US2015250695A1PendingUtilityA1
Stabilization of cosmetic compositions
Est. expiryAug 30, 2027(~1.1 yrs left)· nominal 20-yr term from priority
A61K 8/4973A61K 2800/592A61Q 19/00A61K 8/375A61Q 17/04A61K 8/37A61K 8/35A61K 8/368A61K 8/4966A61K 8/40A61K 8/494A61K 8/49
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Claims
Abstract
Disclosed is the use of UV absorbers selected from (a 1 ) diphenylacrylates; (a 2 ) hydroxyphenyl triazines of formula (1), in which R 1 , R 2 and R 3 independently of one another, are C 1 -C 18 alkyl; (a 3 ) benzotriazole derivatives of formula (2), wherein R 4 is a random statistical mixture of at least three isomeric branched secondary alkyl groups each having 8 to 30 carbon atoms and having the formula (2a); E 1 is a straight-chain C 1 -C 14 alkyl; E 2 is a straight-chain C 4 -C 15 alkyl; wherein the total number of carbon atoms in E 1 plus E 2 is from 7 to 29; and R 5 is C 1 -C 5 alkyl; and (a 4 ) dialkyl naphthalate; for stabilizing cosmetic compositions comprising (b) symmetrical triazine derivatives of formula (3), wherein A is a radical of formula (3a); or (3b) R 6 and R 10 independently from each other are hydrogen; C 1 -C 18 alkyl; or C 6 -C 12 aryl; R 7 , R 8 and R 9 independently from each other are hydrogen; or a radical of formula (3c), wherein, in formula (3a), at least one of the radicals R 7 , R 8 and R 9 are a radical of formula (3c); R 11 , R 12 , R 13 and R 14 independently from each other are hydrogen; hydroxy; halogen; C 1 -C 18 alkyl; C 1 -C 18 alkoxy; C 6 -C 12 aryl; biphenylyl; C 6 -C 12 aryloxy; C 1 -C 18 alkylthio; carboxy; —COOM; C 1 -C 18 -alkylcarboxyl; aminocarbonyl; mono- or di-C 1 -C 18 alkylamino; C 1 -C 10 acylamino; or —COOH; M is an alkali metal ion; x is 1 or 2; and y is a number from 2 to 10; and a UV-absorber selected from (c 1 ) cinnamic acid derivatives; and (C 2 ) dibenzoylmethane derivatives.
Claims
exact text as granted — not AI-modified1 .- 19 . (canceled)
20 . A method of treating the combination of components b and c 1 in a cosmetic formulation in need of stabilization comprising:
adding UV absorbers, wherein the UV absorbers are (a 1 ) diphenylacrylates; and (a 2 ) hydroxyphenyl triazines of formula (1) shown below:
in which
R 1 , R 2 and R 3 independently of one another, are C 1 -C 18 alkyl;
to a cosmetic composition comprising:
(b) symmetrical triazine derivatives of formula
wherein
A is a radical of formula
R 6 and R 10 independently from each other are hydrogen; C 1 -C 18 alkyl; or C 6 -C 12 aryl;
R 7 , R 8 and R 9 independently from each other are hydrogen; or a radical of formula
wherein, in formula (3a), at least one of the radicals R 7 , R 8 and R 9 are a radical of formula (3c);
R 11 , R 12 , R 13 and R 14 independently from each other are hydrogen; hydroxy; halogen; C 1 -C 18 alkyl; C 1 -C 18 alkoxy; C 6 -C 12 aryl; biphenylyl; C 6 -C 12 aryloxy; C 1 -C 18 alkylthio; carboxy; —COOM; C 1 -C 18 -alkylcarboxyl; aminocarbonyl; or mono- or di-C 1 -C 18 alkylamino; C 1 -C 10 acylamino; or —COOH;
M is an alkali metal ion;
x is 1 or 2; and
y is a number from 2 to 10; and
(c 1 ) cinnamic acid derivatives.
21 . The method of claim 20 , wherein the (a 1 ) diphenylacrylates are 2-ethylhexyl 2-cyano-3,3-diphenylacrylate or 3-(benzofuranyl) 2-cyanoacrylate.
