Method of Maintaining Oral Health in Animals

Abstract

Use of a compound having the formula (I) in the manufacture of a medicament for the prevention or treatment of a diseased caused by oral bacterial in an animal Formula (I); wherein R 1 is a straight or branched alkyl group containing 8 to 16 carbon atoms at the 2- or 3-position of the morpholino ring, and R 2 is a straight or branched alkyl group containing 2 to 10 carbon atoms, substituted with a hydroxyl group except in the alpha-position, or a pharmaceutically acceptable salt thereof.

We claim: 
     
         1 . A method for preventing or treating a disease caused by oral bacteria in a non-human animal, wherein said method comprises administering to the animal a compound of formula (I): 
       
         
           
           
               
               
           
         
         wherein R 1  is a straight or branched alkyl group containing 8 to 16 carbon atoms at the 2- or 3-position of the morpholino ring, and R 2  is a straight or branched alkyl group containing 2 to 10 carbon atoms, substituted with a hydroxy group except in the alpha-position, or a pharmaceutically acceptable salt thereof. 
       
     
     
         2 . A cosmetic method of preventing or decreasing oral staining in an animal, comprising the step of exposing the oral cavity to a morpholino compound of general formula (I): 
       
         
           
           
               
               
           
         
         wherein R 1  is a straight or branched alkyl group containing 8 to 16 carbon atoms at the 2- or 3-position of the morpholino ring, and R 2  is a straight or branched alkyl group containing 2 to 10 carbon atoms, substituted with a hydroxy group except in the alpha-position, or a pharmaceutically acceptable salt thereof. 
       
     
     
         3 . An animal chew or foodstuff comprising a compound of formula (I): 
       
         
           
           
               
               
           
         
         wherein R 1  is a straight or branched alkyl group containing 8 to 16 carbon atoms at the 2- or 3-position of the morpholino ring, and R 2  is a straight or branched alkyl group containing 2 to 10 carbon atoms, substituted with a hydroxy group except in the alpha-position, or a pharmaceutically acceptable salt thereof.