AMPK Modulators

Abstract

The present invention relates to compounds and pharmaceutically acceptable salts, esters and prodrugs of Formula (I) or (II): which are useful as AMPK modulators effective in treating diabetes, obesity and cancer in a subject.

1 . A compound represented by formula I or II: 
       
         
           
           
               
               
           
         
       
       and salts thereof, wherein:
 X 1 -X 4  are independently selected from the group consisting of C, CR 1 , O, S, or N, where R 1  is hydrogen or an electron releasing group; 
 Y 1  is O, S, N or NH; 
 Y 2 -Y 3  are independently selected from the group consisting of C, CR 1 , O, S, N or NH; 
 
       
         
           
           
               
               
           
         
       
       is independently selected from the group consisting of heteroaryl, substituted heteroaryl, heterocyclic, substituted heterocyclic; where Z is O, N or NH; and 
       
         
           
           
               
               
           
         
       
       are independently selected from the group consisting of aryl, substituted aryl, heteroaryl, substituted heteroaryl, heterocyclic, substituted heterocyclic, cycloalkyl, substituted cycloalkyl, cycloalkenyl and substituted cycloalkenyl. 
     
     
         2 - 20 . (canceled)