22 . The method of claim 20 , wherein the (c 1 ) cinnamic acid derivatives correspond to formula (14) shown below:
wherein
R 16 and R 17 independently from each other are hydrogen, hydroxy, C 1 -C 5 alkyl, or C 1 -C 5 alkoxy; and
R 18 is C 1 -C 5 alkyl.
23 . The method of claim 20 , wherein the (c 1 ) cinnamic acid derivative is 2-ethylhexyl 4-methoxycinnamate.
24 . A method of treating the combination of components b and c 1 in a cosmetic formulation in need of stabilization comprising:
adding UV absorbers, wherein the UV absorbers are (a 1 ) diphenylacrylates; and (a 3 ) benzotriazole derivatives of formula (2) shown below:
wherein
R 4 is a random statistical mixture of at least three isomeric branched secondary alkyl groups each having 8 to 30 carbon atoms and having the formula
E 1 is a straight-chain C 1 -C 14 alkyl;
E 2 is a straight-chain C 4 -C 15 alkyl; wherein the total number of carbon atoms in E 1 plus E 2 is from 7 to 29; and
R 5 is C 1 -C 5 alkyl; and
to a cosmetic composition comprising:
(b) symmetrical triazine derivatives of formula
wherein
A is a radical of formula
R 6 and R 10 independently from each other are hydrogen; C 1 -C 18 alkyl; or C 6 -C 12 aryl;
R 7 , R 8 and R 9 independently from each other are hydrogen; or a radical of formula
wherein, in formula (3a), at least one of the radicals R 7 , R 8 and R 9 are a radical of formula (3c);
R 11 , R 12 , R 13 and R 14 independently from each other are hydrogen; hydroxy; halogen; C 1 -C 18 alkyl; C 1 -C 18 alkoxy; C 6 -C 12 aryl; biphenylyl; C 6 -C 12 aryloxy; C 1 -C 18 alkylthio; carboxy; —COOM; C 1 -C 18 -alkylcarboxyl; aminocarbonyl; or mono- or di-C 1 -C 18 alkylamino; C 1 -C 10 acylamino; or —COOH;
M is an alkali metal ion;
x is 1 or 2; and
y is a number from 2 to 10; and
(c 1 ) cinnamic acid derivatives.
25 . The method of claim 24 , wherein the (a 1 ) diphenylacrylates are 2-ethylhexyl 2-cyano-3,3-diphenylacrylate or 3-(benzofuranyl) 2-cyanoacrylate.
26 . The method of claim 24 , wherein the (c 1 ) cinnamic acid derivatives correspond to formula (14) shown below:
wherein
R 16 and R 17 independently from each other are hydrogen, hydroxy, C 1 -C 5 alkyl, or C 1 -C 5 alkoxy; and
R 18 is C 1 -C 5 alkyl.
27 . The method of claim 24 , wherein the (c 1 ) cinnamic acid derivative is 2-ethylhexyl 4-methoxycinnamate.
28 . A method of treating the combination of components b and c 1 in a cosmetic formulation in need of stabilization comprising:
adding UV absorbers, wherein the UV absorbers are (a 1 ) diphenylacrylates; and (a 4 ) dialkyl naphthalate; to a cosmetic composition comprising: (b) symmetrical triazine derivatives of formula
wherein
A is a radical of formula
R 6 and R 10 independently from each other are hydrogen; C 1 -C 18 alkyl; or C 6 -C 12 aryl;
R 7 , R 8 and R 9 independently from each other are hydrogen; or a radical of formula
wherein, in formula (3a), at least one of the radicals R 7 , R 8 and R 9 are a radical of formula (3c);
R 11 , R 12 , R 13 and R 14 independently from each other are hydrogen; hydroxy; halogen; C 1 -C 18 alkyl; C 1 -C 18 alkoxy; C 6 -C 12 aryl; biphenylyl; C 6 -C 12 aryloxy; C 1 -C 18 alkylthio; carboxy; —COOM; C 1 -C 18 -alkylcarboxyl; aminocarbonyl; or mono- or di-C 1 -C 18 alkylamino; C 1 -C 10 acylamino; or —COOH;
M is an alkali metal ion;
x is 1 or 2; and
y is a number from 2 to 10; and
(c 1 ) cinnamic acid derivatives.
