Bidens pilosa and polyacetylenic compounds for prevention and treatment of coccidiosis

Abstract

A composition for use in prevention, inhibition and/or treatment of coccidiosis in an animal is disclosed. The composition comprises an effective amount of Bidens pilosa , an active constituent thereof, or an active compound isolated therefrom.

What is claimed is: 
     
         1 . A composition comprising:
 (a) an animal feed; and   (b) a therapeutically effective amount of a  Bidens pilosa  extract or an active compound isolated from the  Bidens pilosa  extract to alleviate or treat the coccidiosis in the animal in need thereof, wherein the active compound isolated from the  Bidens pilosa  extract is a polyacetylenic compound of formula (I):   
       
         
           
           
               
               
           
         
         wherein
 R 1  is H or CH3; 
 R 2  is monosaccharide; 
 R 3  is H or COCH 2 COOH; 
 m=3 or 4; 
 n=0 or 1; 
 o=1 or 2; and 
 p=1 or 2. 
 
       
     
     
         2 . The composition of  claim 1 , wherein the composition is in a dosage form selected from the group consisting of oral, capsule, suppository and parenteral. 
     
     
         3 . The composition of  claim 1 , wherein the  Biden pilosa  extract is in a form of a powder. 
     
     
         4 . The composition of  claim 1 , wherein the animal feed is a chicken feed. 
     
     
         5 . The composition of  claim 1 , wherein the  Bidens pilosa  extract or the active compound isolated from the  Bidens pilosa  extract is mixed into the animal feed. 
     
     
         6 . The composition of  claim 1 , wherein the animal feed is selected from the group consisting of poultry feed, fish food, reptile food, bird feed, and non-human mammal food. 
     
     
         7 . The composition of  claim 1 , wherein the active compound is selected from the group consisting of: 
       
         
           
           
               
               
           
         
       
     
     
         8 . The composition of  claim 1 , wherein the composition comprises an active compound isolated from the  Bidens pilosa  extract. 
     
     
         9 . The composition of  claim 1 , wherein the composition comprises the animal feed and cytopiloyne at a ratio of 0.01 mg˜3 g of cytopiloyne per kilogram of the animal feed. 
     
     
         10 . The composition of  claim 1 , wherein the composition comprises the animal feed and no more than 15% (w/w) of  Bidens pilosa.    
     
     
         11 . The composition of  claim 1 , wherein the composition comprises the animal feed and no less than 0.0005% (w/w) of  Bidens pilosa.    
     
     
         12 . The composition of  claim 11 , wherein the composition comprises no more than 15% (w/w) of  Bidens pilosa.