US2015250921A1PendingUtilityA1

Method of preparing porous carbonate apatite from natural bone

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Assignee: COLLAGEN MATRIX INCPriority: Sep 29, 2011Filed: Mar 13, 2015Published: Sep 10, 2015
Est. expirySep 29, 2031(~5.2 yrs left)· nominal 20-yr term from priority
Inventors:Shu-Tung LiHui-Chen ChenDebbie Yuen
C01P 2006/90C01B 25/16A61L 27/56C01P 2002/82A61L 27/12C01P 2002/90C01B 25/32A61L 27/58C01P 2006/80A61L 2430/02C01P 2006/12C01P 2002/72
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Claims

Abstract

A carbonate apatite prepared from natural bone. The carbonate apatite has a protein content of 2000-8000 parts per million and a surface area of 15 to 70 m 2 /g. Also provided is a method for preparing the carbonate apatite from cancellous bone particles.

Claims

exact text as granted — not AI-modified
1 . A carbonate apatite prepared from natural bone, the carbonate apatite having a surface area of 15 to 70 m 2 /g and a protein content of 2000-8000 parts per million. 
     
     
         2 . The carbonate apatite of  claim 1 , wherein the carbonate apatite has a carbonate content of 1 to 7%. 
     
     
         3 . The carbonate apatite of  claim 2 , wherein the carbonate apatite has a degree of crystallinity of 45 to 65%. 
     
     
         4 . The carbonate apatite of  claim 1 , wherein the carbonate apatite has a degree of crystallinity of 45 to 65%. 
     
     
         5 . A carbonate apatite prepared from natural bone by the steps consisting of:
 providing cancellous bone particles;   treating the bone particles with hot water and an organic solvent;   repeating the treating step at least once;   drying the treated bone particles; and   heating the treated dried bone particles at 500° C. to 620° C. for 10 to 50 hours,   
       wherein the carbonate apatite has a protein content of 2000-8000 parts per million. 
     
     
         6 . The carbonate apatite of  claim 5 , wherein the carbonate apatite has a surface area of 15 to 70 m 2 /g. 
     
     
         7 . The carbonate apatite of  claim 6 , wherein the carbonate apatite has a carbonate content of 1 to 7%. 
     
     
         8 . The carbonate apatite of  claim 7 , wherein the carbonate apatite has a degree of crystallinity of 45 to 65%. 
     
     
         9 . The carbonate apatite of  claim 5 , wherein the carbonate apatite has a carbonate content of 1 to 7%. 
     
     
         10 . The carbonate apatite of  claim 9 , wherein the carbonate apatite has a degree of crystallinity of 45 to 65%. 
     
     
         11 . The carbonate apatite of  claim 5 , wherein the carbonate apatite has a degree of crystallinity of 45 to 65%. 
     
     
         12 . The carbonate apatite of  claim 11 , wherein the carbonate apatite has a surface area of 15 to 70 m 2 /g. 
     
     
         13 . The method of  claim 5 , wherein the organic solvent is isopropanol. 
     
     
         14 . The method of  claim 6 , wherein the organic solvent is isopropanol. 
     
     
         15 . The method of  claim 5 , wherein the temperature of the hot water is 80° C. to 100° C. 
     
     
         16 . The method of  claim 6 , wherein the temperature of the hot water is 80° C. to 100° C. 
     
     
         17 . The method of  claim 7 , wherein the organic solvent is isopropanol. 
     
     
         18 . The method of  claim 8 , wherein the organic solvent is isopropanol. 
     
     
         19 . The method of  claim 7 , wherein the temperature of the hot water is 80° C. to 100° C. 
     
     
         20 . The method of  claim 8 , wherein the temperature of the hot water is 80° C. to 100° C.

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