29 . The method of claim 28 , wherein the (a 1 ) diphenylacrylates are 2-ethylhexyl 2-cyano-3,3-diphenylacrylate or 3-(benzofuranyl) 2-cyanoacrylate.
30 . The method of claim 28 , wherein the (c 1 ) cinnamic acid derivatives correspond to formula (14) shown below:
wherein
R 16 and R 17 independently from each other are hydrogen, hydroxy, C 1 -C 5 alkyl, or C 1 -C 5 alkoxy; and
R 18 is C 1 -C 5 alkyl.
31 . The method of claim 28 , wherein the (c 1 ) cinnamic acid derivative is 2-ethylhexyl 4-methoxycinnamate.
32 . A cosmetic composition comprising:
(a 1 ) diphenylacrylates; (b) symmetrical triazine derivatives of formula
wherein
A is a radical of formula
R 6 and R 10 independently from each other are hydrogen; C 1 -C 18 alkyl; or C 6 -C 12 aryl;
R 7 , R 8 and R 9 independently from each other are hydrogen; or a radical of formula
wherein, in formula (3a), at least one of the radicals R 7 , R 8 and R 9 are a radical of formula (3c);
R 11 , R 12 , R 13 and R 14 independently from each other are hydrogen; hydroxy; halogen; C 1 -C 18 alkyl; C 1 -C 18 alkoxy; C 6 -C 12 aryl; biphenylyl; C 6 -C 12 aryloxy; C 1 -C 18 alkylthio; carboxy; —COOM; C 1 -C 18 -alkylcarboxyl; aminocarbonyl; or mono- or di-C 1 -C 18 alkylamino; C 1 -C 10 acylamino; or —COOH;
M is an alkali metal ion;
x is 1 or 2; and
y is a number from 2 to 10; and
(c 1 ) cinnamic acid derivatives,
wherein the composition is stable.
33 . The cosmetic composition of claim 32 comprising:
0.1 to 10% b.w. of the diphenylacrylates (a 1 );
0.1 to 10. % b.w. of the symmetrical triazine (b); and
0.1 to 10% b.w. of the cinnamic acid derivative (c 1 ).
34 . The cosmetic composition of claim 32 , wherein the (a 1 ) diphenylacrylates are 2-ethylhexyl 2-cyano-3,3-diphenylacrylate or 3-(benzofuranyl) 2-cyanoacrylate.
35 . The cosmetic composition of claim 32 , wherein the (c 1 ) cinnamic acid derivatives correspond to formula (14) shown below:
wherein
R 16 and R 17 independently from each other are hydrogen, hydroxy, C 1 -C 5 alkyl, or C 1 -C 5 alkoxy; and
R 18 is C 1 -C 5 alkyl.
36 . The cosmetic composition of claim 32 , wherein the (c 1 ) cinnamic acid derivative is 2-ethylhexyl 4-methoxycinnamate.
37 . The cosmetic composition of claim 32 , further comprises one of (a 2 ), (a 3 ), or (a 4 ),
wherein (a 2 ), (a 3 ), or (a 4 ) are defined hereinbelow: (a 2 ) hydroxyphenyl triazines of formula (1) shown below:
in which
R 1 , R 2 and R 3 independently of one another, are C 1 -C 18 alkyl;
(a 3 ) benzotriazole derivatives of formula (2) shown below:
wherein
R 4 is a random statistical mixture of at least three isomeric branched secondary alkyl groups each having 8 to 30 carbon atoms and having the formula
E 1 is a straight-chain C 1 -C 14 alkyl;
E 2 is a straight-chain C 4 -C 15 alkyl; wherein the total number of carbon atoms in E 1 plus E 2 is from 7 to 29; and
R 5 is C 1 -C 5 alkyl; or
(a 4 ) dialkyl naphthalate.
38 . A method of using the cosmetic composition of claim 37 comprising enhancing the stability of the cosmetic composition by combining the (a 1 ), the (b), and the (c 1 ) with one of the (a 2 ), the (a 3 ), or the (a 4 ).Cited by (0)
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