genomic data, and diagnostic information containing data values for a diverse significantly-sized group of biological mechanisms that define dementia-related diseases as a medical condition or define a substantial risk of dementia-related diseases; 
 receive and store therapy data that identifies individual therapies and specifies corresponding individual ones of the biological mechanisms that the therapy targets to adjust a physiological state of corresponding biological mechanisms into recommended target states for each biological mechanism, wherein the therapy data contains variations found in the individual therapy's effect on corresponding target biological mechanisms as a function of personal background data and also contains data quantifying a probability of success of the therapy; 
 generate synergic data containing compounded probability data specifying an expected adjustment of individual biological mechanisms resulting from particular combinations of therapies and a probability reflecting the likelihood of reaching those therapy results; 
 for each person, processing personal information and as a result, identify a subset of the biological mechanisms that are principally affected by dementia-related diseases or a substantial risk of dementia-related diseases based on the biological mechanisms associated data value for that person; 
 apply personal information, including the principally-affected biological mechanisms, data quantifying pre-existing conditions, and data specifying current medications, to the therapy data and generate, for each person, one or more messages communicating a therapy plan containing a combination of therapies and determines whether to apply the therapies in the therapy plan simultaneously, sequentially, or combinations thereof and the prescribed period for each therapy, wherein the therapy plan is selected from generating combinations of therapies that together have data characteristics that target the biological mechanisms that are principally affected for that person, and the system generates the therapy plan by comparing probabilities of success of combinations of therapies and conflicts in components of therapies in therapy combinations and differentiating combinations using the probabilities and conflicts; 
 receive streams of diagnostic and testing data from diverse remote systems that generate current values associated with the biological mechanisms in people and applying the streams to monitor the status of the biological mechanisms in people during the therapy plan over time spans that are distanced shortly apart; 
 dynamically refining individual therapy plans when the monitoring determines at least one targeted biological mechanism, which was targeted for that person, is found to have been adjusted to be within a recommended range for the disease, wherein modifying is performed by reapplying updated personal information and therapy information and generating a modified therapy plan; and 
 dynamically modifying therapy data utilizing data from the data store to incorporate data from monitoring people and updating the probabilities and associated targeted biological mechanisms for individual therapies and combinations of therapies. 
   
     
     
         2 . The computer system of  claim 1  is further configured to include a therapy optimization module that receives personal monitoring data and personal background information and modifies the therapy plan, wherein the modification optimizes a dosage in one of the therapies in the therapy plan. 
     
     
         3 . The computer system of  claim 2  is further configured to include a maintenance module that operates when the computer systems determines that a targeted biological mechanism for a person has been adjusted to be within the recommended target range for the disease and issues messages that contain a maintenance plan as part of the therapy plan that is determined to be issued and contains data that maintains the adjusted biological mechanism within the recommended range. 
     
     
         4 . The computer system of  claim 3  wherein the computer system is configured to accept as input additional relevant information about the individual, including the results of additional diagnostic testing before providing additional therapy. 
     
     
         5 . The computer system of  claim 1  wherein the computer system is configured to provide an interactive interface with which doctors, caregivers, patients, and other people interested in cognitive health interacts to view therapy plans, diagnostic information, or therapy progress. 
     
     
         6 . The computer system of  claim 1  wherein the computer system is configured to include network connections to the Internet for interacting with doctors, caregivers, patients, and other people interested in cognitive health and configured to include secured data storage that limits access to therapy and personal data based on credentials of requestor. 
     
     
         7 . The computer system of  claim 1  wherein the list of actions includes questions that provide additional information that the system has identified to be most likely to lead to raising the likelihood of success with a current therapy or combination of therapies. 
     
     
         8 . The computer system of  claim 1  wherein the therapy plan additionally generates recommendations or a list of actions in a priority order. 
     
     
         9 . The computer system of  claim 1  wherein data is stored from a data store that includes a pool of data collected from people from various sources that document diagnostic and physical experiences of people having no symptoms, or symptoms or therapy related to dementia-related diseases. 
     
     
         10 . The computer system of  claim 1  further configured to configure a new therapy insertion module that receives new therapies and associated therapy data into the system and in response, the system automatically incorporates the new therapies in identifying therapy plans for people. 
     
     
         11 . A computer system that treats dementia-related diseases, comprising:
 one or more computers, associated and connected non-transient electronic storage containing data and computer-executable instructions, and network communications connections with remote computers over networks, wherein the computers, electronic storage, and network communications connections together configure the computer system to:   receive and store a stream of user information containing user background information, pre-existing conditions, current medications and diagnostic information containing data values for a diverse significantly-sized group of physiological mechanisms that define dementia-related diseases as a medical condition or define a substantial risk of dementia-related diseases as a medical condition;   receive and store a stream of therapy information containing individual therapies for the mechanisms and associated probabilities of success of the therapy in treating a corresponding biological mechanism based on base values of different user background information;   process the user information and therapy information, and based on the processing identify specific combinations of therapies as individual therapy plans, wherein the specific combinations of therapies are individual good matches for a corresponding set of principally affected biological mechanisms for people having certain corresponding sets of base values of background information, wherein the therapy plan additionally includes recommendations or a list of actions in a priority order;   store data from a data store that includes a pool of data collected from people from various sources that document diagnostic and physical experiences of people having no symptoms, or symptoms or therapy related to dementia-related diseases;   receive and process monitoring and tracking information containing values identifying current physiological states of the biological mechanisms for people and storing the values in association with the person and corresponding therapy and therapy plan;   determine from the stream of monitoring and tracking information whether one of a plurality of measurements associated with biological mechanisms for a person has been sufficiently adjusted and in response, modifying that user therapy plan to target another biological mechanism and maintain operation of the adjusted mechanism;   dynamically identify from the tracking and monitoring information including the measured physiological state of biological mechanisms in the information a new therapy, as a result of the system processing the stream of tracking and monitoring information from existing therapy plans, wherein the new therapy is defined by a new combination of therapies that will have combinational success based on processing the tracking and monitoring information;   dynamically modifying or eliminating existing therapy plans when the stream of tracking and monitoring information from existing therapy plans shows that the actual performance is not converging in the desired direction; and   issue messages that communicate the new therapy or modified therapies to a doctor, health care provider, caregiver, or a person's computer devices.