Anti-Scalping Transdermal Patch Packaging Film

Abstract

A flexible, multilayer packaging film suitable for packaging an article for collecting or administering a physiologically active substance such as transdermal drug delivery patches, oral dissolvable thin strips, and disposable, microfluidic test cassettes having: (a) an article contact layer having at least 90 wt. % of a norbornene ethylene copolymer or derivative thereof and a glass transition temperature of from 65 to 110° C.; (b) a polyolefin bulk layer; (c) a first intermediate adhesive layer; (d) an oxygen barrier layer having an oxygen transmission rate of less than less than 0.01 cm 3 /100 inches 2 /24 hours at 1 atmosphere and 23° C.; (e) a second intermediate adhesive layer; and (f) an exterior protective layer comprising a polymer selected from the group consisting of amorphous polyester, polyamide, polyolefin, nylon, polypropylene, or copolymers, blends or derivatives thereof; wherein said multilayer film has the following properties: a WVTR of less than 0.01 g/100 inches 2 per 24 hours at Room Temperature (RT) (23° C.) and 1 atmosphere; and a thickness of 10 mil or less.

What is claimed is: 
     
         1 . A drug scalping resistant, flexible, multilayer packaging film comprising:
 (a) a drug contact layer having at least 90 wt. % of an ethylene norbornene copolymer or derivative thereof having a glass transition temperature of from 65 to 110° C.;   (b) a polyolefin bulk layer;   (c) a first intermediate adhesive layer;   (d) an oxygen barrier layer having an oxygen transmission rate of less than less than 0.01 cm 3 /100 inches 2 /24 hours at 1 atmosphere and 23° C.;   (e) a second intermediate adhesive layer; and   (f) an exterior protective layer comprising a polymer selected from the group consisting of paper, oriented polyester, amorphous polyester, polyamide, polyolefin, nylon, polypropylene, or copolymers, blends or derivatives thereof;   wherein said multilayer film has the following properties:   a WVTR of less than 0.01 g/100 inches 2  per 24 hours at Room Temperature (RT) (23° C.) and 1 atmosphere.   
     
     
         2 . A multilayer film as defined in  claim 1 , wherein: said contact layer comprises at least 95 wt. % ethylene norbornene copolymer or derivative thereof. 
     
     
         3 . A multilayer film as defined in  claim 1 , wherein: said contact layer consists essentially of ethylene norbornene copolymer or derivative thereof. 
     
     
         4 . A multilayer film as defined in  claim 1 , wherein said film is formed into a flexible container and further comprises a transdermal patch sealed therein. 
     
     
         5 . A multilayer film as defined in  claim 4 , wherein said patch is a nicotine or fentanyl drug delivery patch.