5-aminolevulinic acid derivatives, methods for their preparation and uses thereof

Abstract

There are provided conjugates comprising 5-aminolevulinic acid (5-ALA), an aldehyde and a carboxylic acid (e.g., a histone deacetylase inhibitor), compositions comprising same, methods for their preparation and uses thereof for treatment of cancer and anemia, and for inducing erythropoiesis.

What is claimed is: 
     
         1 . A method for the treatment or prevention of anemia, or for the induction of erythropoiesis comprising the step of administering to a subject in need thereof a composition comprising Histone deacetylase (HDAC)-inhibitor and 5-aminolevulinic acid (5-ALA) or an ester thereof. 
     
     
         2 . The method of  claim 1 , wherein the ester is a methyl or a hexyl ester. 
     
     
         3 . The method of  claim 1 , wherein the HDAC inhibitor is a carboxylic acid. 
     
     
         4 . The method of  claim 3 , wherein the carboxylic acid is selected from the group consisting of pivalic, butyric, valeric, hexanoic, heptanoic, octanoic, decanoic, 4-phenylbutyric, 4-phenylacetic and retinoic acid. 
     
     
         5 . The method of  claim 3 , wherein the carboxylic acid is butyric, octanoic, decanoic or valeric acid. 
     
     
         6 . The method of  claim 3 , wherein the carboxylic acid is butyric acid or octanoic acid. 
     
     
         7 . The method of  claim 1 , wherein the composition is in a form suitable for oral administration, parenteral administration, topical administration, dermatological administration, administration by inhalation, or administration via a suppository. 
     
     
         8 . The method of  claim 1 , wherein the composition is in a form suitable for oral administration, intravenous administration by injection, or administration by inhalation. 
     
     
         9 . The method of  claim 1 , wherein the HDAC inhibitor is an inhibitor of a Class I HDAC and/or a Class II HDAC. 
     
     
         10 . The method of  claim 1 , wherein the HDAC inhibitor is a lysine deacetylase inhibitor.